The unfolded protein response in virus infections
Unfolded protein response (UPR) is a cellular adaptive response for restoring endoplasmic reticulum (ER) homeostasis in response to ER stress. Perturbation of the UPR and failure to restore ER homeostasis inevitably leads to diseases. It has now become evident that perturbation of the UPR is the cau...
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| Aineistotyyppi: | Online |
| Kieli: | englanti |
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Frontiers Media SA
2021
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| Linkit: | 17767 |
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| _version_ | 1869521496536252416 |
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| author | Shiu-Wan Chan |
| author_browse | Shiu-Wan Chan |
| author_facet | Shiu-Wan Chan |
| author_sort | Shiu-Wan Chan |
| collection | Directory of Open Access Books |
| description | Unfolded protein response (UPR) is a cellular adaptive response for restoring endoplasmic reticulum (ER) homeostasis in response to ER stress. Perturbation of the UPR and failure to restore ER homeostasis inevitably leads to diseases. It has now become evident that perturbation of the UPR is the cause of many important human diseases such as neurodegenerative diseases, cystic fibrosis, diabetes and cancer. It has recently emerged that virus infections can trigger the UPR but the relationship between virus infections and host UPR is intriguing. On one hand, UPR is harmful to the virus and virus has developed means to subvert the UPR. On the other hand, virus exploits the host UPR to assist in its own infection, gene expression, establishment of persistence, reactivation from latency and to evade the immune response. When this delicate balance of virus-host UPR interaction is broken down, it may cause diseases. This is particularly challenging for viruses that establish a chronic infection to maintain this balance. Each virus interacts with the host UPR in a different way to suit their life style and how the virus interacts with the host UPR can define the characteristic of a particular virus infection. Understanding how a particular virus interacts with the host UPR may pave the way to the design of a new class of anti-viral that targets this particular pathway to skew the response towards anti-virus. This knowledge can also be translated into the clinics to help re-design oncolytic virotherapy and gene therapy. In this research topic we aimed to compile a collection of focused review articles, original research articles, commentary, opinion, hypothesis and methods to highlight the current advances in this burgeoning area of research, in an attempt to provide an in-depth understanding of how viruses interact with the host UPR, which may be beneficial to the future combat of viral and human diseases. |
| format | Online |
| id | doab-20.500.12854ir-61603 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
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| spelling | doab-20.500.12854ir-616032024-04-05T17:31:02Z The unfolded protein response in virus infections Shiu-Wan Chan QR1-502 QK1-989 Q1-390 ERAD virus-host interaction innate immunity Gene Therapy Pathogenesis Endoplasmic Reticulum Stress Unfolded Protein Response Autophagy thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) Unfolded protein response (UPR) is a cellular adaptive response for restoring endoplasmic reticulum (ER) homeostasis in response to ER stress. Perturbation of the UPR and failure to restore ER homeostasis inevitably leads to diseases. It has now become evident that perturbation of the UPR is the cause of many important human diseases such as neurodegenerative diseases, cystic fibrosis, diabetes and cancer. It has recently emerged that virus infections can trigger the UPR but the relationship between virus infections and host UPR is intriguing. On one hand, UPR is harmful to the virus and virus has developed means to subvert the UPR. On the other hand, virus exploits the host UPR to assist in its own infection, gene expression, establishment of persistence, reactivation from latency and to evade the immune response. When this delicate balance of virus-host UPR interaction is broken down, it may cause diseases. This is particularly challenging for viruses that establish a chronic infection to maintain this balance. Each virus interacts with the host UPR in a different way to suit their life style and how the virus interacts with the host UPR can define the characteristic of a particular virus infection. Understanding how a particular virus interacts with the host UPR may pave the way to the design of a new class of anti-viral that targets this particular pathway to skew the response towards anti-virus. This knowledge can also be translated into the clinics to help re-design oncolytic virotherapy and gene therapy. In this research topic we aimed to compile a collection of focused review articles, original research articles, commentary, opinion, hypothesis and methods to highlight the current advances in this burgeoning area of research, in an attempt to provide an in-depth understanding of how viruses interact with the host UPR, which may be beneficial to the future combat of viral and human diseases. 2021-02-12T07:00:25Z 2021-02-12T07:00:25Z 2015-12-03 13:02:24 2015 book 17767 16648714 9782889193974 https://directory.doabooks.org/handle/20.500.12854/61603 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/The_unfolded_protein_response_in_virus_infections_/460 http://journal.frontiersin.org/researchtopic/2059/the-unfolded-protein-response-in-virus-infections Frontiers Media SA 10.3389/978-2-88919-397-4 10.3389/978-2-88919-397-4 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889193974 129 open access |
| spellingShingle | QR1-502 QK1-989 Q1-390 ERAD virus-host interaction innate immunity Gene Therapy Pathogenesis Endoplasmic Reticulum Stress Unfolded Protein Response Autophagy thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) Shiu-Wan Chan The unfolded protein response in virus infections |
| title | The unfolded protein response in virus infections |
| title_full | The unfolded protein response in virus infections |
| title_fullStr | The unfolded protein response in virus infections |
| title_full_unstemmed | The unfolded protein response in virus infections |
| title_short | The unfolded protein response in virus infections |
| title_sort | unfolded protein response in virus infections |
| topic | QR1-502 QK1-989 Q1-390 ERAD virus-host interaction innate immunity Gene Therapy Pathogenesis Endoplasmic Reticulum Stress Unfolded Protein Response Autophagy thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| topic_facet | QR1-502 QK1-989 Q1-390 ERAD virus-host interaction innate immunity Gene Therapy Pathogenesis Endoplasmic Reticulum Stress Unfolded Protein Response Autophagy thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| url | 17767 |
| work_keys_str_mv | AT shiuwanchan theunfoldedproteinresponseinvirusinfections AT shiuwanchan unfoldedproteinresponseinvirusinfections |