Bacterial Artificial Chromosomes
This book focuses on the numerous applications of Bacterial Artificial Chromosomes (BACs) in a variety of studies. The topics reviewed range from using BAC libraries as resources for marsupial and monotreme gene mapping and comparative genomic studies, to using BACs as vehicles for maintaining the l...
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| Formato: | Online |
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| Idioma: | inglês |
| Publicado em: |
IntechOpen
2021
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| Acesso em linha: | ONIX_20210420_9789533077253_686 |
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| _version_ | 1869515104991576064 |
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| collection | Directory of Open Access Books |
| description | This book focuses on the numerous applications of Bacterial Artificial Chromosomes (BACs) in a variety of studies. The topics reviewed range from using BAC libraries as resources for marsupial and monotreme gene mapping and comparative genomic studies, to using BACs as vehicles for maintaining the large infectious DNA genomes of viruses. The large size of the insert DNA in BACs and the ease of engineering mutations in that DNA within the bacterial host, allowed manipulating the BAC-viral DNA of Varicella-Zoster Virus. Other reviews include the maintenance and suitable expression of foreign genes from a Baculovirus genome, including protein complexes, from the BAC-viral DNA and generating vaccines from BAC-viral DNA genomes of Marek's disease virus. Production of multi-purpose BAC clones in the novel Bacillus subtilis host is described, along with chapters that illustrate the use of BAC transgenic animals to address important issues of gene regulation in vertebrates, such as functionally identifying novel cis-acting distal gene regulatory sequences. |
| format | Online |
| id | doab-20.500.12854ir-65329 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-653292024-04-05T17:30:59Z Bacterial Artificial Chromosomes Chatterjee, Pradeep Bacteriology (non-medical) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) This book focuses on the numerous applications of Bacterial Artificial Chromosomes (BACs) in a variety of studies. The topics reviewed range from using BAC libraries as resources for marsupial and monotreme gene mapping and comparative genomic studies, to using BACs as vehicles for maintaining the large infectious DNA genomes of viruses. The large size of the insert DNA in BACs and the ease of engineering mutations in that DNA within the bacterial host, allowed manipulating the BAC-viral DNA of Varicella-Zoster Virus. Other reviews include the maintenance and suitable expression of foreign genes from a Baculovirus genome, including protein complexes, from the BAC-viral DNA and generating vaccines from BAC-viral DNA genomes of Marek's disease virus. Production of multi-purpose BAC clones in the novel Bacillus subtilis host is described, along with chapters that illustrate the use of BAC transgenic animals to address important issues of gene regulation in vertebrates, such as functionally identifying novel cis-acting distal gene regulatory sequences. 2021-04-20T15:14:39Z 2021-04-20T15:14:39Z 2011 book ONIX_20210420_9789533077253_686 9789533077253 9789535151753 https://directory.doabooks.org/handle/20.500.12854/65329 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/554/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/1064 10.5772/1064 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789533077253 9789535151753 IntechOpen 150 open access |
| spellingShingle | Bacteriology (non-medical) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) Bacterial Artificial Chromosomes |
| title | Bacterial Artificial Chromosomes |
| title_full | Bacterial Artificial Chromosomes |
| title_fullStr | Bacterial Artificial Chromosomes |
| title_full_unstemmed | Bacterial Artificial Chromosomes |
| title_short | Bacterial Artificial Chromosomes |
| title_sort | bacterial artificial chromosomes |
| topic | Bacteriology (non-medical) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| topic_facet | Bacteriology (non-medical) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| url | ONIX_20210420_9789533077253_686 |