Mechanisms in Parkinson's Disease
Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key mole...
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| Formato: | Online |
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| Idioma: | inglés |
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IntechOpen
2021
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| Acceso en liña: | ONIX_20210420_9789533078762_889 |
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| _version_ | 1869525397704540160 |
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| collection | Directory of Open Access Books |
| description | Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular mechanisms that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD pathogenesis. Previously implicated culprits in PD neurodegeneration, mitochondrial dysfunction, and oxidative stress may also act in part by causing the accumulation of misfolded proteins, in addition to producing other deleterious events in dopaminergic neurons. Neurotoxin-based models have been important in elucidating the molecular cascade of cell death in dopaminergic neurons. PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process. |
| format | Online |
| id | doab-20.500.12854ir-65532 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-655322024-04-01T14:15:18Z Mechanisms in Parkinson's Disease Dushanova, Juliana Neurology & clinical neurophysiology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular mechanisms that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD pathogenesis. Previously implicated culprits in PD neurodegeneration, mitochondrial dysfunction, and oxidative stress may also act in part by causing the accumulation of misfolded proteins, in addition to producing other deleterious events in dopaminergic neurons. Neurotoxin-based models have been important in elucidating the molecular cascade of cell death in dopaminergic neurons. PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process. 2021-04-20T15:19:39Z 2021-04-20T15:19:39Z 2012 book ONIX_20210420_9789533078762_889 9789533078762 9789535167419 https://directory.doabooks.org/handle/20.500.12854/65532 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/1360/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/1826 10.5772/1826 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789533078762 9789535167419 IntechOpen 606 open access |
| spellingShingle | Neurology & clinical neurophysiology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology Mechanisms in Parkinson's Disease |
| title | Mechanisms in Parkinson's Disease |
| title_full | Mechanisms in Parkinson's Disease |
| title_fullStr | Mechanisms in Parkinson's Disease |
| title_full_unstemmed | Mechanisms in Parkinson's Disease |
| title_short | Mechanisms in Parkinson's Disease |
| title_sort | mechanisms in parkinson s disease |
| topic | Neurology & clinical neurophysiology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology |
| topic_facet | Neurology & clinical neurophysiology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology |
| url | ONIX_20210420_9789533078762_889 |