Viral Replication Complexes: Structures, Functions, Applications and Inhibitors
Viruses are obligate intracellular parasites that need to co-opt a living cell’s machinery for replication. At the heart of the viral replication machinery are the nucleic acid polymerases, which are responsible for efficiently copying the viral genome. This process must often be coordinated with ot...
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| Format: | Online |
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| Idioma: | anglès |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Matèries: | |
| Accés en línia: | 19283 |
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| _version_ | 1869527739616198656 |
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| collection | Directory of Open Access Books |
| description | Viruses are obligate intracellular parasites that need to co-opt a living cell’s machinery for replication. At the heart of the viral replication machinery are the nucleic acid polymerases, which are responsible for efficiently copying the viral genome. This process must often be coordinated with other viral processes including protein translation and viral packaging. The nucleic acid polymerases may also be responsible for generating genetic diversity that is important for escape from the host’s defenses. The polymerases and other components of the replication machinery may serve as potential anti-viral targets. In this Special Issue, we seek to highlight recent advances into uncovering the structure and function of viral replication complexes. We are especially seeking to highlight the wide-range of methodologies used to gain structural insight into viral replication. Topics of interest include molecular mechanisms of nucleic acid polymerases, nucleic acid recognition and translocation, fidelity and error correction, interactions with lipid membranes, and coordination/regulation of transcription, translation and replication processes. |
| format | Online |
| id | doab-20.500.12854ir-62230 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-622302022-01-31T19:24:19Z Viral Replication Complexes: Structures, Functions, Applications and Inhibitors replication polymerase translation assembly quasi-species structural biology fidelity nucleic acid virus Viruses are obligate intracellular parasites that need to co-opt a living cell’s machinery for replication. At the heart of the viral replication machinery are the nucleic acid polymerases, which are responsible for efficiently copying the viral genome. This process must often be coordinated with other viral processes including protein translation and viral packaging. The nucleic acid polymerases may also be responsible for generating genetic diversity that is important for escape from the host’s defenses. The polymerases and other components of the replication machinery may serve as potential anti-viral targets. In this Special Issue, we seek to highlight recent advances into uncovering the structure and function of viral replication complexes. We are especially seeking to highlight the wide-range of methodologies used to gain structural insight into viral replication. Topics of interest include molecular mechanisms of nucleic acid polymerases, nucleic acid recognition and translocation, fidelity and error correction, interactions with lipid membranes, and coordination/regulation of transcription, translation and replication processes. 2021-02-12T07:52:20Z 2021-02-12T07:52:20Z 2016-07-14 07:43:51 2016 book 19283 9783038421689 9783038421672 https://directory.doabooks.org/handle/20.500.12854/62230 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International http://amzn.to/2aeUBmy http://www.mdpi.com/books/pdfview/book/211 MDPI - Multidisciplinary Digital Publishing Institute 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038421689 9783038421672 XVI, 428 open access |
| spellingShingle | replication polymerase translation assembly quasi-species structural biology fidelity nucleic acid virus Viral Replication Complexes: Structures, Functions, Applications and Inhibitors |
| title | Viral Replication Complexes: Structures, Functions, Applications and Inhibitors |
| title_full | Viral Replication Complexes: Structures, Functions, Applications and Inhibitors |
| title_fullStr | Viral Replication Complexes: Structures, Functions, Applications and Inhibitors |
| title_full_unstemmed | Viral Replication Complexes: Structures, Functions, Applications and Inhibitors |
| title_short | Viral Replication Complexes: Structures, Functions, Applications and Inhibitors |
| title_sort | viral replication complexes structures functions applications and inhibitors |
| topic | replication polymerase translation assembly quasi-species structural biology fidelity nucleic acid virus |
| topic_facet | replication polymerase translation assembly quasi-species structural biology fidelity nucleic acid virus |
| url | 19283 |