Toxins and Cancer Therapy
Cancer has been a patient-specific and difficult-to-treat disease for decades, resulting in more deaths since 1900 than all other diseases except cardiovascular diseases. As societies around the world continue to shift towards an aging population, the social and economic burden created by cancer wil...
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| Format: | Online |
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| Jezik: | angleščina |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Teme: | |
| Online dostop: | ONIX_20210501_9783036501901_165 |
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Brez oznak, prvi označite!
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| _version_ | 1869525431609196544 |
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| collection | Directory of Open Access Books |
| description | Cancer has been a patient-specific and difficult-to-treat disease for decades, resulting in more deaths since 1900 than all other diseases except cardiovascular diseases. As societies around the world continue to shift towards an aging population, the social and economic burden created by cancer will only rise in the coming decades, necessitating continued improvement in our cancer therapies. Remarkably, in the late 1800s, bone surgeon William Coley serendipitously discovered that bacteria could be administered to patients as an effective (and sometimes toxic) form of cancer therapy known as "Coley's Toxins". His discoveries unknowingly led to two fields of cancer therapy that have been in development for decades and are now leading to significant improvements in therapy for cancer patients: immune-based and toxin-based therapies for cancer. Articles included here discuss the discoveries that emerged from Coley's Toxins that enable us to harness the immune system and microbial toxins to combat cancers, as oncology shifts from a field dominated by chemotherapy for most of the 20th century to biologic therapies that will dominate the 21st century. |
| format | Online |
| id | doab-20.500.12854ir-68419 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-684192024-03-31T13:08:44Z Toxins and Cancer Therapy Snook, Adam E. immunotoxin ribotoxin α-sarcin RNase T1 furin intracellular trafficking colorectal cancer botulinum toxin botulinum neurotoxin cancer cancer cells neuropathic pain post-surgical pain parotid gland submaxillary gland gustatory hyperhidrosis sialocele parotid fistula immunotherapy vaccine immune checkpoint inhibitors adoptive cell therapy cytokine therapy Coley’s Toxins glioblastoma drug discovery cytotoxic necrotizing factor type 1 protein purification recombinant protein production shiga toxins Gb3/CD77 apoptosis ER stress autophagy Burkitt lymphoma n/a thema EDItEUR::M Medicine and Nursing Cancer has been a patient-specific and difficult-to-treat disease for decades, resulting in more deaths since 1900 than all other diseases except cardiovascular diseases. As societies around the world continue to shift towards an aging population, the social and economic burden created by cancer will only rise in the coming decades, necessitating continued improvement in our cancer therapies. Remarkably, in the late 1800s, bone surgeon William Coley serendipitously discovered that bacteria could be administered to patients as an effective (and sometimes toxic) form of cancer therapy known as "Coley's Toxins". His discoveries unknowingly led to two fields of cancer therapy that have been in development for decades and are now leading to significant improvements in therapy for cancer patients: immune-based and toxin-based therapies for cancer. Articles included here discuss the discoveries that emerged from Coley's Toxins that enable us to harness the immune system and microbial toxins to combat cancers, as oncology shifts from a field dominated by chemotherapy for most of the 20th century to biologic therapies that will dominate the 21st century. 2021-05-01T15:09:18Z 2021-05-01T15:09:18Z 2021 book ONIX_20210501_9783036501901_165 9783036501901 9783036501918 https://directory.doabooks.org/handle/20.500.12854/68419 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/3435 https://mdpi.com/books/pdfview/book/3435 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-0191-8 10.3390/books978-3-0365-0191-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036501901 9783036501918 104 Basel, Switzerland open access |
| spellingShingle | immunotoxin ribotoxin α-sarcin RNase T1 furin intracellular trafficking colorectal cancer botulinum toxin botulinum neurotoxin cancer cancer cells neuropathic pain post-surgical pain parotid gland submaxillary gland gustatory hyperhidrosis sialocele parotid fistula immunotherapy vaccine immune checkpoint inhibitors adoptive cell therapy cytokine therapy Coley’s Toxins glioblastoma drug discovery cytotoxic necrotizing factor type 1 protein purification recombinant protein production shiga toxins Gb3/CD77 apoptosis ER stress autophagy Burkitt lymphoma n/a thema EDItEUR::M Medicine and Nursing Toxins and Cancer Therapy |
| title | Toxins and Cancer Therapy |
| title_full | Toxins and Cancer Therapy |
| title_fullStr | Toxins and Cancer Therapy |
| title_full_unstemmed | Toxins and Cancer Therapy |
| title_short | Toxins and Cancer Therapy |
| title_sort | toxins and cancer therapy |
| topic | immunotoxin ribotoxin α-sarcin RNase T1 furin intracellular trafficking colorectal cancer botulinum toxin botulinum neurotoxin cancer cancer cells neuropathic pain post-surgical pain parotid gland submaxillary gland gustatory hyperhidrosis sialocele parotid fistula immunotherapy vaccine immune checkpoint inhibitors adoptive cell therapy cytokine therapy Coley’s Toxins glioblastoma drug discovery cytotoxic necrotizing factor type 1 protein purification recombinant protein production shiga toxins Gb3/CD77 apoptosis ER stress autophagy Burkitt lymphoma n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | immunotoxin ribotoxin α-sarcin RNase T1 furin intracellular trafficking colorectal cancer botulinum toxin botulinum neurotoxin cancer cancer cells neuropathic pain post-surgical pain parotid gland submaxillary gland gustatory hyperhidrosis sialocele parotid fistula immunotherapy vaccine immune checkpoint inhibitors adoptive cell therapy cytokine therapy Coley’s Toxins glioblastoma drug discovery cytotoxic necrotizing factor type 1 protein purification recombinant protein production shiga toxins Gb3/CD77 apoptosis ER stress autophagy Burkitt lymphoma n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20210501_9783036501901_165 |