Understanding Crohn's Disease: Immunity, Genes and Microbes
Crohn's disease (CD) is a chronic, relapsing, inflammatory bowel disease resulting in considerable morbidity and reduced quality of life. Although still under intense debate, CD seems to result from an enhanced and uncontrolled immune response to the gut microbiota. CD is thought to be multifactoria...
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| Format: | Online |
| Język: | angielski |
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Frontiers Media SA
2021
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| Dostęp online: | 24019 |
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| _version_ | 1869530510072479744 |
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| author | Fernando Magro Nair Campos Amelia Sarmento |
| author_browse | Amelia Sarmento Fernando Magro Nair Campos |
| author_facet | Fernando Magro Nair Campos Amelia Sarmento |
| author_sort | Fernando Magro |
| collection | Directory of Open Access Books |
| description | Crohn's disease (CD) is a chronic, relapsing, inflammatory bowel disease resulting in considerable morbidity and reduced quality of life. Although still under intense debate, CD seems to result from an enhanced and uncontrolled immune response to the gut microbiota. CD is thought to be multifactorial depending on genetic and environmental determinants. In recent years, nearly 100 single nucleotide polymorphisms (SNPs) were associated with increased risk of developing CD (some of the SNPs also associated with susceptibility to ulcerative colitis, another type of IBD). These SNPs are mostly located in genes involved in innate and adaptive immunity mechanisms, such as autophagy, expression of pattern-recognition receptors and citokine signaling. Epigenetics is also probably playing a role in CD susceptibility, as it is sensitive to environmental conditions and may mediate gene-environment interactions. Environmental factors possibly involved in CD development include diet, gut microbiota composition and infection with specific pathogens, of which the most consistently associated to CD are Mycobacterium avium subsp. paratuberculosis and adherent-invasive Escherichia coli. This Topic aimed at bringing together contributions covering different genetic, epigenetic, immunological and microbial processes involved in the development of CD, helping to drive forward the understanding of CD immunopahtology. |
| format | Online |
| id | doab-20.500.12854ir-61527 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-615272024-03-31T13:10:14Z Understanding Crohn's Disease: Immunity, Genes and Microbes Fernando Magro Nair Campos Amelia Sarmento R5-920 RC581-607 intestinal microbiota mucosal immune system Crohn's disease T cells gene polymorphisms epigenetics mutritional modulation thema EDItEUR::M Medicine and Nursing Crohn's disease (CD) is a chronic, relapsing, inflammatory bowel disease resulting in considerable morbidity and reduced quality of life. Although still under intense debate, CD seems to result from an enhanced and uncontrolled immune response to the gut microbiota. CD is thought to be multifactorial depending on genetic and environmental determinants. In recent years, nearly 100 single nucleotide polymorphisms (SNPs) were associated with increased risk of developing CD (some of the SNPs also associated with susceptibility to ulcerative colitis, another type of IBD). These SNPs are mostly located in genes involved in innate and adaptive immunity mechanisms, such as autophagy, expression of pattern-recognition receptors and citokine signaling. Epigenetics is also probably playing a role in CD susceptibility, as it is sensitive to environmental conditions and may mediate gene-environment interactions. Environmental factors possibly involved in CD development include diet, gut microbiota composition and infection with specific pathogens, of which the most consistently associated to CD are Mycobacterium avium subsp. paratuberculosis and adherent-invasive Escherichia coli. This Topic aimed at bringing together contributions covering different genetic, epigenetic, immunological and microbial processes involved in the development of CD, helping to drive forward the understanding of CD immunopahtology. 2021-02-12T06:53:56Z 2021-02-12T06:53:56Z 2017-10-13 14:57:01 2017 book 24019 16648714 9782889452149 https://directory.doabooks.org/handle/20.500.12854/61527 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Understanding_Crohn_s_Disease_Immunity_Genes_and_Microbes/1283 http://journal.frontiersin.org/researchtopic/2407/understanding-crohns-disease-immunity-genes-and-microbes Frontiers Media SA 10.3389/978-2-88945-214-9 10.3389/978-2-88945-214-9 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889452149 126 open access |
| spellingShingle | R5-920 RC581-607 intestinal microbiota mucosal immune system Crohn's disease T cells gene polymorphisms epigenetics mutritional modulation thema EDItEUR::M Medicine and Nursing Fernando Magro Nair Campos Amelia Sarmento Understanding Crohn's Disease: Immunity, Genes and Microbes |
| title | Understanding Crohn's Disease: Immunity, Genes and Microbes |
| title_full | Understanding Crohn's Disease: Immunity, Genes and Microbes |
| title_fullStr | Understanding Crohn's Disease: Immunity, Genes and Microbes |
| title_full_unstemmed | Understanding Crohn's Disease: Immunity, Genes and Microbes |
| title_short | Understanding Crohn's Disease: Immunity, Genes and Microbes |
| title_sort | understanding crohn s disease immunity genes and microbes |
| topic | R5-920 RC581-607 intestinal microbiota mucosal immune system Crohn's disease T cells gene polymorphisms epigenetics mutritional modulation thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 intestinal microbiota mucosal immune system Crohn's disease T cells gene polymorphisms epigenetics mutritional modulation thema EDItEUR::M Medicine and Nursing |
| url | 24019 |
| work_keys_str_mv | AT fernandomagro understandingcrohnsdiseaseimmunitygenesandmicrobes AT naircampos understandingcrohnsdiseaseimmunitygenesandmicrobes AT ameliasarmento understandingcrohnsdiseaseimmunitygenesandmicrobes |