Bioinorganic Chemistry of Nickel
The chemistry of nickel in biological systems has been intensely investigated since the discovery of the essential role played by this transition metal in the enzyme urease, ca. 1975. Since then, several nickel-dependent enzymes have been discovered and characterized at the molecular level using str...
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| Formato: | Online |
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| Lenguaje: | inglés |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Acceso en línea: | ONIX_20210501_9783039280667_362 |
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| collection | Directory of Open Access Books |
| description | The chemistry of nickel in biological systems has been intensely investigated since the discovery of the essential role played by this transition metal in the enzyme urease, ca. 1975. Since then, several nickel-dependent enzymes have been discovered and characterized at the molecular level using structural, spectroscopic, and kinetic methods, and insight into reaction mechanisms has been elaborated using synthetic and computational models. The dual role of nickel as both an essential nutrient and as a toxin has prompted efforts to understand the molecular mechanisms of nickel toxicology and to uncover the means by which cells select nickel from among a pool of different and more readily available metal ions and thus regulate the intracellular chemistry of nickel. This latter effort highlights the importance of proteins involved in the extra- and intra-cellular sensing of nickel, the roles of nickel-selective proteins for import and export, and nickel-responsive transcription factors, all of which are important for regulating nickel homeostasis. In this Special Issue, the contributing authors have covered recent advances in many of these aspects of nickel biochemistry, including toxicology, bacterial pathogenesis, carcinogenesis, computational and synthetic models, nickel trafficking proteins, and enzymology. |
| format | Online |
| id | doab-20.500.12854ir-68616 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-686162024-03-27T16:34:31Z Bioinorganic Chemistry of Nickel Maroney, Michael J. Ciurli, Stefano InrS nickel-dependent transcriptional regulators molecular modelling nickel hydrogenase urease Ni-enzymes pathogens ncRNA miRNA lncRNA lung carcinogenesis histidine-rich protein carbon monoxide dehydrogenase nickel chaperone nickel-induced oligomerization urease maturation metallochaperone G-protein conformational change bioavailability carcinogenicity genotoxicity allergy reproductive asthma nanoparticles ecotoxicity environment biological nickel sites nickel-thiolates dinuclear nickel metallopeptides thiolate oxidative damage nickel enzymes reaction mechanism quantum chemical calculations glyoxalase streptomyces mycothiol metalloenzyme AD11 nickel-dependent enzyme methionine salvage pathway methionine S-adenosylmethionine (SAM) methylthioadenosine (MTA) enolase phosphatase 1 (ENOPH1) polyamine matrix metalloproteinase MT1 (MT1-MMP) metalloregulator chaperone [NiFe]-hydrogenase n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general The chemistry of nickel in biological systems has been intensely investigated since the discovery of the essential role played by this transition metal in the enzyme urease, ca. 1975. Since then, several nickel-dependent enzymes have been discovered and characterized at the molecular level using structural, spectroscopic, and kinetic methods, and insight into reaction mechanisms has been elaborated using synthetic and computational models. The dual role of nickel as both an essential nutrient and as a toxin has prompted efforts to understand the molecular mechanisms of nickel toxicology and to uncover the means by which cells select nickel from among a pool of different and more readily available metal ions and thus regulate the intracellular chemistry of nickel. This latter effort highlights the importance of proteins involved in the extra- and intra-cellular sensing of nickel, the roles of nickel-selective proteins for import and export, and nickel-responsive transcription factors, all of which are important for regulating nickel homeostasis. In this Special Issue, the contributing authors have covered recent advances in many of these aspects of nickel biochemistry, including toxicology, bacterial pathogenesis, carcinogenesis, computational and synthetic models, nickel trafficking proteins, and enzymology. 2021-05-01T15:15:54Z 2021-05-01T15:15:54Z 2020 book ONIX_20210501_9783039280667_362 9783039280667 9783039280674 https://directory.doabooks.org/handle/20.500.12854/68616 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/2378 https://mdpi.com/books/pdfview/book/2378 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-067-4 10.3390/books978-3-03928-067-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039280667 9783039280674 238 Basel, Switzerland open access |
| spellingShingle | InrS nickel-dependent transcriptional regulators molecular modelling nickel hydrogenase urease Ni-enzymes pathogens ncRNA miRNA lncRNA lung carcinogenesis histidine-rich protein carbon monoxide dehydrogenase nickel chaperone nickel-induced oligomerization urease maturation metallochaperone G-protein conformational change bioavailability carcinogenicity genotoxicity allergy reproductive asthma nanoparticles ecotoxicity environment biological nickel sites nickel-thiolates dinuclear nickel metallopeptides thiolate oxidative damage nickel enzymes reaction mechanism quantum chemical calculations glyoxalase streptomyces mycothiol metalloenzyme AD11 nickel-dependent enzyme methionine salvage pathway methionine S-adenosylmethionine (SAM) methylthioadenosine (MTA) enolase phosphatase 1 (ENOPH1) polyamine matrix metalloproteinase MT1 (MT1-MMP) metalloregulator chaperone [NiFe]-hydrogenase n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general Bioinorganic Chemistry of Nickel |
| title | Bioinorganic Chemistry of Nickel |
| title_full | Bioinorganic Chemistry of Nickel |
| title_fullStr | Bioinorganic Chemistry of Nickel |
| title_full_unstemmed | Bioinorganic Chemistry of Nickel |
| title_short | Bioinorganic Chemistry of Nickel |
| title_sort | bioinorganic chemistry of nickel |
| topic | InrS nickel-dependent transcriptional regulators molecular modelling nickel hydrogenase urease Ni-enzymes pathogens ncRNA miRNA lncRNA lung carcinogenesis histidine-rich protein carbon monoxide dehydrogenase nickel chaperone nickel-induced oligomerization urease maturation metallochaperone G-protein conformational change bioavailability carcinogenicity genotoxicity allergy reproductive asthma nanoparticles ecotoxicity environment biological nickel sites nickel-thiolates dinuclear nickel metallopeptides thiolate oxidative damage nickel enzymes reaction mechanism quantum chemical calculations glyoxalase streptomyces mycothiol metalloenzyme AD11 nickel-dependent enzyme methionine salvage pathway methionine S-adenosylmethionine (SAM) methylthioadenosine (MTA) enolase phosphatase 1 (ENOPH1) polyamine matrix metalloproteinase MT1 (MT1-MMP) metalloregulator chaperone [NiFe]-hydrogenase n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general |
| topic_facet | InrS nickel-dependent transcriptional regulators molecular modelling nickel hydrogenase urease Ni-enzymes pathogens ncRNA miRNA lncRNA lung carcinogenesis histidine-rich protein carbon monoxide dehydrogenase nickel chaperone nickel-induced oligomerization urease maturation metallochaperone G-protein conformational change bioavailability carcinogenicity genotoxicity allergy reproductive asthma nanoparticles ecotoxicity environment biological nickel sites nickel-thiolates dinuclear nickel metallopeptides thiolate oxidative damage nickel enzymes reaction mechanism quantum chemical calculations glyoxalase streptomyces mycothiol metalloenzyme AD11 nickel-dependent enzyme methionine salvage pathway methionine S-adenosylmethionine (SAM) methylthioadenosine (MTA) enolase phosphatase 1 (ENOPH1) polyamine matrix metalloproteinase MT1 (MT1-MMP) metalloregulator chaperone [NiFe]-hydrogenase n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general |
| url | ONIX_20210501_9783039280667_362 |