Mitochondria and Brain Disorders
The mitochondrion is a unique and ubiquitous organelle that contains its own genome, encoding essential proteins that are major components of the respiratory chain and energy production system. Mitochondria play a dominant role in the life and function of eukaryotic cells including neurons and glia,...
Guardado en:
| Formato: | Online |
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| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2021
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| Materias: | |
| Acceso en línea: | ONIX_20210420_9781789855326_2707 |
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| _version_ | 1869526821629853696 |
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| collection | Directory of Open Access Books |
| description | The mitochondrion is a unique and ubiquitous organelle that contains its own genome, encoding essential proteins that are major components of the respiratory chain and energy production system. Mitochondria play a dominant role in the life and function of eukaryotic cells including neurons and glia, as their survival and activity depend upon mitochondrial energy production and supply. Besides energy production, mitochondria also play a vital role in calcium homeostasis and may induce apoptosis by excitotoxicity. Mitochondrial dysfunction is related to common neurological diseases, such as Parkinson's disease, Alzheimer's disease, Friedreich's ataxia, Huntington's disease, and Multiple Sclerosis. An efficient treatment of mitochondrial dysfunction would open new horizons in the therapeutic perspectives of a substantial number of inflammatory and degenerative neurological disorders. |
| format | Online |
| id | doab-20.500.12854ir-67348 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-673482024-03-31T22:45:28Z Mitochondria and Brain Disorders Baloyannis, Stavros Medical genetics thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics The mitochondrion is a unique and ubiquitous organelle that contains its own genome, encoding essential proteins that are major components of the respiratory chain and energy production system. Mitochondria play a dominant role in the life and function of eukaryotic cells including neurons and glia, as their survival and activity depend upon mitochondrial energy production and supply. Besides energy production, mitochondria also play a vital role in calcium homeostasis and may induce apoptosis by excitotoxicity. Mitochondrial dysfunction is related to common neurological diseases, such as Parkinson's disease, Alzheimer's disease, Friedreich's ataxia, Huntington's disease, and Multiple Sclerosis. An efficient treatment of mitochondrial dysfunction would open new horizons in the therapeutic perspectives of a substantial number of inflammatory and degenerative neurological disorders. 2021-04-20T16:11:06Z 2021-04-20T16:11:06Z 2020 book ONIX_20210420_9781789855326_2707 9781789855326 9781789855319 9781789856538 https://directory.doabooks.org/handle/20.500.12854/67348 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/7850/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/intechopen.77668 10.5772/intechopen.77668 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9781789855326 9781789855319 9781789856538 IntechOpen 124 open access |
| spellingShingle | Medical genetics thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics Mitochondria and Brain Disorders |
| title | Mitochondria and Brain Disorders |
| title_full | Mitochondria and Brain Disorders |
| title_fullStr | Mitochondria and Brain Disorders |
| title_full_unstemmed | Mitochondria and Brain Disorders |
| title_short | Mitochondria and Brain Disorders |
| title_sort | mitochondria and brain disorders |
| topic | Medical genetics thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics |
| topic_facet | Medical genetics thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics |
| url | ONIX_20210420_9781789855326_2707 |