Human African Trypanosomiasis (Sleeping Sickness)
As it is a goal to eliminate human African trypanosomiasis (HAT; sleeping sickness) as a public health problem by 2020 and interrupt transmission by 2030, this is a good moment to reflect on what we have achieved, what we want to achieve, and what could get in our way. HAT has a reputation for spect...
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| Formaat: | Online |
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| Taal: | Engels |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Online toegang: | ONIX_20210501_9783039289639_370 |
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| collection | Directory of Open Access Books |
| description | As it is a goal to eliminate human African trypanosomiasis (HAT; sleeping sickness) as a public health problem by 2020 and interrupt transmission by 2030, this is a good moment to reflect on what we have achieved, what we want to achieve, and what could get in our way. HAT has a reputation for spectacular reappearances, and the latest peak of 40,000 reported and over 300,000 estimated cases only dates back to 1998. Efforts of the WHO and partners as well as the development of simpler and much better-tolerated treatments, improved diagnostics, and vector control tools made it possible to reduce this number by 95%. Case identification and confirmation remain complex and require specific skills, treatment remains error-prone and reports on long-term survivors have emerged, and the relevance of the animal reservoir for T. b. gambiense HAT needs clarification. In addition, to win the “end game” against this massively stigmatized disease, the human factor will play a key role. This Special Issue addresses many of the burning topics about disease elimination in its 12 research and 7 review articles and one case study. The papers critically reflect the approaches used, investigate the mentioned challenges, and propose novel approaches and interventions from various points of view. |
| format | Online |
| id | doab-20.500.12854ir-68624 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-686242024-03-31T13:10:30Z Human African Trypanosomiasis (Sleeping Sickness) Burri, Christian (+)-spectaline iso-6-spectaline Trypanosoma brucei rhodesiense autophagy apoptosis cross-talk trypanosomosis iron transferrin transferrin receptor nutritional immunity flagellar pocket Human African Trypanosomiasis (HAT) mydriasis neurological signs eradication re-emergence human African trypanosomiasis treatment melarsoprol adverse event encephalopathy human leukocyte antigen association study disease elimination disease eradication frontline workers DR Congo mobile screening qualitative methods sequelae serology oligosymptomatic HAT product development partnerships research and development medical innovation donor policy African trypanosomiasis sleeping sickness trypanosoma brucei drugs drug resistance history human Africa trypanosomiasis fexinidazole home-based treatment patient-centred care Uganda elimination T. b. gambiense g-HAT T. b. rhodesiense r-HAT neglected tropical diseases Trypanosoma brucei drug discovery high-throughput screening blood–brain barrier brain permeability pharmacology phenotypic drug screening Haemoparasites animal reservoirs Trypanosoma growth inhibitors chemotherapy pafuramidine acoziborole African sleeping sickness development of treatment suramin medical history political history clinical research health system strengthening South Sudan diagnosis symptoms treatment-seeking case detection embodiment expertise serendipity CATT positive serological suspects active follow-up strategy n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNS Epidemiology and Medical statistics As it is a goal to eliminate human African trypanosomiasis (HAT; sleeping sickness) as a public health problem by 2020 and interrupt transmission by 2030, this is a good moment to reflect on what we have achieved, what we want to achieve, and what could get in our way. HAT has a reputation for spectacular reappearances, and the latest peak of 40,000 reported and over 300,000 estimated cases only dates back to 1998. Efforts of the WHO and partners as well as the development of simpler and much better-tolerated treatments, improved diagnostics, and vector control tools made it possible to reduce this number by 95%. Case identification and confirmation remain complex and require specific skills, treatment remains error-prone and reports on long-term survivors have emerged, and the relevance of the animal reservoir for T. b. gambiense HAT needs clarification. In addition, to win the “end game” against this massively stigmatized disease, the human factor will play a key role. This Special Issue addresses many of the burning topics about disease elimination in its 12 research and 7 review articles and one case study. The papers critically reflect the approaches used, investigate the mentioned challenges, and propose novel approaches and interventions from various points of view. 2021-05-01T15:16:04Z 2021-05-01T15:16:04Z 2020 book ONIX_20210501_9783039289639_370 9783039289639 9783039289646 https://directory.doabooks.org/handle/20.500.12854/68624 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/2386 https://mdpi.com/books/pdfview/book/2386 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-964-6 10.3390/books978-3-03928-964-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039289639 9783039289646 280 Basel, Switzerland open access |
| spellingShingle | (+)-spectaline iso-6-spectaline Trypanosoma brucei rhodesiense autophagy apoptosis cross-talk trypanosomosis iron transferrin transferrin receptor nutritional immunity flagellar pocket Human African Trypanosomiasis (HAT) mydriasis neurological signs eradication re-emergence human African trypanosomiasis treatment melarsoprol adverse event encephalopathy human leukocyte antigen association study disease elimination disease eradication frontline workers DR Congo mobile screening qualitative methods sequelae serology oligosymptomatic HAT product development partnerships research and development medical innovation donor policy African trypanosomiasis sleeping sickness trypanosoma brucei drugs drug resistance history human Africa trypanosomiasis fexinidazole home-based treatment patient-centred care Uganda elimination T. b. gambiense g-HAT T. b. rhodesiense r-HAT neglected tropical diseases Trypanosoma brucei drug discovery high-throughput screening blood–brain barrier brain permeability pharmacology phenotypic drug screening Haemoparasites animal reservoirs Trypanosoma growth inhibitors chemotherapy pafuramidine acoziborole African sleeping sickness development of treatment suramin medical history political history clinical research health system strengthening South Sudan diagnosis symptoms treatment-seeking case detection embodiment expertise serendipity CATT positive serological suspects active follow-up strategy n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNS Epidemiology and Medical statistics Human African Trypanosomiasis (Sleeping Sickness) |
| title | Human African Trypanosomiasis (Sleeping Sickness) |
| title_full | Human African Trypanosomiasis (Sleeping Sickness) |
| title_fullStr | Human African Trypanosomiasis (Sleeping Sickness) |
| title_full_unstemmed | Human African Trypanosomiasis (Sleeping Sickness) |
| title_short | Human African Trypanosomiasis (Sleeping Sickness) |
| title_sort | human african trypanosomiasis sleeping sickness |
| topic | (+)-spectaline iso-6-spectaline Trypanosoma brucei rhodesiense autophagy apoptosis cross-talk trypanosomosis iron transferrin transferrin receptor nutritional immunity flagellar pocket Human African Trypanosomiasis (HAT) mydriasis neurological signs eradication re-emergence human African trypanosomiasis treatment melarsoprol adverse event encephalopathy human leukocyte antigen association study disease elimination disease eradication frontline workers DR Congo mobile screening qualitative methods sequelae serology oligosymptomatic HAT product development partnerships research and development medical innovation donor policy African trypanosomiasis sleeping sickness trypanosoma brucei drugs drug resistance history human Africa trypanosomiasis fexinidazole home-based treatment patient-centred care Uganda elimination T. b. gambiense g-HAT T. b. rhodesiense r-HAT neglected tropical diseases Trypanosoma brucei drug discovery high-throughput screening blood–brain barrier brain permeability pharmacology phenotypic drug screening Haemoparasites animal reservoirs Trypanosoma growth inhibitors chemotherapy pafuramidine acoziborole African sleeping sickness development of treatment suramin medical history political history clinical research health system strengthening South Sudan diagnosis symptoms treatment-seeking case detection embodiment expertise serendipity CATT positive serological suspects active follow-up strategy n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNS Epidemiology and Medical statistics |
| topic_facet | (+)-spectaline iso-6-spectaline Trypanosoma brucei rhodesiense autophagy apoptosis cross-talk trypanosomosis iron transferrin transferrin receptor nutritional immunity flagellar pocket Human African Trypanosomiasis (HAT) mydriasis neurological signs eradication re-emergence human African trypanosomiasis treatment melarsoprol adverse event encephalopathy human leukocyte antigen association study disease elimination disease eradication frontline workers DR Congo mobile screening qualitative methods sequelae serology oligosymptomatic HAT product development partnerships research and development medical innovation donor policy African trypanosomiasis sleeping sickness trypanosoma brucei drugs drug resistance history human Africa trypanosomiasis fexinidazole home-based treatment patient-centred care Uganda elimination T. b. gambiense g-HAT T. b. rhodesiense r-HAT neglected tropical diseases Trypanosoma brucei drug discovery high-throughput screening blood–brain barrier brain permeability pharmacology phenotypic drug screening Haemoparasites animal reservoirs Trypanosoma growth inhibitors chemotherapy pafuramidine acoziborole African sleeping sickness development of treatment suramin medical history political history clinical research health system strengthening South Sudan diagnosis symptoms treatment-seeking case detection embodiment expertise serendipity CATT positive serological suspects active follow-up strategy n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNS Epidemiology and Medical statistics |
| url | ONIX_20210501_9783039289639_370 |