Prions
The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic di...
Furkejuvvon:
| Materiálatiipa: | Online |
|---|---|
| Giella: | eaŋgalasgiella |
| Almmustuhtton: |
IntechOpen
2021
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| Fáttát: | |
| Liŋkkat: | ONIX_20210420_9781789850185_2314 |
| Fáddágilkorat: |
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| _version_ | 1869531226462748672 |
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| collection | Directory of Open Access Books |
| description | The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE - neurotoxicity, loss of anti-inflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE. |
| format | Online |
| id | doab-20.500.12854ir-66955 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-669552024-03-31T22:45:48Z Prions Nikolaev Sirakov, Ivo Infectious & contagious diseases thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE - neurotoxicity, loss of anti-inflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE. 2021-04-20T15:58:32Z 2021-04-20T15:58:32Z 2019 book ONIX_20210420_9781789850185_2314 9781789850185 9781789850178 9781838817688 https://directory.doabooks.org/handle/20.500.12854/66955 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/7209/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/intechopen.74080 10.5772/intechopen.74080 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9781789850185 9781789850178 9781838817688 IntechOpen 82 open access |
| spellingShingle | Infectious & contagious diseases thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases Prions |
| title | Prions |
| title_full | Prions |
| title_fullStr | Prions |
| title_full_unstemmed | Prions |
| title_short | Prions |
| title_sort | prions |
| topic | Infectious & contagious diseases thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases |
| topic_facet | Infectious & contagious diseases thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases |
| url | ONIX_20210420_9781789850185_2314 |