Alzheimer's Disease
There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description,...
Zapisane w:
| Format: | Online |
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| Język: | angielski |
| Wydane: |
IntechOpen
2021
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| Hasła przedmiotowe: | |
| Dostęp online: | ONIX_20210420_9789535121374_2066 |
| Etykiety: |
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| _version_ | 1869518242244984832 |
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| collection | Directory of Open Access Books |
| description | There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially. Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension. The role of lipids and cholesterol has been recognized, but the relevant pathogenetic steps are still to be identified. There is an urgent need to understand molecular disease pathogenesis in order to develop early therapeutic targets for the disease. |
| format | Online |
| id | doab-20.500.12854ir-66707 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-667072024-04-01T14:15:14Z Alzheimer's Disease Zerr, Inga Neurology & clinical neurophysiology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially. Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension. The role of lipids and cholesterol has been recognized, but the relevant pathogenetic steps are still to be identified. There is an urgent need to understand molecular disease pathogenesis in order to develop early therapeutic targets for the disease. 2021-04-20T15:51:11Z 2021-04-20T15:51:11Z 2015 book ONIX_20210420_9789535121374_2066 9789535121374 9789535172420 https://directory.doabooks.org/handle/20.500.12854/66707 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/4543/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/58663 10.5772/58663 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9789535121374 9789535172420 IntechOpen 372 open access |
| spellingShingle | Neurology & clinical neurophysiology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology Alzheimer's Disease |
| title | Alzheimer's Disease |
| title_full | Alzheimer's Disease |
| title_fullStr | Alzheimer's Disease |
| title_full_unstemmed | Alzheimer's Disease |
| title_short | Alzheimer's Disease |
| title_sort | alzheimer s disease |
| topic | Neurology & clinical neurophysiology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology |
| topic_facet | Neurology & clinical neurophysiology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology |
| url | ONIX_20210420_9789535121374_2066 |