Eutectic Solvents
Natural deep eutectic solvents (NADES) are pharmaceutically accepted systems not only because they typically offer a serious enhancement of active pharmaceutical ingredient (API) solubility, but also due to their non-toxicity. This fortunate conjuncture allows for designing new media for escalation...
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| Format: | Online |
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| Language: | English |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Online Access: | ONIX_20210501_9783036500225_146 |
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| description | Natural deep eutectic solvents (NADES) are pharmaceutically accepted systems not only because they typically offer a serious enhancement of active pharmaceutical ingredient (API) solubility, but also due to their non-toxicity. This fortunate conjuncture allows for designing new media for escalation and controlled release of APIs. For example, composition optimisation of a series of NADES comprising choline chloride with multi-hydroxyl compounds was successfully performed for a set of sulphonamide-based drugs. These results confirmed that NADES in general, and the ones based on choline chloride and glycerol particularly, are an attractive alternative to traditional solvents for sulphonamide dissolution. Experiments augmented with in silico modelling can offer deeper insights into the thermodynamic characteristics of these systems and an explanation for the origin of the observed solubility enhancement. Research of this type offers universal resolutions to the problem of low solubility issues for many types of drugs. Of particular interest is that such screening is not restricted to artificial in vitro environments but can be also easily adopted for the study of modelled in vivo situations. One of very important and interesting examples is a new curcumin–NADES formulation preserving its beneficial properties even after dilution with FaSSIF solution, which mimicks intestinal absorption. |
| format | Online |
| id | doab-20.500.12854ir-68400 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-684002024-03-27T16:34:36Z Eutectic Solvents Cysewski, Piotr Jeliński, Tomasz deep eutectic solvents molecularly imprinted polymers extraction phenolic compounds antioxidant activity spruce bark phytomass valorization deep eutectic solvent composite resins hydrogen bond eutectic solvents natural deep eutectic solvents nanostructured ionic solvents neoteric solvents ionic liquids ionic liquid hybrid solvent CO2 solubility Henry’s constant viscosity thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general Natural deep eutectic solvents (NADES) are pharmaceutically accepted systems not only because they typically offer a serious enhancement of active pharmaceutical ingredient (API) solubility, but also due to their non-toxicity. This fortunate conjuncture allows for designing new media for escalation and controlled release of APIs. For example, composition optimisation of a series of NADES comprising choline chloride with multi-hydroxyl compounds was successfully performed for a set of sulphonamide-based drugs. These results confirmed that NADES in general, and the ones based on choline chloride and glycerol particularly, are an attractive alternative to traditional solvents for sulphonamide dissolution. Experiments augmented with in silico modelling can offer deeper insights into the thermodynamic characteristics of these systems and an explanation for the origin of the observed solubility enhancement. Research of this type offers universal resolutions to the problem of low solubility issues for many types of drugs. Of particular interest is that such screening is not restricted to artificial in vitro environments but can be also easily adopted for the study of modelled in vivo situations. One of very important and interesting examples is a new curcumin–NADES formulation preserving its beneficial properties even after dilution with FaSSIF solution, which mimicks intestinal absorption. 2021-05-01T15:08:56Z 2021-05-01T15:08:56Z 2021 book ONIX_20210501_9783036500225_146 9783036500225 9783036500232 https://directory.doabooks.org/handle/20.500.12854/68400 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/3416 https://mdpi.com/books/pdfview/book/3416 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-0023-2 10.3390/books978-3-0365-0023-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036500225 9783036500232 126 Basel, Switzerland open access |
| spellingShingle | deep eutectic solvents molecularly imprinted polymers extraction phenolic compounds antioxidant activity spruce bark phytomass valorization deep eutectic solvent composite resins hydrogen bond eutectic solvents natural deep eutectic solvents nanostructured ionic solvents neoteric solvents ionic liquids ionic liquid hybrid solvent CO2 solubility Henry’s constant viscosity thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general Eutectic Solvents |
| title | Eutectic Solvents |
| title_full | Eutectic Solvents |
| title_fullStr | Eutectic Solvents |
| title_full_unstemmed | Eutectic Solvents |
| title_short | Eutectic Solvents |
| title_sort | eutectic solvents |
| topic | deep eutectic solvents molecularly imprinted polymers extraction phenolic compounds antioxidant activity spruce bark phytomass valorization deep eutectic solvent composite resins hydrogen bond eutectic solvents natural deep eutectic solvents nanostructured ionic solvents neoteric solvents ionic liquids ionic liquid hybrid solvent CO2 solubility Henry’s constant viscosity thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general |
| topic_facet | deep eutectic solvents molecularly imprinted polymers extraction phenolic compounds antioxidant activity spruce bark phytomass valorization deep eutectic solvent composite resins hydrogen bond eutectic solvents natural deep eutectic solvents nanostructured ionic solvents neoteric solvents ionic liquids ionic liquid hybrid solvent CO2 solubility Henry’s constant viscosity thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general |
| url | ONIX_20210501_9783036500225_146 |