The Vascular Niche in Tissue Repair: A Therapeutic Target for Regeneration
Tissues and organs have, although sometimes limited, the capacity for endogenous repair, which is aimed to re-establish integrity and homeostasis. Tissue repair involves pro- and anti-inflammatory processes, new tissue formation and remodelling. Depending on the local microenvironment, tissue repair...
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| Materiálatiipa: | Online |
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Frontiers Media SA
2021
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| Liŋkkat: | 29642 |
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| _version_ | 1869526535634944000 |
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| author | Francisco J. Rivera Ludwig Aigner |
| author_browse | Francisco J. Rivera Ludwig Aigner |
| author_facet | Francisco J. Rivera Ludwig Aigner |
| author_sort | Francisco J. Rivera |
| collection | Directory of Open Access Books |
| description | Tissues and organs have, although sometimes limited, the capacity for endogenous repair, which is aimed to re-establish integrity and homeostasis. Tissue repair involves pro- and anti-inflammatory processes, new tissue formation and remodelling. Depending on the local microenvironment, tissue repair results either in scar tissue formation or in regeneration. The latter aims to recapitulate the original tissue structure and architecture with the proper functionality. Although some organisms (such as planarians) have a high regenerative capacity throughout the body, in humans this property is more restricted to a few organs and tissues. Regeneration in the adult is possible in particular through the existence of tissue-resident pools of stem/progenitor cells. In response to tissue damage, these cells are activated, they proliferate and migrate, and differentiate into mature cells. Angiogenesis and neovascularization play a crucial role in tissue repair. Besides providing with oxygen and nutrients, angiogenesis generates a vascular niche (VN) consisting of different blood-derived elements and endothelial cells surrounded by basement membrane as well as perivascular cells. The newly generated VN communicates with the local stem/progenitor cells and contributes to tissue repair. For example, platelets, macrophages, neutrophils, perivascular cells and other VN components actively participate in the repair of skin, bone, muscle, tendon, brain, spinal cord, etc. Despite these observations, the exact role of the VN in tissue repair and the underlying mechanisms are still unclear and are awaiting further evidence that, indeed, will be required for the development of regenerative therapies for the treatment of traumatic injuries as well as degenerative diseases. |
| format | Online |
| id | doab-20.500.12854ir-61874 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-618742024-04-05T17:31:19Z The Vascular Niche in Tissue Repair: A Therapeutic Target for Regeneration Francisco J. Rivera Ludwig Aigner RC321-571 QP1-981 QH301-705.5 Q1-390 Angiogenesis Platelets and Platelets Lysate Blood Vessels and Endothelial Cells Granulocyte Colony Stimulating Factor (G-CSF) Pericytes Stem and Progenitor Cells Vascular Niche Tissue Repair and Regeneration thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Tissues and organs have, although sometimes limited, the capacity for endogenous repair, which is aimed to re-establish integrity and homeostasis. Tissue repair involves pro- and anti-inflammatory processes, new tissue formation and remodelling. Depending on the local microenvironment, tissue repair results either in scar tissue formation or in regeneration. The latter aims to recapitulate the original tissue structure and architecture with the proper functionality. Although some organisms (such as planarians) have a high regenerative capacity throughout the body, in humans this property is more restricted to a few organs and tissues. Regeneration in the adult is possible in particular through the existence of tissue-resident pools of stem/progenitor cells. In response to tissue damage, these cells are activated, they proliferate and migrate, and differentiate into mature cells. Angiogenesis and neovascularization play a crucial role in tissue repair. Besides providing with oxygen and nutrients, angiogenesis generates a vascular niche (VN) consisting of different blood-derived elements and endothelial cells surrounded by basement membrane as well as perivascular cells. The newly generated VN communicates with the local stem/progenitor cells and contributes to tissue repair. For example, platelets, macrophages, neutrophils, perivascular cells and other VN components actively participate in the repair of skin, bone, muscle, tendon, brain, spinal cord, etc. Despite these observations, the exact role of the VN in tissue repair and the underlying mechanisms are still unclear and are awaiting further evidence that, indeed, will be required for the development of regenerative therapies for the treatment of traumatic injuries as well as degenerative diseases. 2021-02-12T07:24:08Z 2021-02-12T07:24:08Z 2018-11-16 17:17:57 2018 book 29642 16648714 9782889454105 https://directory.doabooks.org/handle/20.500.12854/61874 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/3255/the-vascular-niche-in-tissue-repair-a-therapeutic-target-for-regeneration Frontiers Media SA 10.3389/978-2-88945-410-5 10.3389/978-2-88945-410-5 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889454105 174 open access |
| spellingShingle | RC321-571 QP1-981 QH301-705.5 Q1-390 Angiogenesis Platelets and Platelets Lysate Blood Vessels and Endothelial Cells Granulocyte Colony Stimulating Factor (G-CSF) Pericytes Stem and Progenitor Cells Vascular Niche Tissue Repair and Regeneration thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Francisco J. Rivera Ludwig Aigner The Vascular Niche in Tissue Repair: A Therapeutic Target for Regeneration |
| title | The Vascular Niche in Tissue Repair: A Therapeutic Target for Regeneration |
| title_full | The Vascular Niche in Tissue Repair: A Therapeutic Target for Regeneration |
| title_fullStr | The Vascular Niche in Tissue Repair: A Therapeutic Target for Regeneration |
| title_full_unstemmed | The Vascular Niche in Tissue Repair: A Therapeutic Target for Regeneration |
| title_short | The Vascular Niche in Tissue Repair: A Therapeutic Target for Regeneration |
| title_sort | vascular niche in tissue repair a therapeutic target for regeneration |
| topic | RC321-571 QP1-981 QH301-705.5 Q1-390 Angiogenesis Platelets and Platelets Lysate Blood Vessels and Endothelial Cells Granulocyte Colony Stimulating Factor (G-CSF) Pericytes Stem and Progenitor Cells Vascular Niche Tissue Repair and Regeneration thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 QP1-981 QH301-705.5 Q1-390 Angiogenesis Platelets and Platelets Lysate Blood Vessels and Endothelial Cells Granulocyte Colony Stimulating Factor (G-CSF) Pericytes Stem and Progenitor Cells Vascular Niche Tissue Repair and Regeneration thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 29642 |
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