Zika Virus and Host Interactions
Zika virus (ZIKV), one of the flavivirus family members transmitted by mosquitos, was declared a Public Health Emergency of International Concern by the WHO in February 2016 because of clusters of newborn microcephaly cases and other neurological disorders in Brazil. Most ZIKV infections result in a...
में बचाया:
| स्वरूप: | Online |
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| भाषा: | अंग्रेज़ी |
| प्रकाशित: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| विषय: | |
| ऑनलाइन पहुंच: | ONIX_20210501_9783039439492_257 |
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कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!
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| _version_ | 1869531622579109888 |
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| collection | Directory of Open Access Books |
| description | Zika virus (ZIKV), one of the flavivirus family members transmitted by mosquitos, was declared a Public Health Emergency of International Concern by the WHO in February 2016 because of clusters of newborn microcephaly cases and other neurological disorders in Brazil. Most ZIKV infections result in a self-limited flu-like febrile disease, however, if contracted during pregnancy, the virus can also infect fetuses and cause a spectrum of birth defects known as congenital Zika syndrome. To date, no vaccines or antiviral drugs are licensed for ZIKV, and the virus has spread and become endemic to many tropical and sub-tropical countries. Included in this book are thirteen reports addressing diverse aspects of ZIKV–host interactions. These studies range from basic science to clinical research. It is expected that findings from these studies will contribute to a better understanding of the host cells interacting with ZIKV, and may serve as the basis for new diagnostics, antiviral therapies, and vaccine design. |
| format | Online |
| id | doab-20.500.12854ir-68511 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-685112024-03-28T03:30:41Z Zika Virus and Host Interactions Hobman, Tom Kumar, Anil Limonta, Daniel Zika virus peroxisomes innate immune response interferon astrocytes fetal brain zika virus flaviviruses T cells host-pathogen interactions flavivirus tight junctions claudins ZO-1 blood-placental barrier placenta apoptosis viral replication Bcl-2 protein family ZIKV virus host interactions pathogenesis MR766 guinea pig subcutaneous vaginal sexual transmission virus transmission envelope protein glycosylation fusion loop viral fusion cell entry NS5 protein nuclear localization inflammation innate immunity extracellular vesicles cellular communication C6/36 cells human monocytes endothelial vascular cells protein–protein interaction non-structural viral proteins network JAK/STAT cytokine West Nile virus HSP90 NS5 virus–host interactions anti-viral signaling immune response inflammatory mediator Sertoli cells Leydig cells ZIKA virus arboviruses infertility IFN RIG-I MDA5 IFNAR1 zika host cell death peroxisome mosquito tight junction thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Zika virus (ZIKV), one of the flavivirus family members transmitted by mosquitos, was declared a Public Health Emergency of International Concern by the WHO in February 2016 because of clusters of newborn microcephaly cases and other neurological disorders in Brazil. Most ZIKV infections result in a self-limited flu-like febrile disease, however, if contracted during pregnancy, the virus can also infect fetuses and cause a spectrum of birth defects known as congenital Zika syndrome. To date, no vaccines or antiviral drugs are licensed for ZIKV, and the virus has spread and become endemic to many tropical and sub-tropical countries. Included in this book are thirteen reports addressing diverse aspects of ZIKV–host interactions. These studies range from basic science to clinical research. It is expected that findings from these studies will contribute to a better understanding of the host cells interacting with ZIKV, and may serve as the basis for new diagnostics, antiviral therapies, and vaccine design. 2021-05-01T15:11:41Z 2021-05-01T15:11:41Z 2021 book ONIX_20210501_9783039439492_257 9783039439492 9783039439508 https://directory.doabooks.org/handle/20.500.12854/68511 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/3531 https://mdpi.com/books/pdfview/book/3531 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03943-950-8 10.3390/books978-3-03943-950-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039439492 9783039439508 256 Basel, Switzerland open access |
| spellingShingle | Zika virus peroxisomes innate immune response interferon astrocytes fetal brain zika virus flaviviruses T cells host-pathogen interactions flavivirus tight junctions claudins ZO-1 blood-placental barrier placenta apoptosis viral replication Bcl-2 protein family ZIKV virus host interactions pathogenesis MR766 guinea pig subcutaneous vaginal sexual transmission virus transmission envelope protein glycosylation fusion loop viral fusion cell entry NS5 protein nuclear localization inflammation innate immunity extracellular vesicles cellular communication C6/36 cells human monocytes endothelial vascular cells protein–protein interaction non-structural viral proteins network JAK/STAT cytokine West Nile virus HSP90 NS5 virus–host interactions anti-viral signaling immune response inflammatory mediator Sertoli cells Leydig cells ZIKA virus arboviruses infertility IFN RIG-I MDA5 IFNAR1 zika host cell death peroxisome mosquito tight junction thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Zika Virus and Host Interactions |
| title | Zika Virus and Host Interactions |
| title_full | Zika Virus and Host Interactions |
| title_fullStr | Zika Virus and Host Interactions |
| title_full_unstemmed | Zika Virus and Host Interactions |
| title_short | Zika Virus and Host Interactions |
| title_sort | zika virus and host interactions |
| topic | Zika virus peroxisomes innate immune response interferon astrocytes fetal brain zika virus flaviviruses T cells host-pathogen interactions flavivirus tight junctions claudins ZO-1 blood-placental barrier placenta apoptosis viral replication Bcl-2 protein family ZIKV virus host interactions pathogenesis MR766 guinea pig subcutaneous vaginal sexual transmission virus transmission envelope protein glycosylation fusion loop viral fusion cell entry NS5 protein nuclear localization inflammation innate immunity extracellular vesicles cellular communication C6/36 cells human monocytes endothelial vascular cells protein–protein interaction non-structural viral proteins network JAK/STAT cytokine West Nile virus HSP90 NS5 virus–host interactions anti-viral signaling immune response inflammatory mediator Sertoli cells Leydig cells ZIKA virus arboviruses infertility IFN RIG-I MDA5 IFNAR1 zika host cell death peroxisome mosquito tight junction thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Zika virus peroxisomes innate immune response interferon astrocytes fetal brain zika virus flaviviruses T cells host-pathogen interactions flavivirus tight junctions claudins ZO-1 blood-placental barrier placenta apoptosis viral replication Bcl-2 protein family ZIKV virus host interactions pathogenesis MR766 guinea pig subcutaneous vaginal sexual transmission virus transmission envelope protein glycosylation fusion loop viral fusion cell entry NS5 protein nuclear localization inflammation innate immunity extracellular vesicles cellular communication C6/36 cells human monocytes endothelial vascular cells protein–protein interaction non-structural viral proteins network JAK/STAT cytokine West Nile virus HSP90 NS5 virus–host interactions anti-viral signaling immune response inflammatory mediator Sertoli cells Leydig cells ZIKA virus arboviruses infertility IFN RIG-I MDA5 IFNAR1 zika host cell death peroxisome mosquito tight junction thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20210501_9783039439492_257 |