Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases
Natural-based biomolecules continuously play an important role in novel drug discovery for the treatment of chronic diseases. The development of natural peptide/protein-based, toxin-based, and antibody-based drugs can significantly improve the biomedical efficiency of disease-specific therapy. The f...
Saved in:
| Format: | Online |
|---|---|
| Language: | English |
| Published: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
|
| Subjects: | |
| Online Access: | ONIX_20210501_9783036503868_266 |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1869521246274715648 |
|---|---|
| collection | Directory of Open Access Books |
| description | Natural-based biomolecules continuously play an important role in novel drug discovery for the treatment of chronic diseases. The development of natural peptide/protein-based, toxin-based, and antibody-based drugs can significantly improve the biomedical efficiency of disease-specific therapy. The focus of this Special Issue of Biomolecules will be on the most recent advances related to novel peptides/proteins, antibodies, and toxins as forms of medicinal therapy. Recent advances in the discovery and development of these natural biomolecules for use in targeted therapy and immunotherapy against chronic diseases (e.g., cancer, diabetes, cardiovascular diseases, and rheumatoid arthritis) will be addressed. The discussion on using novel disease-specific proteins/peptides/toxins/antibodies along with currently available FDA-approved drugs as combinatorial treatments will also be encouraged in this context. Finally, an overview of some of the selected promising natural biomolecules that are potentially able to address the forthcoming challenges in this field will be included. Both research (in particular) and review articles proposing novelties or overviews, respectively, are welcome. |
| format | Online |
| id | doab-20.500.12854ir-68520 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-685202024-04-01T23:19:22Z Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases Kwok, Hang Fai DAPK1 SUMO SENP protein degradation post-translational modification amphibian Bowman-Birk inhibitor Tat peptide molecular cloning antifungal drug design protease inhibitor natural-based compound anticancer therapy lung cancer survivin apoptosis STAT3 colorectal cancer orientin cell cycle arrest Bcl-2 family proteins Astragalus membranaceus insulin PI3K AKT PPARγ PDX-1 Petasites japonicus Asteraceae lignan anti-inflammation NO PGE2 iNOS COX-2 molecular docking peptides kynurenines binding affinity μ-opioid receptor pharmacophore G-protein activation fucoidan PLGA docetaxel drug delivery system anticancer therapy/cancer treatment hIAPP amyloidogenesis insulin granules endoplasmic reticulum anionic lipids F23R variant β-sheet transitions β-cell cytotoxicity unfolded protein response pomegranate punicalagin tannins gingiva fibroblasts antioxidant wound healing branched-chain fatty acids Conidiobolus heterosporus peroxisome proliferator-activated receptor α lipid metabolism fatty acid oxidation hepatocyte n/a thema EDItEUR::N History and Archaeology::NH History thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues Natural-based biomolecules continuously play an important role in novel drug discovery for the treatment of chronic diseases. The development of natural peptide/protein-based, toxin-based, and antibody-based drugs can significantly improve the biomedical efficiency of disease-specific therapy. The focus of this Special Issue of Biomolecules will be on the most recent advances related to novel peptides/proteins, antibodies, and toxins as forms of medicinal therapy. Recent advances in the discovery and development of these natural biomolecules for use in targeted therapy and immunotherapy against chronic diseases (e.g., cancer, diabetes, cardiovascular diseases, and rheumatoid arthritis) will be addressed. The discussion on using novel disease-specific proteins/peptides/toxins/antibodies along with currently available FDA-approved drugs as combinatorial treatments will also be encouraged in this context. Finally, an overview of some of the selected promising natural biomolecules that are potentially able to address the forthcoming challenges in this field will be included. Both research (in particular) and review articles proposing novelties or overviews, respectively, are welcome. 2021-05-01T15:11:51Z 2021-05-01T15:11:51Z 2021 book ONIX_20210501_9783036503868_266 9783036503868 9783036503875 https://directory.doabooks.org/handle/20.500.12854/68520 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/3541 https://mdpi.com/books/pdfview/book/3541 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-0387-5 10.3390/books978-3-0365-0387-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036503868 9783036503875 180 Basel, Switzerland open access |
| spellingShingle | DAPK1 SUMO SENP protein degradation post-translational modification amphibian Bowman-Birk inhibitor Tat peptide molecular cloning antifungal drug design protease inhibitor natural-based compound anticancer therapy lung cancer survivin apoptosis STAT3 colorectal cancer orientin cell cycle arrest Bcl-2 family proteins Astragalus membranaceus insulin PI3K AKT PPARγ PDX-1 Petasites japonicus Asteraceae lignan anti-inflammation NO PGE2 iNOS COX-2 molecular docking peptides kynurenines binding affinity μ-opioid receptor pharmacophore G-protein activation fucoidan PLGA docetaxel drug delivery system anticancer therapy/cancer treatment hIAPP amyloidogenesis insulin granules endoplasmic reticulum anionic lipids F23R variant β-sheet transitions β-cell cytotoxicity unfolded protein response pomegranate punicalagin tannins gingiva fibroblasts antioxidant wound healing branched-chain fatty acids Conidiobolus heterosporus peroxisome proliferator-activated receptor α lipid metabolism fatty acid oxidation hepatocyte n/a thema EDItEUR::N History and Archaeology::NH History thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases |
| title | Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases |
| title_full | Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases |
| title_fullStr | Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases |
| title_full_unstemmed | Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases |
| title_short | Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases |
| title_sort | novel natural based biomolecules discovery for tackling chronic diseases |
| topic | DAPK1 SUMO SENP protein degradation post-translational modification amphibian Bowman-Birk inhibitor Tat peptide molecular cloning antifungal drug design protease inhibitor natural-based compound anticancer therapy lung cancer survivin apoptosis STAT3 colorectal cancer orientin cell cycle arrest Bcl-2 family proteins Astragalus membranaceus insulin PI3K AKT PPARγ PDX-1 Petasites japonicus Asteraceae lignan anti-inflammation NO PGE2 iNOS COX-2 molecular docking peptides kynurenines binding affinity μ-opioid receptor pharmacophore G-protein activation fucoidan PLGA docetaxel drug delivery system anticancer therapy/cancer treatment hIAPP amyloidogenesis insulin granules endoplasmic reticulum anionic lipids F23R variant β-sheet transitions β-cell cytotoxicity unfolded protein response pomegranate punicalagin tannins gingiva fibroblasts antioxidant wound healing branched-chain fatty acids Conidiobolus heterosporus peroxisome proliferator-activated receptor α lipid metabolism fatty acid oxidation hepatocyte n/a thema EDItEUR::N History and Archaeology::NH History thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues |
| topic_facet | DAPK1 SUMO SENP protein degradation post-translational modification amphibian Bowman-Birk inhibitor Tat peptide molecular cloning antifungal drug design protease inhibitor natural-based compound anticancer therapy lung cancer survivin apoptosis STAT3 colorectal cancer orientin cell cycle arrest Bcl-2 family proteins Astragalus membranaceus insulin PI3K AKT PPARγ PDX-1 Petasites japonicus Asteraceae lignan anti-inflammation NO PGE2 iNOS COX-2 molecular docking peptides kynurenines binding affinity μ-opioid receptor pharmacophore G-protein activation fucoidan PLGA docetaxel drug delivery system anticancer therapy/cancer treatment hIAPP amyloidogenesis insulin granules endoplasmic reticulum anionic lipids F23R variant β-sheet transitions β-cell cytotoxicity unfolded protein response pomegranate punicalagin tannins gingiva fibroblasts antioxidant wound healing branched-chain fatty acids Conidiobolus heterosporus peroxisome proliferator-activated receptor α lipid metabolism fatty acid oxidation hepatocyte n/a thema EDItEUR::N History and Archaeology::NH History thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues |
| url | ONIX_20210501_9783036503868_266 |