Synucleins
Neurodegenerative diseases are debilitating conditions that result in degeneration and death of nerve cells. A significant group of these diseases is the synucleinopathies, which are characterized by the accumulation of aggregates of alpha-synuclein in neurons, nerve fibers, or glial cells. There ar...
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| Materialtyp: | Online |
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| Språk: | engelska |
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IntechOpen
2021
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| Länkar: | ONIX_20210420_9781789845884_2784 |
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| _version_ | 1869519210968776704 |
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| collection | Directory of Open Access Books |
| description | Neurodegenerative diseases are debilitating conditions that result in degeneration and death of nerve cells. A significant group of these diseases is the synucleinopathies, which are characterized by the accumulation of aggregates of alpha-synuclein in neurons, nerve fibers, or glial cells. There are three main types of synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Synucleins are small, naturally unfolded proteins prone to aggregate and form intracellular inclusions, which impair normal cellular functions. This book presents new data on synuclein aggregation and its effect on cholesterol transport. It also discusses the role of genetic contribution to these diseases and approaches to inhibition of synuclein aggregation. |
| format | Online |
| id | doab-20.500.12854ir-67425 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-674252024-04-05T12:35:57Z Synucleins Surguchov, Andrei Neurosciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Neurodegenerative diseases are debilitating conditions that result in degeneration and death of nerve cells. A significant group of these diseases is the synucleinopathies, which are characterized by the accumulation of aggregates of alpha-synuclein in neurons, nerve fibers, or glial cells. There are three main types of synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Synucleins are small, naturally unfolded proteins prone to aggregate and form intracellular inclusions, which impair normal cellular functions. This book presents new data on synuclein aggregation and its effect on cholesterol transport. It also discusses the role of genetic contribution to these diseases and approaches to inhibition of synuclein aggregation. 2021-04-20T16:13:31Z 2021-04-20T16:13:31Z 2020 book ONIX_20210420_9781789845884_2784 9781789845884 9781789845655 9781789845891 https://directory.doabooks.org/handle/20.500.12854/67425 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/6998/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/intechopen.73750 10.5772/intechopen.73750 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9781789845884 9781789845655 9781789845891 IntechOpen 96 open access |
| spellingShingle | Neurosciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Synucleins |
| title | Synucleins |
| title_full | Synucleins |
| title_fullStr | Synucleins |
| title_full_unstemmed | Synucleins |
| title_short | Synucleins |
| title_sort | synucleins |
| topic | Neurosciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | Neurosciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | ONIX_20210420_9781789845884_2784 |