Genes and Cancer
Cancer is a malignant tumor caused by DNA damage, which leads to uncontrolled cell growth. Tumor progression is locally favored by the mitogenic effects of hormones or growth factors, which stimulate the tumor's growth, or the activation of vascular endothelial growth factor receptor, which induces...
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| Médium: | Online |
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| Jazyk: | angličtina |
| Vydáno: |
IntechOpen
2021
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| Témata: | |
| On-line přístup: | ONIX_20210420_9781789844276_2364 |
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| _version_ | 1869517048207376384 |
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| collection | Directory of Open Access Books |
| description | Cancer is a malignant tumor caused by DNA damage, which leads to uncontrolled cell growth. Tumor progression is locally favored by the mitogenic effects of hormones or growth factors, which stimulate the tumor's growth, or the activation of vascular endothelial growth factor receptor, which induces angiogenesis and leads to metastasis. About 300 out of 25,000 genes that set up the human genome are involved in cancer pathology. These genes are divided into three groups: oncogenes, tumor suppressor genes, and DNA repair genes. Activated oncogenes promote the development of cancer, whereas the tumor suppressor and DNA repair genes have a protective role by respectively inhibiting cell cycle progression and inducing apoptosis, or by repairing DNA damage occurring during the cell cycle. This book discusses the issue of tumor suppressor genes through chapters written by experts using advanced biochemistry, cell, and molecular biology tools. The tumor suppressor genes can be used as markers of risk to identify populations with high risk or targets for cancer treatment and therapeutic resistance. We hope that the work provided in this book will be useful for researchers and students and will increase knowledge of the understanding of cancer and improve its treatment. |
| format | Online |
| id | doab-20.500.12854ir-67005 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-670052024-03-31T22:45:21Z Genes and Cancer Lemamy, Guy-Joseph Medical genetics thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics Cancer is a malignant tumor caused by DNA damage, which leads to uncontrolled cell growth. Tumor progression is locally favored by the mitogenic effects of hormones or growth factors, which stimulate the tumor's growth, or the activation of vascular endothelial growth factor receptor, which induces angiogenesis and leads to metastasis. About 300 out of 25,000 genes that set up the human genome are involved in cancer pathology. These genes are divided into three groups: oncogenes, tumor suppressor genes, and DNA repair genes. Activated oncogenes promote the development of cancer, whereas the tumor suppressor and DNA repair genes have a protective role by respectively inhibiting cell cycle progression and inducing apoptosis, or by repairing DNA damage occurring during the cell cycle. This book discusses the issue of tumor suppressor genes through chapters written by experts using advanced biochemistry, cell, and molecular biology tools. The tumor suppressor genes can be used as markers of risk to identify populations with high risk or targets for cancer treatment and therapeutic resistance. We hope that the work provided in this book will be useful for researchers and students and will increase knowledge of the understanding of cancer and improve its treatment. 2021-04-20T15:59:58Z 2021-04-20T15:59:58Z 2019 book ONIX_20210420_9781789844276_2364 9781789844276 9781789844269 9781838819743 https://directory.doabooks.org/handle/20.500.12854/67005 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/8171/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/intechopen.78120 10.5772/intechopen.78120 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9781789844276 9781789844269 9781838819743 IntechOpen 126 open access |
| spellingShingle | Medical genetics thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics Genes and Cancer |
| title | Genes and Cancer |
| title_full | Genes and Cancer |
| title_fullStr | Genes and Cancer |
| title_full_unstemmed | Genes and Cancer |
| title_short | Genes and Cancer |
| title_sort | genes and cancer |
| topic | Medical genetics thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics |
| topic_facet | Medical genetics thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics |
| url | ONIX_20210420_9781789844276_2364 |