Biology of <em>Trypanosoma cruzi</em>
Trypanosoma cruzi, an important zoonotic protozoan that causes Chagas disease, affects at least 8 million people in Latin America. Chagas disease is an important life-long infection in humans that can be divided into distinct clinical stages: the acute phase, where patient symptoms can vary from asy...
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| Formaat: | Online |
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| Taal: | Engels |
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IntechOpen
2021
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| Online toegang: | ONIX_20210420_9781839682049_2536 |
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| description | Trypanosoma cruzi, an important zoonotic protozoan that causes Chagas disease, affects at least 8 million people in Latin America. Chagas disease is an important life-long infection in humans that can be divided into distinct clinical stages: the acute phase, where patient symptoms can vary from asymptomatic to severe; the indeterminate form, which is usually asymptomatic; and the chronic phase, where cardiomyopathy and/or digestive megasyndromes appear. In addition to its medical importance, T. cruzi is an interesting biological model for studying processes such as: (1) cell differentiation, where a non-infective stage transforms into an infective one; (2) cell invasion, where the infective stages are able to penetrate into a mammalian host cell, where they multiply several times and thus amplify the infection; and (3) evasion from the immune system, using several mechanisms. This book, with 13 chapters, has been organized in four major sections: 1. "Basic Biology," 2. "Biochemistry and Molecular Biology," 3. "Parasite"Host Cell Interaction," and 4 "Chemotherapy." The chapters include basic biological information on the protozoan lifecycle, including new information on parasite genomics and proteomics. In addition, they analyze the interaction with host cells as well the immune response and evasion, ending with information on experimental chemotherapy against Chagas disease. |
| format | Online |
| id | doab-20.500.12854ir-67177 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-671772024-04-01T14:11:54Z Biology of <em>Trypanosoma cruzi</em> De Souza, Wanderley Medical parasitology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology Trypanosoma cruzi, an important zoonotic protozoan that causes Chagas disease, affects at least 8 million people in Latin America. Chagas disease is an important life-long infection in humans that can be divided into distinct clinical stages: the acute phase, where patient symptoms can vary from asymptomatic to severe; the indeterminate form, which is usually asymptomatic; and the chronic phase, where cardiomyopathy and/or digestive megasyndromes appear. In addition to its medical importance, T. cruzi is an interesting biological model for studying processes such as: (1) cell differentiation, where a non-infective stage transforms into an infective one; (2) cell invasion, where the infective stages are able to penetrate into a mammalian host cell, where they multiply several times and thus amplify the infection; and (3) evasion from the immune system, using several mechanisms. This book, with 13 chapters, has been organized in four major sections: 1. "Basic Biology," 2. "Biochemistry and Molecular Biology," 3. "Parasite"Host Cell Interaction," and 4 "Chemotherapy." The chapters include basic biological information on the protozoan lifecycle, including new information on parasite genomics and proteomics. In addition, they analyze the interaction with host cells as well the immune response and evasion, ending with information on experimental chemotherapy against Chagas disease. 2021-04-20T16:05:29Z 2021-04-20T16:05:29Z 2019 book ONIX_20210420_9781839682049_2536 9781839682049 9781839682032 9781839682056 https://directory.doabooks.org/handle/20.500.12854/67177 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/8806/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/intechopen.80373 10.5772/intechopen.80373 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9781839682049 9781839682032 9781839682056 IntechOpen 234 open access |
| spellingShingle | Medical parasitology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology Biology of <em>Trypanosoma cruzi</em> |
| title | Biology of <em>Trypanosoma cruzi</em> |
| title_full | Biology of <em>Trypanosoma cruzi</em> |
| title_fullStr | Biology of <em>Trypanosoma cruzi</em> |
| title_full_unstemmed | Biology of <em>Trypanosoma cruzi</em> |
| title_short | Biology of <em>Trypanosoma cruzi</em> |
| title_sort | biology of em trypanosoma cruzi em |
| topic | Medical parasitology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology |
| topic_facet | Medical parasitology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology |
| url | ONIX_20210420_9781839682049_2536 |