Towards New Therapies for Parkinson's Disease
Parkinson's disease (PD) is characterised clinically by various non-motor and progressive motor symptoms, pathologically by loss of dopamine producing cells and intraneuronal cytoplasmic inclusions composed primarily of ?-synuclein. By the time a patient first presents with symptoms of Parkinson's d...
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| Format: | Online |
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| Idioma: | anglès |
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IntechOpen
2021
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| Accés en línia: | ONIX_20210420_9789533074634_610 |
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| description | Parkinson's disease (PD) is characterised clinically by various non-motor and progressive motor symptoms, pathologically by loss of dopamine producing cells and intraneuronal cytoplasmic inclusions composed primarily of ?-synuclein. By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a significant proportion of the cells in the substantia nigra have already been destroyed. This degeneration progresses despite the current therapies until the cell loss is so great that the quality of normal life is compromised. The dopamine precursor levodopa is the most valuable drug currently available for the treatment of PD. However for most PD patients, the optimal clinical benefit from levodopa decreases around five to six years of treatment. The aim of the chapters of this book is to work towards an understanding in the mechanisms of degeneration and to develop disease modifying therapies. |
| format | Online |
| id | doab-20.500.12854ir-65253 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-652532024-03-29T08:03:32Z Towards New Therapies for Parkinson's Disease Finkelstein, David I. Physiological & neuro-psychology, biopsychology bic Book Industry Communication::J Society & social sciences::JM Psychology::JMM Physiological & neuro-psychology, biopsychology thema EDItEUR::J Society and Social Sciences::JM Psychology::JMM Physiological and neuro-psychology, biopsychology Parkinson's disease (PD) is characterised clinically by various non-motor and progressive motor symptoms, pathologically by loss of dopamine producing cells and intraneuronal cytoplasmic inclusions composed primarily of ?-synuclein. By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a significant proportion of the cells in the substantia nigra have already been destroyed. This degeneration progresses despite the current therapies until the cell loss is so great that the quality of normal life is compromised. The dopamine precursor levodopa is the most valuable drug currently available for the treatment of PD. However for most PD patients, the optimal clinical benefit from levodopa decreases around five to six years of treatment. The aim of the chapters of this book is to work towards an understanding in the mechanisms of degeneration and to develop disease modifying therapies. 2021-04-20T15:12:50Z 2021-04-20T15:12:50Z 2011 book ONIX_20210420_9789533074634_610 9789533074634 9789535165453 https://directory.doabooks.org/handle/20.500.12854/65253 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/437/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/954 10.5772/954 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789533074634 9789535165453 IntechOpen 410 open access |
| spellingShingle | Physiological & neuro-psychology, biopsychology bic Book Industry Communication::J Society & social sciences::JM Psychology::JMM Physiological & neuro-psychology, biopsychology thema EDItEUR::J Society and Social Sciences::JM Psychology::JMM Physiological and neuro-psychology, biopsychology Towards New Therapies for Parkinson's Disease |
| title | Towards New Therapies for Parkinson's Disease |
| title_full | Towards New Therapies for Parkinson's Disease |
| title_fullStr | Towards New Therapies for Parkinson's Disease |
| title_full_unstemmed | Towards New Therapies for Parkinson's Disease |
| title_short | Towards New Therapies for Parkinson's Disease |
| title_sort | towards new therapies for parkinson s disease |
| topic | Physiological & neuro-psychology, biopsychology bic Book Industry Communication::J Society & social sciences::JM Psychology::JMM Physiological & neuro-psychology, biopsychology thema EDItEUR::J Society and Social Sciences::JM Psychology::JMM Physiological and neuro-psychology, biopsychology |
| topic_facet | Physiological & neuro-psychology, biopsychology bic Book Industry Communication::J Society & social sciences::JM Psychology::JMM Physiological & neuro-psychology, biopsychology thema EDItEUR::J Society and Social Sciences::JM Psychology::JMM Physiological and neuro-psychology, biopsychology |
| url | ONIX_20210420_9789533074634_610 |