Xenotransplantation
Recently, remarkable progress has been made in the area of preclinical xenotransplantation experiments. Surprisingly, a heterotopic heart from the gene-editing pig continued to beat for almost 2.5 years, when implanted in the monkey abdomen, and a pig life-supporting kidney could also function for o...
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| Μορφή: | Online |
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| Γλώσσα: | Αγγλικά |
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IntechOpen
2021
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| Διαθέσιμο Online: | ONIX_20210420_9781789856644_2694 |
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| _version_ | 1869522902016065536 |
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| collection | Directory of Open Access Books |
| description | Recently, remarkable progress has been made in the area of preclinical xenotransplantation experiments. Surprisingly, a heterotopic heart from the gene-editing pig continued to beat for almost 2.5 years, when implanted in the monkey abdomen, and a pig life-supporting kidney could also function for over 1.3 years in monkeys. Concerning islets, islets from gene-editing pigs could work for more than one year in monkeys. It is noteworthy that one group reported a survival of adult wild-type pig islets of over 600 days. On the other hand, the progress in these preclinical trials strongly affected not only the xenotransplantation study itself but regeneration studies to use pigs as a scaffold to foster human induced pluripotent stem cells. |
| format | Online |
| id | doab-20.500.12854ir-67335 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-673352024-04-01T14:12:13Z Xenotransplantation Miyagawa, Shuji Biomedical engineering thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQW Biomedical engineering Recently, remarkable progress has been made in the area of preclinical xenotransplantation experiments. Surprisingly, a heterotopic heart from the gene-editing pig continued to beat for almost 2.5 years, when implanted in the monkey abdomen, and a pig life-supporting kidney could also function for over 1.3 years in monkeys. Concerning islets, islets from gene-editing pigs could work for more than one year in monkeys. It is noteworthy that one group reported a survival of adult wild-type pig islets of over 600 days. On the other hand, the progress in these preclinical trials strongly affected not only the xenotransplantation study itself but regeneration studies to use pigs as a scaffold to foster human induced pluripotent stem cells. 2021-04-20T16:10:42Z 2021-04-20T16:10:42Z 2020 book ONIX_20210420_9781789856644_2694 9781789856644 9781789856637 9781789845211 https://directory.doabooks.org/handle/20.500.12854/67335 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/8093/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/intechopen.77924 10.5772/intechopen.77924 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9781789856644 9781789856637 9781789845211 IntechOpen 156 open access |
| spellingShingle | Biomedical engineering thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQW Biomedical engineering Xenotransplantation |
| title | Xenotransplantation |
| title_full | Xenotransplantation |
| title_fullStr | Xenotransplantation |
| title_full_unstemmed | Xenotransplantation |
| title_short | Xenotransplantation |
| title_sort | xenotransplantation |
| topic | Biomedical engineering thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQW Biomedical engineering |
| topic_facet | Biomedical engineering thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQW Biomedical engineering |
| url | ONIX_20210420_9781789856644_2694 |