Refinements to Animal Models for Biomedical Research
There is some talk about an antibiotic Armageddon, wherein untreatable post-operative infections and similarly untreatable complications after chemotherapy will occur. The now famous “O’Neill Report” suggests that, by 2050, more people could die from resistant bacterial infections than from cancer....
Wedi'i Gadw mewn:
| Fformat: | Online |
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| Iaith: | Saesneg |
| Cyhoeddwyd: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Pynciau: | |
| Mynediad Ar-lein: | ONIX_20210501_9783036503325_295 |
| Tagiau: |
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
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| _version_ | 1869527110337429504 |
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| collection | Directory of Open Access Books |
| description | There is some talk about an antibiotic Armageddon, wherein untreatable post-operative infections and similarly untreatable complications after chemotherapy will occur. The now famous “O’Neill Report” suggests that, by 2050, more people could die from resistant bacterial infections than from cancer. We are still learning about all the subtle drivers of antibiotic resistance, realizing that we need a single “whole health” coordinated policy. We ingest what we sometimes feed to animals, yet there does not seem to be any new classes of antibiotics on the horizon. Maybe there is something that has been around forever that could could to our rescue: bacteriophages. Nevertheless, we have to do things differently. We must use antibiotics appropriately and for the correct indication, duration, and dosage with good practice and stewardship.. While by no means comprehensive, this book covers many topics regarding antibiotic stewardship. It also addresses older antibiotics, new combinations, and even new agents. Last but not least, this book features two excellent articles on bacteriophages. Refinements to animal models used in research for either human or animal benefit must be an ongoing aim for anyone working in this context, whether it be as an animal carrier, an animal user, a veterinarian, or an official. Unfortunately, the details of refinements are often overlooked in publications describing the research outcomes. This book includes manuscripts published in the Animals Special Issue “Refinements to Animal Models for Biomedical Research”. In this contemporary resource, we included 12 peer-reviewed papers that cover a range of approaches to the concept of refinement. |
| format | Online |
| id | doab-20.500.12854ir-68549 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-685492024-03-28T03:33:49Z Refinements to Animal Models for Biomedical Research Musk, Gabrielle mouse blood sample well-being retrobulbar submandibular sublingual functional MRI rat anaesthesia refinement calves disbudding gene transcription cytokines pain meloxicam nCounter guinea pig Cavia porcellus captive bolt humane euthanasia laboratory animal humane killing piglet castration behaviour peri-operative vocalisation nociception neonate anaesthesia analgesia sheep survey preclinical research health nociceptive threshold horse cat dog camel 3R principles transdermal fentanyl patch grimace scores laboratory animals pain assessment rabbit postoperative analgesia facial expressions grimace scales mice rat animal research animal testing biomedical research history of science n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences There is some talk about an antibiotic Armageddon, wherein untreatable post-operative infections and similarly untreatable complications after chemotherapy will occur. The now famous “O’Neill Report” suggests that, by 2050, more people could die from resistant bacterial infections than from cancer. We are still learning about all the subtle drivers of antibiotic resistance, realizing that we need a single “whole health” coordinated policy. We ingest what we sometimes feed to animals, yet there does not seem to be any new classes of antibiotics on the horizon. Maybe there is something that has been around forever that could could to our rescue: bacteriophages. Nevertheless, we have to do things differently. We must use antibiotics appropriately and for the correct indication, duration, and dosage with good practice and stewardship.. While by no means comprehensive, this book covers many topics regarding antibiotic stewardship. It also addresses older antibiotics, new combinations, and even new agents. Last but not least, this book features two excellent articles on bacteriophages. Refinements to animal models used in research for either human or animal benefit must be an ongoing aim for anyone working in this context, whether it be as an animal carrier, an animal user, a veterinarian, or an official. Unfortunately, the details of refinements are often overlooked in publications describing the research outcomes. This book includes manuscripts published in the Animals Special Issue “Refinements to Animal Models for Biomedical Research”. In this contemporary resource, we included 12 peer-reviewed papers that cover a range of approaches to the concept of refinement. 2021-05-01T15:12:26Z 2021-05-01T15:12:26Z 2021 book ONIX_20210501_9783036503325_295 9783036503325 9783036503332 https://directory.doabooks.org/handle/20.500.12854/68549 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/3570 https://mdpi.com/books/pdfview/book/3570 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-0333-2 10.3390/books978-3-0365-0333-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036503325 9783036503332 234 Basel, Switzerland open access |
| spellingShingle | mouse blood sample well-being retrobulbar submandibular sublingual functional MRI rat anaesthesia refinement calves disbudding gene transcription cytokines pain meloxicam nCounter guinea pig Cavia porcellus captive bolt humane euthanasia laboratory animal humane killing piglet castration behaviour peri-operative vocalisation nociception neonate anaesthesia analgesia sheep survey preclinical research health nociceptive threshold horse cat dog camel 3R principles transdermal fentanyl patch grimace scores laboratory animals pain assessment rabbit postoperative analgesia facial expressions grimace scales mice rat animal research animal testing biomedical research history of science n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Refinements to Animal Models for Biomedical Research |
| title | Refinements to Animal Models for Biomedical Research |
| title_full | Refinements to Animal Models for Biomedical Research |
| title_fullStr | Refinements to Animal Models for Biomedical Research |
| title_full_unstemmed | Refinements to Animal Models for Biomedical Research |
| title_short | Refinements to Animal Models for Biomedical Research |
| title_sort | refinements to animal models for biomedical research |
| topic | mouse blood sample well-being retrobulbar submandibular sublingual functional MRI rat anaesthesia refinement calves disbudding gene transcription cytokines pain meloxicam nCounter guinea pig Cavia porcellus captive bolt humane euthanasia laboratory animal humane killing piglet castration behaviour peri-operative vocalisation nociception neonate anaesthesia analgesia sheep survey preclinical research health nociceptive threshold horse cat dog camel 3R principles transdermal fentanyl patch grimace scores laboratory animals pain assessment rabbit postoperative analgesia facial expressions grimace scales mice rat animal research animal testing biomedical research history of science n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | mouse blood sample well-being retrobulbar submandibular sublingual functional MRI rat anaesthesia refinement calves disbudding gene transcription cytokines pain meloxicam nCounter guinea pig Cavia porcellus captive bolt humane euthanasia laboratory animal humane killing piglet castration behaviour peri-operative vocalisation nociception neonate anaesthesia analgesia sheep survey preclinical research health nociceptive threshold horse cat dog camel 3R principles transdermal fentanyl patch grimace scores laboratory animals pain assessment rabbit postoperative analgesia facial expressions grimace scales mice rat animal research animal testing biomedical research history of science n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20210501_9783036503325_295 |