Treatment of Metastatic Melanoma
Surgery continues to be the mainstay treatment for melanoma localized to the primary tumor and/or lymph nodes. Results from randomized controlled trials indicate that sentinel node biopsy for the treatment of cutaneous melanoma of intermediate thickness has a beneficial effect on recurrence rates, a...
Saved in:
| Format: | Online |
|---|---|
| Language: | English |
| Published: |
IntechOpen
2021
|
| Subjects: | |
| Online Access: | ONIX_20210420_9789533075747_550 |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1869521833019047936 |
|---|---|
| collection | Directory of Open Access Books |
| description | Surgery continues to be the mainstay treatment for melanoma localized to the primary tumor and/or lymph nodes. Results from randomized controlled trials indicate that sentinel node biopsy for the treatment of cutaneous melanoma of intermediate thickness has a beneficial effect on recurrence rates, and adjuvant radiotherapy to regional lymph node fields following surgical resection reduces loco-regional recurrence in patients at high risk of relapse. Isolated limb perfusion, electrochemotherapy, and photodynamic therapy continue to be evaluated for treatment of stage IV disease. However, the greatest excitement in new treatment has been with targeted therapies for genetic mutations. In particular, the promising results of partial and complete tumor response in stage IV disease from early phase trials of the B-RAF kinase inhibitors. This book provides a contemporary insight into the therapeutic treatment options for patients with metastatic melanoma and is relevant to clinicians and researchers worldwide. In addition, an update on current clinical trials for melanoma treatment has been included, and two chapters have been reserved to discuss the treatment of oral and uveal melanoma. |
| format | Online |
| id | doab-20.500.12854ir-65193 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-651932024-03-31T22:45:57Z Treatment of Metastatic Melanoma Morton, Rachael Oncology thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology Surgery continues to be the mainstay treatment for melanoma localized to the primary tumor and/or lymph nodes. Results from randomized controlled trials indicate that sentinel node biopsy for the treatment of cutaneous melanoma of intermediate thickness has a beneficial effect on recurrence rates, and adjuvant radiotherapy to regional lymph node fields following surgical resection reduces loco-regional recurrence in patients at high risk of relapse. Isolated limb perfusion, electrochemotherapy, and photodynamic therapy continue to be evaluated for treatment of stage IV disease. However, the greatest excitement in new treatment has been with targeted therapies for genetic mutations. In particular, the promising results of partial and complete tumor response in stage IV disease from early phase trials of the B-RAF kinase inhibitors. This book provides a contemporary insight into the therapeutic treatment options for patients with metastatic melanoma and is relevant to clinicians and researchers worldwide. In addition, an update on current clinical trials for melanoma treatment has been included, and two chapters have been reserved to discuss the treatment of oral and uveal melanoma. 2021-04-20T15:11:15Z 2021-04-20T15:11:15Z 2011 book ONIX_20210420_9789533075747_550 9789533075747 9789535165132 https://directory.doabooks.org/handle/20.500.12854/65193 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/523/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/1034 10.5772/1034 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789533075747 9789535165132 IntechOpen 362 open access |
| spellingShingle | Oncology thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology Treatment of Metastatic Melanoma |
| title | Treatment of Metastatic Melanoma |
| title_full | Treatment of Metastatic Melanoma |
| title_fullStr | Treatment of Metastatic Melanoma |
| title_full_unstemmed | Treatment of Metastatic Melanoma |
| title_short | Treatment of Metastatic Melanoma |
| title_sort | treatment of metastatic melanoma |
| topic | Oncology thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| topic_facet | Oncology thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| url | ONIX_20210420_9789533075747_550 |