Viral Interactions with the Nucleus
Viruses cause numerous medically important diseases, affecting developing, developed, rich and poor alike. The diseases vary in severity, including chickenpox, smallpox, influenza, shingles, herpes, rabies, polio, Ebola, hanta fever, AIDS and the common cold, amongst others. Regardless of the type o...
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| Formato: | Online |
| Idioma: | inglês |
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Frontiers Media SA
2021
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| Acesso em linha: | 25561 |
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| _version_ | 1869530903184670720 |
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| author | Erin Joanne Walker Reena Ghildyal |
| author_browse | Erin Joanne Walker Reena Ghildyal |
| author_facet | Erin Joanne Walker Reena Ghildyal |
| author_sort | Erin Joanne Walker |
| collection | Directory of Open Access Books |
| description | Viruses cause numerous medically important diseases, affecting developing, developed, rich and poor alike. The diseases vary in severity, including chickenpox, smallpox, influenza, shingles, herpes, rabies, polio, Ebola, hanta fever, AIDS and the common cold, amongst others. Regardless of the type of tissue or organ affected, all viruses follow the same basic steps to infect host cells. Once in contact with host cells viruses release their genetic material into the cell followed by genome replication, production of viral proteins, assembly of the virus particle and egress from the infected cell. Viruses disrupt normal host cell processes in order to facilitate their own replication/assembly by re-directing cellular machinery for viral transcription, translation, assembly, release and by inhibiting antiviral responses. Regulated nuclear transport of macromolecules through the nuclear pore complex, the only means of transport across the nuclear membrane, is essential for normal cell function and an effective antiviral response. Many viruses disrupt or exploit the nucleocytoplasmic trafficking pathways in host cells. Cytoplasmic viruses exploit the host cell nucleocytoplasmic trafficking machinery to access nuclear functions and/or disrupt nuclear transport, while several DNA viruses use the trafficking pathways to enable export of their components into the cytoplasm; yet others complete their assembly within the nucleus and use nuclear export pathways to access the cytoplasm. Indeed, the many and varied interactions of viruses and viral proteins with nucleocytoplasmic trafficking components have been invaluable in pathway discovery. Importantly, mounting evidence suggests that these interactions play essential roles in virus replication/assembly and hence may be key to understanding pathophysiology of viral diseases. This Frontiers Research Topic is dedicated to the importance of nucleocytoplasmic trafficking to viral pathogenesis. |
| format | Online |
| id | doab-20.500.12854ir-62228 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-622282024-04-05T17:31:06Z Viral Interactions with the Nucleus Erin Joanne Walker Reena Ghildyal QR1-502 Q1-390 viral nuclear interactions nuclear transport DNA Viruses nuclear pore complex RNA Viruses thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) Viruses cause numerous medically important diseases, affecting developing, developed, rich and poor alike. The diseases vary in severity, including chickenpox, smallpox, influenza, shingles, herpes, rabies, polio, Ebola, hanta fever, AIDS and the common cold, amongst others. Regardless of the type of tissue or organ affected, all viruses follow the same basic steps to infect host cells. Once in contact with host cells viruses release their genetic material into the cell followed by genome replication, production of viral proteins, assembly of the virus particle and egress from the infected cell. Viruses disrupt normal host cell processes in order to facilitate their own replication/assembly by re-directing cellular machinery for viral transcription, translation, assembly, release and by inhibiting antiviral responses. Regulated nuclear transport of macromolecules through the nuclear pore complex, the only means of transport across the nuclear membrane, is essential for normal cell function and an effective antiviral response. Many viruses disrupt or exploit the nucleocytoplasmic trafficking pathways in host cells. Cytoplasmic viruses exploit the host cell nucleocytoplasmic trafficking machinery to access nuclear functions and/or disrupt nuclear transport, while several DNA viruses use the trafficking pathways to enable export of their components into the cytoplasm; yet others complete their assembly within the nucleus and use nuclear export pathways to access the cytoplasm. Indeed, the many and varied interactions of viruses and viral proteins with nucleocytoplasmic trafficking components have been invaluable in pathway discovery. Importantly, mounting evidence suggests that these interactions play essential roles in virus replication/assembly and hence may be key to understanding pathophysiology of viral diseases. This Frontiers Research Topic is dedicated to the importance of nucleocytoplasmic trafficking to viral pathogenesis. 2021-02-12T07:52:10Z 2021-02-12T07:52:10Z 2018-02-27 16:16:44 2017 book 25561 16648714 9782889452477 https://directory.doabooks.org/handle/20.500.12854/62228 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Viral_Interactions_with_the_Nucleus/1292 http://journal.frontiersin.org/researchtopic/2894/viral-interactions-with-the-nucleus Frontiers Media SA 10.3389/978-2-88945-247-7 10.3389/978-2-88945-247-7 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889452477 124 open access |
| spellingShingle | QR1-502 Q1-390 viral nuclear interactions nuclear transport DNA Viruses nuclear pore complex RNA Viruses thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) Erin Joanne Walker Reena Ghildyal Viral Interactions with the Nucleus |
| title | Viral Interactions with the Nucleus |
| title_full | Viral Interactions with the Nucleus |
| title_fullStr | Viral Interactions with the Nucleus |
| title_full_unstemmed | Viral Interactions with the Nucleus |
| title_short | Viral Interactions with the Nucleus |
| title_sort | viral interactions with the nucleus |
| topic | QR1-502 Q1-390 viral nuclear interactions nuclear transport DNA Viruses nuclear pore complex RNA Viruses thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| topic_facet | QR1-502 Q1-390 viral nuclear interactions nuclear transport DNA Viruses nuclear pore complex RNA Viruses thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| url | 25561 |
| work_keys_str_mv | AT erinjoannewalker viralinteractionswiththenucleus AT reenaghildyal viralinteractionswiththenucleus |