Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts
The year 2017 marks the 20th anniversary of the molecular cloning of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1). This seminal discovery has opened up a “hot” new field of basic research and launched drug discovery efforts into the large fa...
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| Үндсэн зохиолчид: | , |
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| Формат: | Online |
| Хэл сонгох: | англи |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Нөхцлүүд: | |
| Онлайн хандалт: | 27164 |
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Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!
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| _version_ | 1869515345677516800 |
|---|---|
| author | Susan M. Huang (Ed.) Arpad Szallasi (Ed.) |
| author_browse | Arpad Szallasi (Ed.) Susan M. Huang (Ed.) |
| author_facet | Susan M. Huang (Ed.) Arpad Szallasi (Ed.) |
| author_sort | Susan M. Huang (Ed.) |
| collection | Directory of Open Access Books |
| description | The year 2017 marks the 20th anniversary of the molecular cloning of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1). This seminal discovery has opened up a “hot” new field of basic research and launched drug discovery efforts into the large family (by the latest count, 28 mammalian members and 27 in humans) of TRP ion channels. Indeed, it took less than a decade for the first potent, small molecule TRPV1 antagonists to enter phase 1 clinical trials, closely followed by TRPA1 and TRPM8 antagonists. The literature on TRP channels is immense. TRPV1 alone is a keyword in over 5000 publications searchable in PubMed. Clearly, it is not possible to capture the entire literature in a single thematic issue. Consequently, the selection of articles presented in this book represents a sampling of the literature, and is admittedly subjective. We tried to survey the wide range of human diseases in which TRP channels have been implicated, ranging from chronic pain through asthma and diabetes to cancer, and highlight the channels that appear to hold the greatest promise for therapeutic targeting. With this book, we hope to convince readers that TRP channels constitute a formidable family of potential therapeutic targets that will likely continue to demand attention. |
| format | Online |
| id | doab-20.500.12854ir-61214 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-612142024-04-01T14:14:49Z Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts Susan M. Huang (Ed.) Arpad Szallasi (Ed.) RM1-950 resiniferatoxin pain TRPA1 TRPV3 TRPV1 TRP channels TRPM2 respiratory disorders permanent analgesia capsaicin TRPM7 cancer TRPM8 diabetes obesity thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology The year 2017 marks the 20th anniversary of the molecular cloning of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1). This seminal discovery has opened up a “hot” new field of basic research and launched drug discovery efforts into the large family (by the latest count, 28 mammalian members and 27 in humans) of TRP ion channels. Indeed, it took less than a decade for the first potent, small molecule TRPV1 antagonists to enter phase 1 clinical trials, closely followed by TRPA1 and TRPM8 antagonists. The literature on TRP channels is immense. TRPV1 alone is a keyword in over 5000 publications searchable in PubMed. Clearly, it is not possible to capture the entire literature in a single thematic issue. Consequently, the selection of articles presented in this book represents a sampling of the literature, and is admittedly subjective. We tried to survey the wide range of human diseases in which TRP channels have been implicated, ranging from chronic pain through asthma and diabetes to cancer, and highlight the channels that appear to hold the greatest promise for therapeutic targeting. With this book, we hope to convince readers that TRP channels constitute a formidable family of potential therapeutic targets that will likely continue to demand attention. 2021-02-12T06:24:18Z 2021-02-12T06:24:18Z 2018-06-22 11:29:17 2018 book 27164 9783038426394 9783038426387 https://directory.doabooks.org/handle/20.500.12854/61214 eng image/png Attribution-NonCommercial-NoDerivatives 4.0 International http://www.mdpi.com/books/pdfview/book/645 http://www.mdpi.com/books/pdfview/book/645 MDPI - Multidisciplinary Digital Publishing Institute 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038426394 9783038426387 VI, 250 open access |
| spellingShingle | RM1-950 resiniferatoxin pain TRPA1 TRPV3 TRPV1 TRP channels TRPM2 respiratory disorders permanent analgesia capsaicin TRPM7 cancer TRPM8 diabetes obesity thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Susan M. Huang (Ed.) Arpad Szallasi (Ed.) Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts |
| title | Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts |
| title_full | Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts |
| title_fullStr | Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts |
| title_full_unstemmed | Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts |
| title_short | Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts |
| title_sort | transient receptor potential trp channels in drug discovery old concepts new thoughts |
| topic | RM1-950 resiniferatoxin pain TRPA1 TRPV3 TRPV1 TRP channels TRPM2 respiratory disorders permanent analgesia capsaicin TRPM7 cancer TRPM8 diabetes obesity thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | RM1-950 resiniferatoxin pain TRPA1 TRPV3 TRPV1 TRP channels TRPM2 respiratory disorders permanent analgesia capsaicin TRPM7 cancer TRPM8 diabetes obesity thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | 27164 |
| work_keys_str_mv | AT susanmhuanged transientreceptorpotentialtrpchannelsindrugdiscoveryoldconceptsnewthoughts AT arpadszallasied transientreceptorpotentialtrpchannelsindrugdiscoveryoldconceptsnewthoughts |