Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System
Proteolysis by the ubiquitin-proteasome pathway (UPP) in the nervous system has been extensively studied both in the context of normal physiological function as well as abnormal pathological conditions. Although ubiquitin was used as a marker of brain pathology, the normal functions of the UPP were...
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| Format: | Online |
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Frontiers Media SA
2021
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| Online Access: | 25594 |
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| author | Ashok N. Hegde Fred W. van Leeuwen |
| author_browse | Ashok N. Hegde Fred W. van Leeuwen |
| author_facet | Ashok N. Hegde Fred W. van Leeuwen |
| author_sort | Ashok N. Hegde |
| collection | Directory of Open Access Books |
| description | Proteolysis by the ubiquitin-proteasome pathway (UPP) in the nervous system has been extensively studied both in the context of normal physiological function as well as abnormal pathological conditions. Although ubiquitin was used as a marker of brain pathology, the normal functions of the UPP were not studied much in the nervous system until the 1990s. The early investigations focused on synaptic plasticity which was followed by studies on the roles of protein degradation in the development of the nervous system. Research on the role of abnormal roles of the UPP follows a parallel trajectory. Since the 2000s, the field has grown to encompass many subareas of research and several model systems. Despite the progress made, many unanswered questions still remain. For example, there are many unknowns about the precise spatial and temporal control of protein degradation in the normal nervous system. With respect to the roles of proteolysis in brain pathology a major challenge is to elucidate the connection between impaired protein degradation and disease progression. In addition, in-depth studies of the roles of ubiquitin-proteasome-mediated proteolysis in neurodegenerative diseases are promising in identifying therapeutic targets. This ebook contains original research papers and insightful reviews that cover several aspects of proteolysis by the UPP and its physiological as well as pathological functions in the nervous system. |
| format | Online |
| id | doab-20.500.12854ir-61458 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-614582024-04-05T12:35:22Z Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System Ashok N. Hegde Fred W. van Leeuwen RC321-571 Q1-390 proteasome memory neuroinflammation neurodegenerative synaptic plasticity aging deubiquitinating Huntington's disease Alzheimer's disease glutamate receptors thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Proteolysis by the ubiquitin-proteasome pathway (UPP) in the nervous system has been extensively studied both in the context of normal physiological function as well as abnormal pathological conditions. Although ubiquitin was used as a marker of brain pathology, the normal functions of the UPP were not studied much in the nervous system until the 1990s. The early investigations focused on synaptic plasticity which was followed by studies on the roles of protein degradation in the development of the nervous system. Research on the role of abnormal roles of the UPP follows a parallel trajectory. Since the 2000s, the field has grown to encompass many subareas of research and several model systems. Despite the progress made, many unanswered questions still remain. For example, there are many unknowns about the precise spatial and temporal control of protein degradation in the normal nervous system. With respect to the roles of proteolysis in brain pathology a major challenge is to elucidate the connection between impaired protein degradation and disease progression. In addition, in-depth studies of the roles of ubiquitin-proteasome-mediated proteolysis in neurodegenerative diseases are promising in identifying therapeutic targets. This ebook contains original research papers and insightful reviews that cover several aspects of proteolysis by the UPP and its physiological as well as pathological functions in the nervous system. 2021-02-12T06:49:13Z 2021-02-12T06:49:13Z 2018-02-27 16:16:44 2017 book 25594 16648714 9782889452859 https://directory.doabooks.org/handle/20.500.12854/61458 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Ubiquitin_and_the_Brain_Roles_of_Proteolysis_in_the_Normal_and_Abnormal_Nervous_System/1347 https://www.frontiersin.org/research-topics/1934/ubiquitin-and-the-brain-roles-of-proteolysis-in-the-normal-and-abnormal-nervous-system Frontiers Media SA 10.3389/978-2-88945-285-9 10.3389/978-2-88945-285-9 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889452859 241 open access |
| spellingShingle | RC321-571 Q1-390 proteasome memory neuroinflammation neurodegenerative synaptic plasticity aging deubiquitinating Huntington's disease Alzheimer's disease glutamate receptors thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Ashok N. Hegde Fred W. van Leeuwen Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System |
| title | Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System |
| title_full | Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System |
| title_fullStr | Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System |
| title_full_unstemmed | Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System |
| title_short | Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System |
| title_sort | ubiquitin and the brain roles of proteolysis in the normal and abnormal nervous system |
| topic | RC321-571 Q1-390 proteasome memory neuroinflammation neurodegenerative synaptic plasticity aging deubiquitinating Huntington's disease Alzheimer's disease glutamate receptors thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 proteasome memory neuroinflammation neurodegenerative synaptic plasticity aging deubiquitinating Huntington's disease Alzheimer's disease glutamate receptors thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 25594 |
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