Frontiers in Radiation Oncology
The mode of action by radiation is postulated to be the production of double strand breaks of DNA. The repair of double strand breaks occurs through non homologous end joining through acetylation of histone proteins by histone acetyltransferases (HATs). The fixation of double strand breaks through H...
Sábháilte in:
| Formáid: | Online |
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| Teanga: | Béarla |
| Foilsithe / Cruthaithe: |
IntechOpen
2021
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| Ábhair: | |
| Rochtain ar líne: | ONIX_20210420_9789535111634_1934 |
| Clibeanna: |
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
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| _version_ | 1869529045022015488 |
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| collection | Directory of Open Access Books |
| description | The mode of action by radiation is postulated to be the production of double strand breaks of DNA. The repair of double strand breaks occurs through non homologous end joining through acetylation of histone proteins by histone acetyltransferases (HATs). The fixation of double strand breaks through HAT inhibitors is a promising application for radiation sensitization in the clinic. P53 is a tumour suppressor gene and its mutation has been implicated in 60% of human cancers. As one of the pivotal anticancer genes, P53 controls the transcription and translation of a series of genes. The kinetics of DNA double strand break generation and their co relation to P53 status, ATM and ARF activation are computed and modelled for understanding the potential of such research. |
| format | Online |
| id | doab-20.500.12854ir-66575 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-665752024-03-31T22:43:40Z Frontiers in Radiation Oncology Kataria, Tejinder Radiotherapy thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology The mode of action by radiation is postulated to be the production of double strand breaks of DNA. The repair of double strand breaks occurs through non homologous end joining through acetylation of histone proteins by histone acetyltransferases (HATs). The fixation of double strand breaks through HAT inhibitors is a promising application for radiation sensitization in the clinic. P53 is a tumour suppressor gene and its mutation has been implicated in 60% of human cancers. As one of the pivotal anticancer genes, P53 controls the transcription and translation of a series of genes. The kinetics of DNA double strand break generation and their co relation to P53 status, ATM and ARF activation are computed and modelled for understanding the potential of such research. 2021-04-20T15:47:13Z 2021-04-20T15:47:13Z 2013 book ONIX_20210420_9789535111634_1934 9789535111634 9789535171706 https://directory.doabooks.org/handle/20.500.12854/66575 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/2693/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/3065 10.5772/3065 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789535111634 9789535171706 IntechOpen 228 open access |
| spellingShingle | Radiotherapy thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology Frontiers in Radiation Oncology |
| title | Frontiers in Radiation Oncology |
| title_full | Frontiers in Radiation Oncology |
| title_fullStr | Frontiers in Radiation Oncology |
| title_full_unstemmed | Frontiers in Radiation Oncology |
| title_short | Frontiers in Radiation Oncology |
| title_sort | frontiers in radiation oncology |
| topic | Radiotherapy thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| topic_facet | Radiotherapy thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| url | ONIX_20210420_9789535111634_1934 |