Amyotrophic Lateral Sclerosis
A flurry of recent research on the role of the RNA/DNA-binding proteins TDP-43 and FUS as well as a dozen other factors (e.g., C9ORF72 and profilin) has led to a new paradigm in our understanding of the pathobiology of the motor neuron disease, Amyotrophic Lateral Sclerosis (ALS). How these factors...
Đã lưu trong:
| Định dạng: | Online |
|---|---|
| Ngôn ngữ: | Tiếng Anh |
| Được phát hành: |
IntechOpen
2021
|
| Những chủ đề: | |
| Truy cập trực tuyến: | ONIX_20210420_9781838805814_2998 |
| Các nhãn: |
Không có thẻ, Là người đầu tiên thẻ bản ghi này!
|
| _version_ | 1869518618028408832 |
|---|---|
| collection | Directory of Open Access Books |
| description | A flurry of recent research on the role of the RNA/DNA-binding proteins TDP-43 and FUS as well as a dozen other factors (e.g., C9ORF72 and profilin) has led to a new paradigm in our understanding of the pathobiology of the motor neuron disease, Amyotrophic Lateral Sclerosis (ALS). How these factors trigger neuromuscular dysfunction is critical for developing more effective ALS therapeutics. The ‘gain-of-toxicity’ or ‘loss-of-function’ of these etiological factors is a key question. Recent studies on the imbalance in genome damage versus repair have opened avenues for potential DNA repair-based therapeutics. This book highlights emerging science in the area of ALS and discusses key approaches and mechanisms essential for developing a cure for ALS. |
| format | Online |
| id | doab-20.500.12854ir-67638 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-676382024-04-01T14:15:14Z Amyotrophic Lateral Sclerosis Hegde, Muralidhar L. Neurology & clinical neurophysiology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology A flurry of recent research on the role of the RNA/DNA-binding proteins TDP-43 and FUS as well as a dozen other factors (e.g., C9ORF72 and profilin) has led to a new paradigm in our understanding of the pathobiology of the motor neuron disease, Amyotrophic Lateral Sclerosis (ALS). How these factors trigger neuromuscular dysfunction is critical for developing more effective ALS therapeutics. The ‘gain-of-toxicity’ or ‘loss-of-function’ of these etiological factors is a key question. Recent studies on the imbalance in genome damage versus repair have opened avenues for potential DNA repair-based therapeutics. This book highlights emerging science in the area of ALS and discusses key approaches and mechanisms essential for developing a cure for ALS. 2021-04-20T16:20:34Z 2021-04-20T16:20:34Z 2020 book ONIX_20210420_9781838805814_2998 9781838805814 9781838805807 9781838805821 https://directory.doabooks.org/handle/20.500.12854/67638 eng image/jpeg n/a https://www.intechopen.com/books https://mts.intechopen.com/storage/books/8172/authors_book/authors_book.pdf IntechOpen IntechOpen 10.5772/intechopen.78121 10.5772/intechopen.78121 78a36484-2c0c-47cb-ad67-2b9f5cd4a8f6 9781838805814 9781838805807 9781838805821 IntechOpen 160 open access |
| spellingShingle | Neurology & clinical neurophysiology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology Amyotrophic Lateral Sclerosis |
| title | Amyotrophic Lateral Sclerosis |
| title_full | Amyotrophic Lateral Sclerosis |
| title_fullStr | Amyotrophic Lateral Sclerosis |
| title_full_unstemmed | Amyotrophic Lateral Sclerosis |
| title_short | Amyotrophic Lateral Sclerosis |
| title_sort | amyotrophic lateral sclerosis |
| topic | Neurology & clinical neurophysiology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology |
| topic_facet | Neurology & clinical neurophysiology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology |
| url | ONIX_20210420_9781838805814_2998 |