Clay-Based Pharmaceutical Formulations and Drug Delivery Systems
This book includes recent advances in the use of clays in the design of medicinal products and medicinal devices. The pharmaceutical applications of nanoclays are far ranging, because of their distinct advantages: they are versatile (possess a wide range of mechanical, chemical and physical properti...
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| Format: | Online |
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| Sprache: | Englisch |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Online-Zugang: | ONIX_20210501_9783036501864_55 |
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| collection | Directory of Open Access Books |
| description | This book includes recent advances in the use of clays in the design of medicinal products and medicinal devices. The pharmaceutical applications of nanoclays are far ranging, because of their distinct advantages: they are versatile (possess a wide range of mechanical, chemical and physical properties) and available at reasonable costs. Some special clays (mainly kaolinite, halloysite, montmorillonite, saponite, hectorite, palygorskite and sepiolite), as well as semi-synthetic (organoclays) or synthetic (double layer hydroxides) derivatives, are very useful materials for modulating drug delivery. In the last decade, several actives have been loaded onto nanoclays and similar inorganic excipients to increase solubility, improve stability, reduce toxicity, and enhance bioavailability, with a consequent increase in therapeutic response. Polymer/clay nanocomposites with synergic properties have been developed, showing improved mechanical properties with respect to the pristine polymer matrices and allowing modified release of loaded actives. Moreover, nanoclays have very recently demonstrated positive effects on the proliferation and migration of fibroblasts. The development of clay-based medicinal products and medicinal devices requires experience in the fields of both clay structure and properties and pharmaceutical technology design. |
| format | Online |
| id | doab-20.500.12854ir-68311 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-683112024-03-31T13:08:06Z Clay-Based Pharmaceutical Formulations and Drug Delivery Systems Viseras, César hydrochlorothiazide cyclodextrins sepiolite nanoclay dissolution rate tablet electrospinning chitosan chondroitin sulfate scaffolds montmorillonite halloysite fibroblasts proliferation immune response glycosaminoglycans antimicrobial properties palygorskite spring water hydrogel fibroblast biocompatibility wound healing mesoporous clay Neusilin aeroperl liquisolid technique glyburide dissolution improvement hydrotalcite ketoprofen hybrid photostability hydrogel film bioadhesion heavy metal hazardous element element mobility clay minerals toxicity palygorksite proliferation Franz cell bioactive elements praziquantel drug organic solvents in vitro dissolution tests cytotoxicity targeted drug delivery halloysite nanotube osteosarcoma methotrexate surface modification n/a thema EDItEUR::M Medicine and Nursing This book includes recent advances in the use of clays in the design of medicinal products and medicinal devices. The pharmaceutical applications of nanoclays are far ranging, because of their distinct advantages: they are versatile (possess a wide range of mechanical, chemical and physical properties) and available at reasonable costs. Some special clays (mainly kaolinite, halloysite, montmorillonite, saponite, hectorite, palygorskite and sepiolite), as well as semi-synthetic (organoclays) or synthetic (double layer hydroxides) derivatives, are very useful materials for modulating drug delivery. In the last decade, several actives have been loaded onto nanoclays and similar inorganic excipients to increase solubility, improve stability, reduce toxicity, and enhance bioavailability, with a consequent increase in therapeutic response. Polymer/clay nanocomposites with synergic properties have been developed, showing improved mechanical properties with respect to the pristine polymer matrices and allowing modified release of loaded actives. Moreover, nanoclays have very recently demonstrated positive effects on the proliferation and migration of fibroblasts. The development of clay-based medicinal products and medicinal devices requires experience in the fields of both clay structure and properties and pharmaceutical technology design. 2021-05-01T15:06:41Z 2021-05-01T15:06:41Z 2021 book ONIX_20210501_9783036501864_55 9783036501864 9783036501871 https://directory.doabooks.org/handle/20.500.12854/68311 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/3321 https://mdpi.com/books/pdfview/book/3321 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-0187-1 10.3390/books978-3-0365-0187-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036501864 9783036501871 202 Basel, Switzerland open access |
| spellingShingle | hydrochlorothiazide cyclodextrins sepiolite nanoclay dissolution rate tablet electrospinning chitosan chondroitin sulfate scaffolds montmorillonite halloysite fibroblasts proliferation immune response glycosaminoglycans antimicrobial properties palygorskite spring water hydrogel fibroblast biocompatibility wound healing mesoporous clay Neusilin aeroperl liquisolid technique glyburide dissolution improvement hydrotalcite ketoprofen hybrid photostability hydrogel film bioadhesion heavy metal hazardous element element mobility clay minerals toxicity palygorksite proliferation Franz cell bioactive elements praziquantel drug organic solvents in vitro dissolution tests cytotoxicity targeted drug delivery halloysite nanotube osteosarcoma methotrexate surface modification n/a thema EDItEUR::M Medicine and Nursing Clay-Based Pharmaceutical Formulations and Drug Delivery Systems |
| title | Clay-Based Pharmaceutical Formulations and Drug Delivery Systems |
| title_full | Clay-Based Pharmaceutical Formulations and Drug Delivery Systems |
| title_fullStr | Clay-Based Pharmaceutical Formulations and Drug Delivery Systems |
| title_full_unstemmed | Clay-Based Pharmaceutical Formulations and Drug Delivery Systems |
| title_short | Clay-Based Pharmaceutical Formulations and Drug Delivery Systems |
| title_sort | clay based pharmaceutical formulations and drug delivery systems |
| topic | hydrochlorothiazide cyclodextrins sepiolite nanoclay dissolution rate tablet electrospinning chitosan chondroitin sulfate scaffolds montmorillonite halloysite fibroblasts proliferation immune response glycosaminoglycans antimicrobial properties palygorskite spring water hydrogel fibroblast biocompatibility wound healing mesoporous clay Neusilin aeroperl liquisolid technique glyburide dissolution improvement hydrotalcite ketoprofen hybrid photostability hydrogel film bioadhesion heavy metal hazardous element element mobility clay minerals toxicity palygorksite proliferation Franz cell bioactive elements praziquantel drug organic solvents in vitro dissolution tests cytotoxicity targeted drug delivery halloysite nanotube osteosarcoma methotrexate surface modification n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | hydrochlorothiazide cyclodextrins sepiolite nanoclay dissolution rate tablet electrospinning chitosan chondroitin sulfate scaffolds montmorillonite halloysite fibroblasts proliferation immune response glycosaminoglycans antimicrobial properties palygorskite spring water hydrogel fibroblast biocompatibility wound healing mesoporous clay Neusilin aeroperl liquisolid technique glyburide dissolution improvement hydrotalcite ketoprofen hybrid photostability hydrogel film bioadhesion heavy metal hazardous element element mobility clay minerals toxicity palygorksite proliferation Franz cell bioactive elements praziquantel drug organic solvents in vitro dissolution tests cytotoxicity targeted drug delivery halloysite nanotube osteosarcoma methotrexate surface modification n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20210501_9783036501864_55 |