The Transcriptional Regulation of Memory
The formation of various forms of memory involves a series of distinct cellular and molecular mechanisms, many of which are not fully understood. There are highly conserved pathways that are involved in learning, memory, and synaptic plasticity, which is the primary substrate for memory storage. The...
Sparad:
| Huvudupphov: | , |
|---|---|
| Materialtyp: | Online |
| Språk: | engelska |
| Utgiven: |
Frontiers Media SA
2021
|
| Ämnen: | |
| Länkar: | 18252 |
| Taggar: |
Inga taggar, Lägg till första taggen!
|
| _version_ | 1869526762449272832 |
|---|---|
| author | Benedict C. Albensi Jelena Djordjevic |
| author_browse | Benedict C. Albensi Jelena Djordjevic |
| author_facet | Benedict C. Albensi Jelena Djordjevic |
| author_sort | Benedict C. Albensi |
| collection | Directory of Open Access Books |
| description | The formation of various forms of memory involves a series of distinct cellular and molecular mechanisms, many of which are not fully understood. There are highly conserved pathways that are involved in learning, memory, and synaptic plasticity, which is the primary substrate for memory storage. The formation of short-term (across minutes) memory is mediated by local changes in synapses, while long-term (across hours to days) memory storage is associated with activation of transcription and synthesis of proteins that modify synaptic function. Transcription factors, which can either repress or activate transcription, play a vital role in driving protein synthesis underlying synaptic plasticity and memory, whereby protein synthesis provides the necessary building blocks to accommodate structural changes at the synapse that foster memory formation. Recent data implicate several families of transcription factors that appear critically important in the regulation of memory. In this Topic we will focus on the families of transcription factors thus far found to be critically involved in synaptic plasticity and memory formation. These include cAMP response element binding protein (CREB), Rel/nuclear factor B (Rel/NFB), CCAAT enhancer binding protein (C/EBP), and early growth response factor (Egr). In recent years, numerous studies have implicated epigenetic mechanisms, changes in gene activity and expression that occur without alteration in gene sequence, in the memory consolidation process. DNA methylation and chromatin remodeling are critically involved in learning and memory, supporting a role of epigenetic mechanisms. Here we provide more evidence of the importance of DNA methylation, histone posttranslational modifications and the role of histone acetylation and HDAC inhibitors in above mentioned processes. |
| format | Online |
| id | doab-20.500.12854ir-61177 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-611772024-04-05T17:31:23Z The Transcriptional Regulation of Memory Benedict C. Albensi Jelena Djordjevic RC321-571 Q1-390 Learning Memory Transcription Factors synaptic plasticity epigenetics thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences The formation of various forms of memory involves a series of distinct cellular and molecular mechanisms, many of which are not fully understood. There are highly conserved pathways that are involved in learning, memory, and synaptic plasticity, which is the primary substrate for memory storage. The formation of short-term (across minutes) memory is mediated by local changes in synapses, while long-term (across hours to days) memory storage is associated with activation of transcription and synthesis of proteins that modify synaptic function. Transcription factors, which can either repress or activate transcription, play a vital role in driving protein synthesis underlying synaptic plasticity and memory, whereby protein synthesis provides the necessary building blocks to accommodate structural changes at the synapse that foster memory formation. Recent data implicate several families of transcription factors that appear critically important in the regulation of memory. In this Topic we will focus on the families of transcription factors thus far found to be critically involved in synaptic plasticity and memory formation. These include cAMP response element binding protein (CREB), Rel/nuclear factor B (Rel/NFB), CCAAT enhancer binding protein (C/EBP), and early growth response factor (Egr). In recent years, numerous studies have implicated epigenetic mechanisms, changes in gene activity and expression that occur without alteration in gene sequence, in the memory consolidation process. DNA methylation and chromatin remodeling are critically involved in learning and memory, supporting a role of epigenetic mechanisms. Here we provide more evidence of the importance of DNA methylation, histone posttranslational modifications and the role of histone acetylation and HDAC inhibitors in above mentioned processes. 2021-02-12T06:21:27Z 2021-02-12T06:21:27Z 2016-01-19 14:05:46 2016 book 18252 16648714 9782889198658 https://directory.doabooks.org/handle/20.500.12854/61177 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/The_Transcriptional_Regulation_of_Memory/895 http://journal.frontiersin.org/researchtopic/3538/the-transcriptional-regulation-of-memory Frontiers Media SA 10.3389/978-2-88919-865-8 10.3389/978-2-88919-865-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889198658 116 open access |
| spellingShingle | RC321-571 Q1-390 Learning Memory Transcription Factors synaptic plasticity epigenetics thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Benedict C. Albensi Jelena Djordjevic The Transcriptional Regulation of Memory |
| title | The Transcriptional Regulation of Memory |
| title_full | The Transcriptional Regulation of Memory |
| title_fullStr | The Transcriptional Regulation of Memory |
| title_full_unstemmed | The Transcriptional Regulation of Memory |
| title_short | The Transcriptional Regulation of Memory |
| title_sort | transcriptional regulation of memory |
| topic | RC321-571 Q1-390 Learning Memory Transcription Factors synaptic plasticity epigenetics thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Learning Memory Transcription Factors synaptic plasticity epigenetics thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18252 |
| work_keys_str_mv | AT benedictcalbensi thetranscriptionalregulationofmemory AT jelenadjordjevic thetranscriptionalregulationofmemory AT benedictcalbensi transcriptionalregulationofmemory AT jelenadjordjevic transcriptionalregulationofmemory |