Chronic Lymphocytic Leukemia
B-cell chronic lymphocytic leukemia (CLL) is considered a single disease with extremely variable course, and survival rates ranging from months to decades. It is clear that clinical heterogeneity reflects biologic diversity with at least two major subtypes in terms of cellular proliferation, clinica...
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| Formato: | Online |
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| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2021
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| Materias: | |
| Acceso en línea: | ONIX_20210420_9789533078816_904 |
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| _version_ | 1869518084772986880 |
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| collection | Directory of Open Access Books |
| description | B-cell chronic lymphocytic leukemia (CLL) is considered a single disease with extremely variable course, and survival rates ranging from months to decades. It is clear that clinical heterogeneity reflects biologic diversity with at least two major subtypes in terms of cellular proliferation, clinical aggressiveness and prognosis. As CLL progresses, abnormal hematopoiesis results in pancitopenia and decreased immunoglobulin production, followed by nonspecific symptoms such as fatigue or malaise. A cure is usually not possible, and delayed treatment (until symptoms develop) is aimed at lengthening life and decreasing symptoms. Researchers are playing a lead role in investigating CLL's cause and the role of genetics in the pathogenesis of this disorder. Research programs are dedicated towards understanding the basic mechanisms underlying CLL with the hope of improving treatment options. |
| format | Online |
| id | doab-20.500.12854ir-65547 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-655472024-03-31T22:43:59Z Chronic Lymphocytic Leukemia Oppezzo, Pablo Musculoskeletal medicine thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJD Cardiovascular medicine B-cell chronic lymphocytic leukemia (CLL) is considered a single disease with extremely variable course, and survival rates ranging from months to decades. It is clear that clinical heterogeneity reflects biologic diversity with at least two major subtypes in terms of cellular proliferation, clinical aggressiveness and prognosis. As CLL progresses, abnormal hematopoiesis results in pancitopenia and decreased immunoglobulin production, followed by nonspecific symptoms such as fatigue or malaise. A cure is usually not possible, and delayed treatment (until symptoms develop) is aimed at lengthening life and decreasing symptoms. Researchers are playing a lead role in investigating CLL's cause and the role of genetics in the pathogenesis of this disorder. Research programs are dedicated towards understanding the basic mechanisms underlying CLL with the hope of improving treatment options. 2021-04-20T15:20:00Z 2021-04-20T15:20:00Z 2012 book ONIX_20210420_9789533078816_904 9789533078816 9789535167464 https://directory.doabooks.org/handle/20.500.12854/65547 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/647/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/1156 10.5772/1156 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789533078816 9789535167464 IntechOpen 464 open access |
| spellingShingle | Musculoskeletal medicine thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJD Cardiovascular medicine Chronic Lymphocytic Leukemia |
| title | Chronic Lymphocytic Leukemia |
| title_full | Chronic Lymphocytic Leukemia |
| title_fullStr | Chronic Lymphocytic Leukemia |
| title_full_unstemmed | Chronic Lymphocytic Leukemia |
| title_short | Chronic Lymphocytic Leukemia |
| title_sort | chronic lymphocytic leukemia |
| topic | Musculoskeletal medicine thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJD Cardiovascular medicine |
| topic_facet | Musculoskeletal medicine thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJD Cardiovascular medicine |
| url | ONIX_20210420_9789533078816_904 |