Transcellular Cycles Underlying Neurotransmission
Synaptic transmission demands the operation of a highly specialized metabolic machinery involving the transfer of metabolites and neurotransmitters between neurons, astrocytes and microvessels. In the last years, important advances have occurred in our understanding of the mechanisms underlying cere...
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| Главный автор: | |
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| Формат: | Online |
| Язык: | английский |
| Опубликовано: |
Frontiers Media SA
2021
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| Предметы: | |
| Online-ссылка: | 19557 |
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Нет меток, Требуется 1-ая метка записи!
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| _version_ | 1869523000093573120 |
|---|---|
| author | Sebastian Cerdan |
| author_browse | Sebastian Cerdan |
| author_facet | Sebastian Cerdan |
| author_sort | Sebastian Cerdan |
| collection | Directory of Open Access Books |
| description | Synaptic transmission demands the operation of a highly specialized metabolic machinery involving the transfer of metabolites and neurotransmitters between neurons, astrocytes and microvessels. In the last years, important advances have occurred in our understanding of the mechanisms underlying cerebral activation, neuroglial coupling and the associated neurovascular response. Briefly, exacerbated oxygen consumption in stimulated neurons is thought to trigger glycolytic lactate and glucose transfer from astrocytes which, in turn, obtain these fuels from the microvasculature. Neurotransmitter release is made possible by a combination of transcellular cycles exchanging metabolites between these three compartments, returning eventually the synapsis to its pre-firing situation in the resting periods. In spite of the enormous progresses achieved in recent years, the drivers determining the predominant direction of the fluxes, their quantitative contribution and their energy requirements, have remained until today incompletely understood, more particularly under the circumstances prevailing in vivo. In many instances, progress derived from the implementation of novel methodological approaches including advanced neuroimaging and neurospectroscopy methods. As a consequence, literature in the field became vast, diverse and spread within journals of different specialities. The e-book "Transcellular cycles underlying neurotransmission" aims to summaryze in a single volume, recent progress achieved in hypothesis, methods and interpretations on the trafficking of metabolites between neurons and glial cells, and the associated mechanisms of neurovascular coupling. |
| format | Online |
| id | doab-20.500.12854ir-61171 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-611712024-04-05T12:36:29Z Transcellular Cycles Underlying Neurotransmission Sebastian Cerdan RC321-571 Q1-390 Neuroimaging functional MRI Neuroglial metabolic coupling glutamate-glutamine cycle Astrocytic Networks Astrocyte-neuron lactate shuttle 13C NMR Neurovascular coupling thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Synaptic transmission demands the operation of a highly specialized metabolic machinery involving the transfer of metabolites and neurotransmitters between neurons, astrocytes and microvessels. In the last years, important advances have occurred in our understanding of the mechanisms underlying cerebral activation, neuroglial coupling and the associated neurovascular response. Briefly, exacerbated oxygen consumption in stimulated neurons is thought to trigger glycolytic lactate and glucose transfer from astrocytes which, in turn, obtain these fuels from the microvasculature. Neurotransmitter release is made possible by a combination of transcellular cycles exchanging metabolites between these three compartments, returning eventually the synapsis to its pre-firing situation in the resting periods. In spite of the enormous progresses achieved in recent years, the drivers determining the predominant direction of the fluxes, their quantitative contribution and their energy requirements, have remained until today incompletely understood, more particularly under the circumstances prevailing in vivo. In many instances, progress derived from the implementation of novel methodological approaches including advanced neuroimaging and neurospectroscopy methods. As a consequence, literature in the field became vast, diverse and spread within journals of different specialities. The e-book "Transcellular cycles underlying neurotransmission" aims to summaryze in a single volume, recent progress achieved in hypothesis, methods and interpretations on the trafficking of metabolites between neurons and glial cells, and the associated mechanisms of neurovascular coupling. 2021-02-12T06:21:10Z 2021-02-12T06:21:10Z 2016-08-16 10:34:25 2015 book 19557 16648714 9782889196548 https://directory.doabooks.org/handle/20.500.12854/61171 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Transcellular_Cycles_underlying_Neurotransmission/701#nogo http://journal.frontiersin.org/researchtopic/120/transcellular-cycles-underlying-neurotransmission Frontiers Media SA 10.3389/978-2-88919-654-8 10.3389/978-2-88919-654-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889196548 105 open access |
| spellingShingle | RC321-571 Q1-390 Neuroimaging functional MRI Neuroglial metabolic coupling glutamate-glutamine cycle Astrocytic Networks Astrocyte-neuron lactate shuttle 13C NMR Neurovascular coupling thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Sebastian Cerdan Transcellular Cycles Underlying Neurotransmission |
| title | Transcellular Cycles Underlying Neurotransmission |
| title_full | Transcellular Cycles Underlying Neurotransmission |
| title_fullStr | Transcellular Cycles Underlying Neurotransmission |
| title_full_unstemmed | Transcellular Cycles Underlying Neurotransmission |
| title_short | Transcellular Cycles Underlying Neurotransmission |
| title_sort | transcellular cycles underlying neurotransmission |
| topic | RC321-571 Q1-390 Neuroimaging functional MRI Neuroglial metabolic coupling glutamate-glutamine cycle Astrocytic Networks Astrocyte-neuron lactate shuttle 13C NMR Neurovascular coupling thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Neuroimaging functional MRI Neuroglial metabolic coupling glutamate-glutamine cycle Astrocytic Networks Astrocyte-neuron lactate shuttle 13C NMR Neurovascular coupling thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 19557 |
| work_keys_str_mv | AT sebastiancerdan transcellularcyclesunderlyingneurotransmission |