Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture
This book considers mainly etiology, pathogenesis, and pathophysiology of aortic aneurysms (AA) and aneurysm rupture and addresses anyone engaged in treatment and prevention of AA. Multiple factors are implicated in AA pathogenesis, and are outlined here in detail by a team of specialist researchers...
Zapisane w:
| Format: | Online |
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| Język: | angielski |
| Wydane: |
IntechOpen
2021
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| Hasła przedmiotowe: | |
| Dostęp online: | ONIX_20210420_9789533075235_384 |
| Etykiety: |
Nie ma etykietki, Dołącz pierwszą etykiete!
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| _version_ | 1869528875320475648 |
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| collection | Directory of Open Access Books |
| description | This book considers mainly etiology, pathogenesis, and pathophysiology of aortic aneurysms (AA) and aneurysm rupture and addresses anyone engaged in treatment and prevention of AA. Multiple factors are implicated in AA pathogenesis, and are outlined here in detail by a team of specialist researchers. Initial pathological events in AA involve recruitment and infiltration of leukocytes into the aortic adventitia and media, which are associated with the production of inflammatory cytokines, chemokine, and reactive oxygen species. AA development is characterized by elastin fragmentation. As the aorta dilates due to loss of elastin and attenuation of the media, the arterial wall thickens as a result of remodeling. Collagen synthesis increases during the early stages of aneurysm formation, suggesting a repair process, but resulting in a less distensible vessel. Proteases identified in excess in AA and other aortic diseases include matrix metalloproteinases (MMPs), cathepsins, chymase and others. The elucidation of these issues will identify new targets for prophylactic and therapeutic intervention. |
| format | Online |
| id | doab-20.500.12854ir-65028 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-650282024-03-31T22:44:04Z Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture Grundmann, Reinhart Cardiovascular medicine thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJD Cardiovascular medicine This book considers mainly etiology, pathogenesis, and pathophysiology of aortic aneurysms (AA) and aneurysm rupture and addresses anyone engaged in treatment and prevention of AA. Multiple factors are implicated in AA pathogenesis, and are outlined here in detail by a team of specialist researchers. Initial pathological events in AA involve recruitment and infiltration of leukocytes into the aortic adventitia and media, which are associated with the production of inflammatory cytokines, chemokine, and reactive oxygen species. AA development is characterized by elastin fragmentation. As the aorta dilates due to loss of elastin and attenuation of the media, the arterial wall thickens as a result of remodeling. Collagen synthesis increases during the early stages of aneurysm formation, suggesting a repair process, but resulting in a less distensible vessel. Proteases identified in excess in AA and other aortic diseases include matrix metalloproteinases (MMPs), cathepsins, chymase and others. The elucidation of these issues will identify new targets for prophylactic and therapeutic intervention. 2021-04-20T15:07:19Z 2021-04-20T15:07:19Z 2011 book ONIX_20210420_9789533075235_384 9789533075235 9789535164401 https://directory.doabooks.org/handle/20.500.12854/65028 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/484/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/995 10.5772/995 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789533075235 9789535164401 IntechOpen 234 open access |
| spellingShingle | Cardiovascular medicine thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJD Cardiovascular medicine Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture |
| title | Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture |
| title_full | Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture |
| title_fullStr | Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture |
| title_full_unstemmed | Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture |
| title_short | Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture |
| title_sort | etiology pathogenesis and pathophysiology of aortic aneurysms and aneurysm rupture |
| topic | Cardiovascular medicine thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJD Cardiovascular medicine |
| topic_facet | Cardiovascular medicine thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJD Cardiovascular medicine |
| url | ONIX_20210420_9789533075235_384 |