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Comorbidities in Chronic Kidney Disease (CKD)

With a mean worldwide prevalence of 13%, chronic kidney disease imposes a massive health burden on our society. In addition to reduced kidney function, patients with chronic kidney disease increasingly suffer from cardiovascular diseases affecting the heart and vasculature. Cardiovascular diseases a...

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Format: Online
Sprog:engelsk
Udgivet: MDPI - Multidisciplinary Digital Publishing Institute 2021
Fag:
arterial stiffness
carotid–femoral pulse wave velocity
hemodialysis
p-cresyl sulfate
uremic toxins
arterial calcification
lipid metabolism
inflammation
coagulation
endothelial dysfunction
epigenetics
chronic kidney disease
uremic cardiopathy
left ventricular hypertrophy
phosphate
PTH
FGF23
klotho
sclerostin
chronodisruption
chronodisruptor
circadian rhythm
internal clock
uremia
uremic cardiomyopathy
organ crosstalk
cardiorenal syndrome
left-ventricular hypertrophy
heart failure
cardiac fibrosis
cardiovascular disease
vascular calcification
experimental rodent models
FGFG23
Klotho
Wnt/β-catenin
CKD
parathyroid hormone
secondary hyperparathyroidism
uremic toxin
ageing
end-stage kidney disease
premature ageing
senescence
bone
gut
cardiovascular
CKD–MBD
comorbidity
fibrosis
calcification
thema EDItEUR::M Medicine and Nursing
Online adgang:ONIX_20210501_9783039366682_167
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Summary:With a mean worldwide prevalence of 13%, chronic kidney disease imposes a massive health burden on our society. In addition to reduced kidney function, patients with chronic kidney disease increasingly suffer from cardiovascular diseases affecting the heart and vasculature. Cardiovascular diseases account for around half of the deaths of patients with advanced chronic kidney disease. However, therapeutic options are highly insufficient. The pathological mechanisms that underlie increased cardiovascular risk in patients with chronic kidney disease remain largely unknown. This Special Issue provides insights into comorbidities in CKD patients, mainly focused on increased cardiovascular risk, and summarizes current knowledge of underlying pathophysiological mechanisms.

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