When Chemistry Meets Biology - Generating Innovative Concepts, Methods and Tools for Scientific Discovery in the Plant Sciences
Biologically active small molecules have increasingly been applied in plant biology to dissect and understand biological systems. This is evident from the frequent use of potent and selective inhibitors of enzymes or other biological processes such as transcription, translation, or protein degradati...
সংরক্ষণ করুন:
| প্রধান লেখক: | , |
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| বিন্যাস: | Online |
| ভাষা: | ইংরেজি |
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Frontiers Media SA
2021
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | 18315 |
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কোনো ট্যাগ নেই, প্রথমজন হিসাবে ট্যাগ করুন!
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| _version_ | 1869528203854348288 |
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| author | Erich Kombrink Markus Kaiser |
| author_browse | Erich Kombrink Markus Kaiser |
| author_facet | Erich Kombrink Markus Kaiser |
| author_sort | Erich Kombrink |
| collection | Directory of Open Access Books |
| description | Biologically active small molecules have increasingly been applied in plant biology to dissect and understand biological systems. This is evident from the frequent use of potent and selective inhibitors of enzymes or other biological processes such as transcription, translation, or protein degradation. In contrast to animal systems, which are nurtured from drug research, the systematic development of novel bioactive small molecules as research tools for plant systems is a largely underexplored research area. This is surprising since bioactive small molecules bear great potential for generating new, powerful tools for dissecting diverse biological processes. In particular, when small molecules are integrated into genetic strategies (thereby defining “chemical genetics”), they may help to circumvent inherent problems of classical (forward) genetics. There are now clear examples of important, fundamental discoveries originating from plant chemical genetics that demonstrate the power, but not yet fully exploited potential, of this experimental approach. These include the unraveling of molecular mechanisms and critical steps in hormone signaling, activation of defense reactions and dynamic intracellular processes. The intention of this Research Topic of Frontiers in Plant Physiology is to summarize the current status of research at the interface between chemistry and biology and to identify future research challenges. The research topic covers diverse aspects of plant chemical biology, including the identification of bioactive small molecules through screening processes from chemical libraries and natural sources, which rely on robust and quantitative high-throughput bioassays, the critical evaluation and characterization of the compound’s activity (selectivity) and, ultimately, the identification of its protein target(s) and mode-of-action, which is yet the biggest challenge of all. Such well-characterized, selective chemicals are attractive tools for basic research, allowing the functional dissection of plant signaling processes, or for applied purposes, if designed for protection of crop plants from disease. New methods and data mining tools for assessing the bioactivity profile of compounds, exploring the chemical space for structure–function relationships, and comprehensive chemical fingerprinting (metabolomics) are also important strategies in plant chemical biology. In addition, there is a continuing need for diverse target-specific bioprobes that help profiling enzymatic activities or selectively label protein complexes or cellular compartments. To achieve these goals and to add suitable probes and methods to the experimental toolbox, plant biologists need to closely cooperate with synthetic chemists. The development of such tailored chemicals that beyond application in basic research can modify traits of crop plants or target specific classes of weeds or pests by collaboration of applied and academic research groups may provide a bright future for plant chemical biology. The current Research Topic covers the breadth of the field by presenting original research articles, methods papers, reviews, perspectives and opinions. |
| format | Online |
| id | doab-20.500.12854ir-62652 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-626522024-04-05T17:31:19Z When Chemistry Meets Biology - Generating Innovative Concepts, Methods and Tools for Scientific Discovery in the Plant Sciences Erich Kombrink Markus Kaiser QK1-989 Q1-390 Plant-pathogen interaction High-Throughput Screening agricultural biotechnology plant growth regulator Chemical Genetics bioactive small molecule Target identification Chemical Biology Plant immune response phytohormone thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences Biologically active small molecules have increasingly been applied in plant biology to dissect and understand biological systems. This is evident from the frequent use of potent and selective inhibitors of enzymes or other biological processes such as transcription, translation, or protein degradation. In contrast to animal systems, which are nurtured from drug research, the systematic development of novel bioactive small molecules as research tools for plant systems is a largely underexplored research area. This is surprising since bioactive small molecules bear great potential for generating new, powerful tools for dissecting diverse biological processes. In particular, when small molecules are integrated into genetic strategies (thereby defining “chemical genetics”), they may help to circumvent inherent problems of classical (forward) genetics. There are now clear examples of important, fundamental discoveries originating from plant chemical genetics that demonstrate the power, but not yet fully exploited potential, of this experimental approach. These include the unraveling of molecular mechanisms and critical steps in hormone signaling, activation of defense reactions and dynamic intracellular processes. The intention of this Research Topic of Frontiers in Plant Physiology is to summarize the current status of research at the interface between chemistry and biology and to identify future research challenges. The research topic covers diverse aspects of plant chemical biology, including the identification of bioactive small molecules through screening processes from chemical libraries and natural sources, which rely on robust and quantitative high-throughput bioassays, the critical evaluation and characterization of the compound’s activity (selectivity) and, ultimately, the identification of its protein target(s) and mode-of-action, which is yet the biggest challenge of all. Such well-characterized, selective chemicals are attractive tools for basic research, allowing the functional dissection of plant signaling processes, or for applied purposes, if designed for protection of crop plants from disease. New methods and data mining tools for assessing the bioactivity profile of compounds, exploring the chemical space for structure–function relationships, and comprehensive chemical fingerprinting (metabolomics) are also important strategies in plant chemical biology. In addition, there is a continuing need for diverse target-specific bioprobes that help profiling enzymatic activities or selectively label protein complexes or cellular compartments. To achieve these goals and to add suitable probes and methods to the experimental toolbox, plant biologists need to closely cooperate with synthetic chemists. The development of such tailored chemicals that beyond application in basic research can modify traits of crop plants or target specific classes of weeds or pests by collaboration of applied and academic research groups may provide a bright future for plant chemical biology. The current Research Topic covers the breadth of the field by presenting original research articles, methods papers, reviews, perspectives and opinions. 2021-02-12T08:32:00Z 2021-02-12T08:32:00Z 2016-01-19 14:05:46 2016 book 18315 16648714 9782889199280 https://directory.doabooks.org/handle/20.500.12854/62652 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/When_Chemistry_meets_Biology__Generating_Innovative_Concepts_Methods_and_Tools_for_Scientific_Disc/962#nogo http://journal.frontiersin.org/researchtopic/2002/when-chemistry-meets-biology---generating-innovative-concepts-methods-and-tools-for-scientific-disco Frontiers Media SA 10.3389/978-2-88919-928-0 10.3389/978-2-88919-928-0 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889199280 146 open access |
| spellingShingle | QK1-989 Q1-390 Plant-pathogen interaction High-Throughput Screening agricultural biotechnology plant growth regulator Chemical Genetics bioactive small molecule Target identification Chemical Biology Plant immune response phytohormone thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences Erich Kombrink Markus Kaiser When Chemistry Meets Biology - Generating Innovative Concepts, Methods and Tools for Scientific Discovery in the Plant Sciences |
| title | When Chemistry Meets Biology - Generating Innovative Concepts, Methods and Tools for Scientific Discovery in the Plant Sciences |
| title_full | When Chemistry Meets Biology - Generating Innovative Concepts, Methods and Tools for Scientific Discovery in the Plant Sciences |
| title_fullStr | When Chemistry Meets Biology - Generating Innovative Concepts, Methods and Tools for Scientific Discovery in the Plant Sciences |
| title_full_unstemmed | When Chemistry Meets Biology - Generating Innovative Concepts, Methods and Tools for Scientific Discovery in the Plant Sciences |
| title_short | When Chemistry Meets Biology - Generating Innovative Concepts, Methods and Tools for Scientific Discovery in the Plant Sciences |
| title_sort | when chemistry meets biology generating innovative concepts methods and tools for scientific discovery in the plant sciences |
| topic | QK1-989 Q1-390 Plant-pathogen interaction High-Throughput Screening agricultural biotechnology plant growth regulator Chemical Genetics bioactive small molecule Target identification Chemical Biology Plant immune response phytohormone thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences |
| topic_facet | QK1-989 Q1-390 Plant-pathogen interaction High-Throughput Screening agricultural biotechnology plant growth regulator Chemical Genetics bioactive small molecule Target identification Chemical Biology Plant immune response phytohormone thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences |
| url | 18315 |
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