Using Stress-Based Animal Models to Understand the Mechanisms Underlying Psychiatric and Somatic Disorders
Chronic or repeated stress, particularly psychosocial stress, is an acknowledged risk factor for numerous affective and somatic disorders in modern societies. Thus, there is substantial evidence showing that chronic stress can increase the likelihood of major depressive disorder and anxiety disorder...
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| Glavni autori: | , |
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| Format: | Online |
| Jezik: | engleski |
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Frontiers Media SA
2021
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| Online pristup: | 22935 |
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| _version_ | 1869518519176003584 |
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| author | Stefan O. Reber David A. Slattery |
| author_browse | David A. Slattery Stefan O. Reber |
| author_facet | Stefan O. Reber David A. Slattery |
| author_sort | Stefan O. Reber |
| collection | Directory of Open Access Books |
| description | Chronic or repeated stress, particularly psychosocial stress, is an acknowledged risk factor for numerous affective and somatic disorders in modern societies. Thus, there is substantial evidence showing that chronic stress can increase the likelihood of major depressive disorder and anxiety disorders, as well as cardiovascular diseases, irritable bowel syndrome and pain syndromes, to name but a few, in vulnerable individuals. Although a number of pharmacological agents are available to treat such stress-related disorders, many patients do not respond to them, and those who do often report a number of side effects. Therefore, a major emphasis in modern basic research is to uncover the underlying aetiology of these disorders, and to develop novel efficacious treatment strategies. This has led to a resurgence in developing, and using, appropriate animal models to study a wide variety of stress-related disorders. Thus, the aim of this research topic “Using stress-based animal models to understand the mechanisms underlying psychiatric and somatic disorders” was to bring together novel research articles and comprehensive review articles from prominent stress researchers. In addition to describing the insights such models have provided relating to the aetiology of psychiatric and somatic disorders, these articles also encompass mechanisms that are believed to underlie stress resilience and stress-protection. Finally, given the current prominence on the role of the brain-gut axis in health and disease, the research topic covers the emerging evidence showing how the gut, particularly the microbiota, influences affective behaviour and physiology. |
| format | Online |
| id | doab-20.500.12854ir-61799 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-617992024-03-30T23:22:19Z Using Stress-Based Animal Models to Understand the Mechanisms Underlying Psychiatric and Somatic Disorders Stefan O. Reber David A. Slattery R5-920 RC435-571 stress Glucocorticoids Irritable Bowel Syndrome behaviour microbiome Animal Models Prefrontal Cortex thema EDItEUR::M Medicine and Nursing Chronic or repeated stress, particularly psychosocial stress, is an acknowledged risk factor for numerous affective and somatic disorders in modern societies. Thus, there is substantial evidence showing that chronic stress can increase the likelihood of major depressive disorder and anxiety disorders, as well as cardiovascular diseases, irritable bowel syndrome and pain syndromes, to name but a few, in vulnerable individuals. Although a number of pharmacological agents are available to treat such stress-related disorders, many patients do not respond to them, and those who do often report a number of side effects. Therefore, a major emphasis in modern basic research is to uncover the underlying aetiology of these disorders, and to develop novel efficacious treatment strategies. This has led to a resurgence in developing, and using, appropriate animal models to study a wide variety of stress-related disorders. Thus, the aim of this research topic “Using stress-based animal models to understand the mechanisms underlying psychiatric and somatic disorders” was to bring together novel research articles and comprehensive review articles from prominent stress researchers. In addition to describing the insights such models have provided relating to the aetiology of psychiatric and somatic disorders, these articles also encompass mechanisms that are believed to underlie stress resilience and stress-protection. Finally, given the current prominence on the role of the brain-gut axis in health and disease, the research topic covers the emerging evidence showing how the gut, particularly the microbiota, influences affective behaviour and physiology. 2021-02-12T07:16:31Z 2021-02-12T07:16:31Z 2017-07-06 13:27:36 2017 book 22935 16648714 9782889450848 https://directory.doabooks.org/handle/20.500.12854/61799 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Using_Stress-Based_Animal_Models_to_Understand_the_Mechanisms_Underlying_Psychiatric_and_Somatic_Di/1094#nogo http://journal.frontiersin.org/researchtopic/2534/using-stress-based-animal-models-to-understand-the-mechanisms-underlying-psychiatric-and-somatic-dis Frontiers Media SA 10.3389/978-2-88945-084-8 10.3389/978-2-88945-084-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889450848 129 open access |
| spellingShingle | R5-920 RC435-571 stress Glucocorticoids Irritable Bowel Syndrome behaviour microbiome Animal Models Prefrontal Cortex thema EDItEUR::M Medicine and Nursing Stefan O. Reber David A. Slattery Using Stress-Based Animal Models to Understand the Mechanisms Underlying Psychiatric and Somatic Disorders |
| title | Using Stress-Based Animal Models to Understand the Mechanisms Underlying Psychiatric and Somatic Disorders |
| title_full | Using Stress-Based Animal Models to Understand the Mechanisms Underlying Psychiatric and Somatic Disorders |
| title_fullStr | Using Stress-Based Animal Models to Understand the Mechanisms Underlying Psychiatric and Somatic Disorders |
| title_full_unstemmed | Using Stress-Based Animal Models to Understand the Mechanisms Underlying Psychiatric and Somatic Disorders |
| title_short | Using Stress-Based Animal Models to Understand the Mechanisms Underlying Psychiatric and Somatic Disorders |
| title_sort | using stress based animal models to understand the mechanisms underlying psychiatric and somatic disorders |
| topic | R5-920 RC435-571 stress Glucocorticoids Irritable Bowel Syndrome behaviour microbiome Animal Models Prefrontal Cortex thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC435-571 stress Glucocorticoids Irritable Bowel Syndrome behaviour microbiome Animal Models Prefrontal Cortex thema EDItEUR::M Medicine and Nursing |
| url | 22935 |
| work_keys_str_mv | AT stefanoreber usingstressbasedanimalmodelstounderstandthemechanismsunderlyingpsychiatricandsomaticdisorders AT davidaslattery usingstressbasedanimalmodelstounderstandthemechanismsunderlyingpsychiatricandsomaticdisorders |