Chromatin and Epigenetics
Genomics has gathered broad public attention since Lamarck put forward his top-down hypothesis of 'motivated change' in 1809 in his famous book "Philosophie Zoologique" and even more so since Darwin published his famous bottom-up theory of natural selection in "The Origin of Species" in 1859. The pu...
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| Format: | Online |
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| Język: | angielski |
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IntechOpen
2021
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| Hasła przedmiotowe: | |
| Dostęp online: | ONIX_20210420_9781789844931_2604 |
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| _version_ | 1869525152061980672 |
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| collection | Directory of Open Access Books |
| description | Genomics has gathered broad public attention since Lamarck put forward his top-down hypothesis of 'motivated change' in 1809 in his famous book "Philosophie Zoologique" and even more so since Darwin published his famous bottom-up theory of natural selection in "The Origin of Species" in 1859. The public awareness culminated in the much anticipated race to decipher the sequence of the human genome in 2002. Over all those years, it has become apparent that genomic DNA is compacted into chromatin with a dedicated 3D higher-order organization and dynamics, and that on each structural level epigenetic modifications exist. The book "Chromatin and Epigenetics" addresses current issues in the fields of epigenetics and chromatin ranging from more theoretical overviews in the first four chapters to much more detailed methodologies and insights into diagnostics and treatments in the following chapters. The chapters illustrate in their depth and breadth that genetic information is stored on all structural and dynamical levels within the nucleus with corresponding modifications of functional relevance. Thus, only an integrative systems approach allows to understand, treat, and manipulate the holistic interplay of genotype and phenotype creating functional genomes. The book chapters therefore contribute to this general perspective, not only opening opportunities for a true universal view on genetic information but also being key for a general understanding of genomes, their function, as well as life and evolution in general. |
| format | Online |
| id | doab-20.500.12854ir-67245 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-672452024-03-31T22:45:27Z Chromatin and Epigenetics Logie, Colin Aurelius Knoch, Tobias Medical genetics thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics Genomics has gathered broad public attention since Lamarck put forward his top-down hypothesis of 'motivated change' in 1809 in his famous book "Philosophie Zoologique" and even more so since Darwin published his famous bottom-up theory of natural selection in "The Origin of Species" in 1859. The public awareness culminated in the much anticipated race to decipher the sequence of the human genome in 2002. Over all those years, it has become apparent that genomic DNA is compacted into chromatin with a dedicated 3D higher-order organization and dynamics, and that on each structural level epigenetic modifications exist. The book "Chromatin and Epigenetics" addresses current issues in the fields of epigenetics and chromatin ranging from more theoretical overviews in the first four chapters to much more detailed methodologies and insights into diagnostics and treatments in the following chapters. The chapters illustrate in their depth and breadth that genetic information is stored on all structural and dynamical levels within the nucleus with corresponding modifications of functional relevance. Thus, only an integrative systems approach allows to understand, treat, and manipulate the holistic interplay of genotype and phenotype creating functional genomes. The book chapters therefore contribute to this general perspective, not only opening opportunities for a true universal view on genetic information but also being key for a general understanding of genomes, their function, as well as life and evolution in general. 2021-04-20T16:07:48Z 2021-04-20T16:07:48Z 2020 book ONIX_20210420_9781789844931_2604 9781789844931 9781789844924 9781789849820 https://directory.doabooks.org/handle/20.500.12854/67245 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/6582/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/intechopen.71387 10.5772/intechopen.71387 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9781789844931 9781789844924 9781789849820 IntechOpen 294 open access |
| spellingShingle | Medical genetics thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics Chromatin and Epigenetics |
| title | Chromatin and Epigenetics |
| title_full | Chromatin and Epigenetics |
| title_fullStr | Chromatin and Epigenetics |
| title_full_unstemmed | Chromatin and Epigenetics |
| title_short | Chromatin and Epigenetics |
| title_sort | chromatin and epigenetics |
| topic | Medical genetics thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics |
| topic_facet | Medical genetics thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics |
| url | ONIX_20210420_9781789844931_2604 |