Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics
Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adapta...
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| Format: | Online |
| Język: | angielski |
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Frontiers Media SA
2021
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| Dostęp online: | 22916 |
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| _version_ | 1869521639303020544 |
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| author | Christian R. Gomez |
| author_browse | Christian R. Gomez |
| author_facet | Christian R. Gomez |
| author_sort | Christian R. Gomez |
| collection | Directory of Open Access Books |
| description | Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adaptations of tumor cells leading to genetic instability, intratumor heterogeneity and malignant progression. On the success of our fight against cancer, the continued adaptability of tumors to their microenvironmental stresses, such as hypoxia, must be considered. Tumor cells are endowed with a very high plasticity and capacity to adapt. It is our challenge to find populations and conditions of the tumor microenvironment germane for target success. Interdisciplinary work will be the key for achievement of these goals. This e-book is a compendium of original reports and review articles contributed by world-class experts in the field of tumor hypoxia. This material will be useful to foster discussion and increase understanding of the involvement of hypoxia in tumorigenesis, biomarker development, and therapeutics.Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adaptations of tumor cells leading to genetic instability, intratumor heterogeneity and malignant progression. On the success of our fight against cancer, the continued adaptability of tumors to their microenvironmental stresses, such as hypoxia, must be considered. Tumor cells are endowed with a very high plasticity and capacity to adapt. It is our challenge to find populations and conditions of the tumor microenvironment germane for target success. Interdisciplinary work will be the key for achievement of these goals. This e-book is a compendium of original reports and review articles contributed by world-class experts in the field of tumor hypoxia. This material will be useful to foster discussion and increase understanding of the involvement of hypoxia in tumorigenesis, biomarker development, and therapeutics. |
| format | Online |
| id | doab-20.500.12854ir-61392 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-613922024-03-30T23:22:53Z Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics Christian R. Gomez R5-920 QH301-705.5 RC254-282 Q1-390 microenvironment Stem Cells hypoxia stress HIF tumor Leukemia biomarkers therapy pH thema EDItEUR::M Medicine and Nursing Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adaptations of tumor cells leading to genetic instability, intratumor heterogeneity and malignant progression. On the success of our fight against cancer, the continued adaptability of tumors to their microenvironmental stresses, such as hypoxia, must be considered. Tumor cells are endowed with a very high plasticity and capacity to adapt. It is our challenge to find populations and conditions of the tumor microenvironment germane for target success. Interdisciplinary work will be the key for achievement of these goals. This e-book is a compendium of original reports and review articles contributed by world-class experts in the field of tumor hypoxia. This material will be useful to foster discussion and increase understanding of the involvement of hypoxia in tumorigenesis, biomarker development, and therapeutics.Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adaptations of tumor cells leading to genetic instability, intratumor heterogeneity and malignant progression. On the success of our fight against cancer, the continued adaptability of tumors to their microenvironmental stresses, such as hypoxia, must be considered. Tumor cells are endowed with a very high plasticity and capacity to adapt. It is our challenge to find populations and conditions of the tumor microenvironment germane for target success. Interdisciplinary work will be the key for achievement of these goals. This e-book is a compendium of original reports and review articles contributed by world-class experts in the field of tumor hypoxia. This material will be useful to foster discussion and increase understanding of the involvement of hypoxia in tumorigenesis, biomarker development, and therapeutics. 2021-02-12T06:41:34Z 2021-02-12T06:41:34Z 2017-07-06 13:27:36 2017 book 22916 16648714 9782889450640 https://directory.doabooks.org/handle/20.500.12854/61392 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Tumor_Hypoxia_Impact_in_Tumorigenesis_Diagnosis_Prognosis_and_Therapeutics/1113 http://journal.frontiersin.org/researchtopic/3972/tumor-hypoxia-impact-in-tumorigenesis-diagnosis-prognosis-and-therapeutics Frontiers Media SA 10.3389/978-2-88945-064-0 10.3389/978-2-88945-064-0 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889450640 113 open access |
| spellingShingle | R5-920 QH301-705.5 RC254-282 Q1-390 microenvironment Stem Cells hypoxia stress HIF tumor Leukemia biomarkers therapy pH thema EDItEUR::M Medicine and Nursing Christian R. Gomez Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics |
| title | Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics |
| title_full | Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics |
| title_fullStr | Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics |
| title_full_unstemmed | Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics |
| title_short | Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics |
| title_sort | tumor hypoxia impact in tumorigenesis diagnosis prognosis and therapeutics |
| topic | R5-920 QH301-705.5 RC254-282 Q1-390 microenvironment Stem Cells hypoxia stress HIF tumor Leukemia biomarkers therapy pH thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 QH301-705.5 RC254-282 Q1-390 microenvironment Stem Cells hypoxia stress HIF tumor Leukemia biomarkers therapy pH thema EDItEUR::M Medicine and Nursing |
| url | 22916 |
| work_keys_str_mv | AT christianrgomez tumorhypoxiaimpactintumorigenesisdiagnosisprognosisandtherapeutics |