Lipid Peroxidation Research
Lipid peroxidation is the major molecular mechanism that induces oxidative damage to cell structures and is also involved in the toxicity process that leads to cell death.Lipid peroxidation is a chain reaction initiated by the hydrogen abstraction or addition of an oxygen radical, resulting in the o...
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| Format: | Online |
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| Language: | English |
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IntechOpen
2021
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| Online Access: | ONIX_20210420_9781839685484_2582 |
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| description | Lipid peroxidation is the major molecular mechanism that induces oxidative damage to cell structures and is also involved in the toxicity process that leads to cell death.Lipid peroxidation is a chain reaction initiated by the hydrogen abstraction or addition of an oxygen radical, resulting in the oxidative damage of polyunsaturated fatty acids (PUFA). PUFAs are more sensitive than saturated fatty acids because of the presence of a double bond adjacent to a methylene group that makes the methylene C-H bond weaker and therefore the hydrogen is more susceptible to abstraction. This leaves an unpaired electron on the carbon, forming a carbon-centered radical, which is stabilized by a molecular rearrangement of the double bonds to form a conjugated diene, which then combines with oxygen to form a peroxy-radical.In pathological situations the reactive oxygen and nitrogen species are generated at higher than normal rates, and as a consequence, lipid peroxidation occurs with deficiency of endogenous antioxidants as alpha-tocopherol deficiency or reduced glutathione. In addition to containing high concentrations of PUFAs and transition metals, biological membranes of cells and organelles are constantly being subjected to various types of damage.This book presents systematic and comprehensive reviews on free radicals and their involvement in lipid peroxidation with special emphasis on their important role in different diseases. |
| format | Online |
| id | doab-20.500.12854ir-67223 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
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| spelling | doab-20.500.12854ir-672232024-04-05T17:30:52Z Lipid Peroxidation Research Ahmed Mansour, Mahmoud Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Lipid peroxidation is the major molecular mechanism that induces oxidative damage to cell structures and is also involved in the toxicity process that leads to cell death.Lipid peroxidation is a chain reaction initiated by the hydrogen abstraction or addition of an oxygen radical, resulting in the oxidative damage of polyunsaturated fatty acids (PUFA). PUFAs are more sensitive than saturated fatty acids because of the presence of a double bond adjacent to a methylene group that makes the methylene C-H bond weaker and therefore the hydrogen is more susceptible to abstraction. This leaves an unpaired electron on the carbon, forming a carbon-centered radical, which is stabilized by a molecular rearrangement of the double bonds to form a conjugated diene, which then combines with oxygen to form a peroxy-radical.In pathological situations the reactive oxygen and nitrogen species are generated at higher than normal rates, and as a consequence, lipid peroxidation occurs with deficiency of endogenous antioxidants as alpha-tocopherol deficiency or reduced glutathione. In addition to containing high concentrations of PUFAs and transition metals, biological membranes of cells and organelles are constantly being subjected to various types of damage.This book presents systematic and comprehensive reviews on free radicals and their involvement in lipid peroxidation with special emphasis on their important role in different diseases. 2021-04-20T16:06:56Z 2021-04-20T16:06:56Z 2020 book ONIX_20210420_9781839685484_2582 9781839685484 9781839685477 9781839685491 https://directory.doabooks.org/handle/20.500.12854/67223 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/6966/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/intechopen.73713 10.5772/intechopen.73713 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9781839685484 9781839685477 9781839685491 IntechOpen 128 open access |
| spellingShingle | Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Lipid Peroxidation Research |
| title | Lipid Peroxidation Research |
| title_full | Lipid Peroxidation Research |
| title_fullStr | Lipid Peroxidation Research |
| title_full_unstemmed | Lipid Peroxidation Research |
| title_short | Lipid Peroxidation Research |
| title_sort | lipid peroxidation research |
| topic | Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| topic_facet | Molecular biology thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| url | ONIX_20210420_9781839685484_2582 |