Role of the Adipocyte in Development of Type 2 Diabetes
Adipocytes are important in the body for maintaining proper energy balance by storing excess energy as triglycerides. However, efforts of the last decade have identified several molecules that are secreted from adipocytes, such as leptin, which are involved in signaling between tissues and organs. T...
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| Aineistotyyppi: | Online |
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| Kieli: | englanti |
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IntechOpen
2021
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| Linkit: | ONIX_20210420_9789533075983_512 |
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| _version_ | 1869519499800084480 |
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| collection | Directory of Open Access Books |
| description | Adipocytes are important in the body for maintaining proper energy balance by storing excess energy as triglycerides. However, efforts of the last decade have identified several molecules that are secreted from adipocytes, such as leptin, which are involved in signaling between tissues and organs. These adipokines are important in overall regulation of energy metabolism and can regulate body composition as well as glucose homeostasis. Excess lipid storage in tissues other than adipose can result in development of diabetes and nonalcoholic fatty liver disease (NAFLD). In this book we review the role of adipocytes in development of insulin resistance, type 2 diabetes and NAFLD. Because type 2 diabetes has been suggested to be a disease of inflammation we included several chapters on the mechanism of inflammation modulating organ injury. Finally, we conclude with a review on exercise and nutrient regulation for the treatment of type 2 diabetes and its co-morbidities. |
| format | Online |
| id | doab-20.500.12854ir-65155 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-651552024-03-31T22:44:14Z Role of the Adipocyte in Development of Type 2 Diabetes Croniger, Coleen Endocrinology thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJG Endocrinology Adipocytes are important in the body for maintaining proper energy balance by storing excess energy as triglycerides. However, efforts of the last decade have identified several molecules that are secreted from adipocytes, such as leptin, which are involved in signaling between tissues and organs. These adipokines are important in overall regulation of energy metabolism and can regulate body composition as well as glucose homeostasis. Excess lipid storage in tissues other than adipose can result in development of diabetes and nonalcoholic fatty liver disease (NAFLD). In this book we review the role of adipocytes in development of insulin resistance, type 2 diabetes and NAFLD. Because type 2 diabetes has been suggested to be a disease of inflammation we included several chapters on the mechanism of inflammation modulating organ injury. Finally, we conclude with a review on exercise and nutrient regulation for the treatment of type 2 diabetes and its co-morbidities. 2021-04-20T15:10:22Z 2021-04-20T15:10:22Z 2011 book ONIX_20210420_9789533075983_512 9789533075983 9789535164951 https://directory.doabooks.org/handle/20.500.12854/65155 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/1039/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/1543 10.5772/1543 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789533075983 9789535164951 IntechOpen 384 open access |
| spellingShingle | Endocrinology thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJG Endocrinology Role of the Adipocyte in Development of Type 2 Diabetes |
| title | Role of the Adipocyte in Development of Type 2 Diabetes |
| title_full | Role of the Adipocyte in Development of Type 2 Diabetes |
| title_fullStr | Role of the Adipocyte in Development of Type 2 Diabetes |
| title_full_unstemmed | Role of the Adipocyte in Development of Type 2 Diabetes |
| title_short | Role of the Adipocyte in Development of Type 2 Diabetes |
| title_sort | role of the adipocyte in development of type 2 diabetes |
| topic | Endocrinology thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJG Endocrinology |
| topic_facet | Endocrinology thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJG Endocrinology |
| url | ONIX_20210420_9789533075983_512 |