Characterization and Clinical Management of Dilated Cardiomyopathy
Dilated cardiomyopathy (DCM) is a particular phenotype of non-ischemic systolic heart failure, frequently recognizing a genetic background and affecting relatively young patients with few comorbidities. Nowadays, long-term survival of DCM patients has been markedly improved due to an early diagnosis...
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| Formato: | Online |
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| Idioma: | inglés |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Acceso en liña: | ONIX_20210501_9783039437610_26 |
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| collection | Directory of Open Access Books |
| description | Dilated cardiomyopathy (DCM) is a particular phenotype of non-ischemic systolic heart failure, frequently recognizing a genetic background and affecting relatively young patients with few comorbidities. Nowadays, long-term survival of DCM patients has been markedly improved due to an early diagnosis and uninterrupted and tailored follow-up under constant optimal medical and non-pharmacological evidence-based treatments. Nevertheless, DCM is still one of the most common causes of heart transplantation in the western world. Clinical management requires an integrated and systematic use of diagnostic tools and a deeper investigation of the basic mechanisms underlying the disease. However, several emerging issues remain debated. Specifically, the genotype–phenotype correlation, the role of advanced imaging techniques and genetic testing, the lack of appropriate risk stratification models, the need for a multiparametric and multidisciplinary approach for device implantation, and a continuous reclassification of the disease during follow-up remain challenging issues in clinical practice. Therefore, the aim of this Special Issue is to shed the light on the most recent advancements in characterization and clinical management of DCM in order to unveil the conundrum of this particular disease. |
| format | Online |
| id | doab-20.500.12854ir-68283 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-682832024-03-30T23:21:48Z Characterization and Clinical Management of Dilated Cardiomyopathy Merlo, Marco SCN5A cardiac sodium channel cardiac channelopathy dilated cardiomyopathy precision medicine arrhythmias atrial fibrillation cardiomyopathy heart failure supraventricular arrhythmia systolic dysfunction tachycardiomyopathy ventricular arrhythmia left atrial strain cardiac resynchronization therapy muscular dystrophy calcium heart gene therapy phospholamban Serca2a mdx oxidative stress membrane stabilization left ventricular noncompaction congenital heart disease congestive heart failure non-ischemic cardiomyopathy genetics desmin mitochondrial dysfunction myopathy whole exome sequencing laminopathy LMNA biomarkers troponin T NT-proBNP malignant ventricular arrhythmia arrhythmic risk stratification DNA methylation alternative splicing epigenetics nonischemic dilated cardiomyopathy cardiac magnetic resonance imaging late gadolinium enhancement long axis strain left ventricle sphericity index major adverse cardiovascular events sex differences left ventricular reverse remodelling long-term outcomes left ventricle non-compaction cardiomyopathy cardiac magnetic resonance titin RNA binding motif protein 20 (RBM20) sarcomere diastolic dysfunction phosphorylation non-sense mRNA decay mammalian target of rapamycin (mTOR) complex-1 duchenne muscular distrophy n/a thema EDItEUR::M Medicine and Nursing Dilated cardiomyopathy (DCM) is a particular phenotype of non-ischemic systolic heart failure, frequently recognizing a genetic background and affecting relatively young patients with few comorbidities. Nowadays, long-term survival of DCM patients has been markedly improved due to an early diagnosis and uninterrupted and tailored follow-up under constant optimal medical and non-pharmacological evidence-based treatments. Nevertheless, DCM is still one of the most common causes of heart transplantation in the western world. Clinical management requires an integrated and systematic use of diagnostic tools and a deeper investigation of the basic mechanisms underlying the disease. However, several emerging issues remain debated. Specifically, the genotype–phenotype correlation, the role of advanced imaging techniques and genetic testing, the lack of appropriate risk stratification models, the need for a multiparametric and multidisciplinary approach for device implantation, and a continuous reclassification of the disease during follow-up remain challenging issues in clinical practice. Therefore, the aim of this Special Issue is to shed the light on the most recent advancements in characterization and clinical management of DCM in order to unveil the conundrum of this particular disease. 2021-05-01T15:06:06Z 2021-05-01T15:06:06Z 2021 book ONIX_20210501_9783039437610_26 9783039437610 9783039437627 https://directory.doabooks.org/handle/20.500.12854/68283 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/3292 https://mdpi.com/books/pdfview/book/3292 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03943-762-7 10.3390/books978-3-03943-762-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039437610 9783039437627 232 Basel, Switzerland open access |
| spellingShingle | SCN5A cardiac sodium channel cardiac channelopathy dilated cardiomyopathy precision medicine arrhythmias atrial fibrillation cardiomyopathy heart failure supraventricular arrhythmia systolic dysfunction tachycardiomyopathy ventricular arrhythmia left atrial strain cardiac resynchronization therapy muscular dystrophy calcium heart gene therapy phospholamban Serca2a mdx oxidative stress membrane stabilization left ventricular noncompaction congenital heart disease congestive heart failure non-ischemic cardiomyopathy genetics desmin mitochondrial dysfunction myopathy whole exome sequencing laminopathy LMNA biomarkers troponin T NT-proBNP malignant ventricular arrhythmia arrhythmic risk stratification DNA methylation alternative splicing epigenetics nonischemic dilated cardiomyopathy cardiac magnetic resonance imaging late gadolinium enhancement long axis strain left ventricle sphericity index major adverse cardiovascular events sex differences left ventricular reverse remodelling long-term outcomes left ventricle non-compaction cardiomyopathy cardiac magnetic resonance titin RNA binding motif protein 20 (RBM20) sarcomere diastolic dysfunction phosphorylation non-sense mRNA decay mammalian target of rapamycin (mTOR) complex-1 duchenne muscular distrophy n/a thema EDItEUR::M Medicine and Nursing Characterization and Clinical Management of Dilated Cardiomyopathy |
| title | Characterization and Clinical Management of Dilated Cardiomyopathy |
| title_full | Characterization and Clinical Management of Dilated Cardiomyopathy |
| title_fullStr | Characterization and Clinical Management of Dilated Cardiomyopathy |
| title_full_unstemmed | Characterization and Clinical Management of Dilated Cardiomyopathy |
| title_short | Characterization and Clinical Management of Dilated Cardiomyopathy |
| title_sort | characterization and clinical management of dilated cardiomyopathy |
| topic | SCN5A cardiac sodium channel cardiac channelopathy dilated cardiomyopathy precision medicine arrhythmias atrial fibrillation cardiomyopathy heart failure supraventricular arrhythmia systolic dysfunction tachycardiomyopathy ventricular arrhythmia left atrial strain cardiac resynchronization therapy muscular dystrophy calcium heart gene therapy phospholamban Serca2a mdx oxidative stress membrane stabilization left ventricular noncompaction congenital heart disease congestive heart failure non-ischemic cardiomyopathy genetics desmin mitochondrial dysfunction myopathy whole exome sequencing laminopathy LMNA biomarkers troponin T NT-proBNP malignant ventricular arrhythmia arrhythmic risk stratification DNA methylation alternative splicing epigenetics nonischemic dilated cardiomyopathy cardiac magnetic resonance imaging late gadolinium enhancement long axis strain left ventricle sphericity index major adverse cardiovascular events sex differences left ventricular reverse remodelling long-term outcomes left ventricle non-compaction cardiomyopathy cardiac magnetic resonance titin RNA binding motif protein 20 (RBM20) sarcomere diastolic dysfunction phosphorylation non-sense mRNA decay mammalian target of rapamycin (mTOR) complex-1 duchenne muscular distrophy n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | SCN5A cardiac sodium channel cardiac channelopathy dilated cardiomyopathy precision medicine arrhythmias atrial fibrillation cardiomyopathy heart failure supraventricular arrhythmia systolic dysfunction tachycardiomyopathy ventricular arrhythmia left atrial strain cardiac resynchronization therapy muscular dystrophy calcium heart gene therapy phospholamban Serca2a mdx oxidative stress membrane stabilization left ventricular noncompaction congenital heart disease congestive heart failure non-ischemic cardiomyopathy genetics desmin mitochondrial dysfunction myopathy whole exome sequencing laminopathy LMNA biomarkers troponin T NT-proBNP malignant ventricular arrhythmia arrhythmic risk stratification DNA methylation alternative splicing epigenetics nonischemic dilated cardiomyopathy cardiac magnetic resonance imaging late gadolinium enhancement long axis strain left ventricle sphericity index major adverse cardiovascular events sex differences left ventricular reverse remodelling long-term outcomes left ventricle non-compaction cardiomyopathy cardiac magnetic resonance titin RNA binding motif protein 20 (RBM20) sarcomere diastolic dysfunction phosphorylation non-sense mRNA decay mammalian target of rapamycin (mTOR) complex-1 duchenne muscular distrophy n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20210501_9783039437610_26 |