Tyrosine Kinases as Druggable Targets in Cancer
Protein tyrosine kinase (PTK) deregulation contributes to growth of cancer and many other diseases. The development of small-molecule tyrosine kinase inhibitors (TKIs) that target the deregulated PTKs, such as epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) and Bcr-ABL...
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| Materyal Türü: | Online |
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| Dil: | İngilizce |
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IntechOpen
2021
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| Online Erişim: | ONIX_20210420_9781789848090_2372 |
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| _version_ | 1869527394536128512 |
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| collection | Directory of Open Access Books |
| description | Protein tyrosine kinase (PTK) deregulation contributes to growth of cancer and many other diseases. The development of small-molecule tyrosine kinase inhibitors (TKIs) that target the deregulated PTKs, such as epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) and Bcr-ABL in chronic myeloid leukemia (CML), has revolutionized disease management. In this book, we examine a few aspects of PTKs and cancer, considering efficacy, predictive markers to therapeutic response, limitations, and future directions in TKI treatment. In this rapidly evolving field, overcoming therapeutic resistance is most challenging, and multi-targeting directs the next-generation TKIs and combination therapy as ongoing strategies in cancer treatment. |
| format | Online |
| id | doab-20.500.12854ir-67013 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-670132024-03-31T22:43:37Z Tyrosine Kinases as Druggable Targets in Cancer Ren, Huan Oncology thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology Protein tyrosine kinase (PTK) deregulation contributes to growth of cancer and many other diseases. The development of small-molecule tyrosine kinase inhibitors (TKIs) that target the deregulated PTKs, such as epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) and Bcr-ABL in chronic myeloid leukemia (CML), has revolutionized disease management. In this book, we examine a few aspects of PTKs and cancer, considering efficacy, predictive markers to therapeutic response, limitations, and future directions in TKI treatment. In this rapidly evolving field, overcoming therapeutic resistance is most challenging, and multi-targeting directs the next-generation TKIs and combination therapy as ongoing strategies in cancer treatment. 2021-04-20T16:00:12Z 2021-04-20T16:00:12Z 2019 book ONIX_20210420_9781789848090_2372 9781789848090 9781789848083 9781839622199 https://directory.doabooks.org/handle/20.500.12854/67013 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/8660/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/intechopen.79884 10.5772/intechopen.79884 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9781789848090 9781789848083 9781839622199 IntechOpen 134 open access |
| spellingShingle | Oncology thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology Tyrosine Kinases as Druggable Targets in Cancer |
| title | Tyrosine Kinases as Druggable Targets in Cancer |
| title_full | Tyrosine Kinases as Druggable Targets in Cancer |
| title_fullStr | Tyrosine Kinases as Druggable Targets in Cancer |
| title_full_unstemmed | Tyrosine Kinases as Druggable Targets in Cancer |
| title_short | Tyrosine Kinases as Druggable Targets in Cancer |
| title_sort | tyrosine kinases as druggable targets in cancer |
| topic | Oncology thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| topic_facet | Oncology thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology |
| url | ONIX_20210420_9781789848090_2372 |