Natural Products and Neuroprotection
Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are the most common pathologies of the central nervous system currently without a cure. They share common molecular and cellular characteristics, including protein misfolding, mitochondri...
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| Natura: | Online |
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| Lingua: | inglese |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Soggetti: | |
| Accesso online: | ONIX_20210501_9783039362165_385 |
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| _version_ | 1869525943180066816 |
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| collection | Directory of Open Access Books |
| description | Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are the most common pathologies of the central nervous system currently without a cure. They share common molecular and cellular characteristics, including protein misfolding, mitochondrial dysfunction, glutamate toxicity, dysregulation of calcium homeostasis, oxidative stress, inflammation, and ageing, which contribute to neuronal death. Efforts to treat these diseases are often limited by their multifactorial etiology. Natural products, thanks to their multitarget activities, are considered promising alternatives for the treatment of neurodegeneration. This book deals with two different forms of natural products: extracts and isolated compounds. The study of the bioactivity of the extracts is extremely important as many studies have demonstrated the synergistic effect of the combination of different natural products. On the other hand, the investigation of the activity of specifically isolated natural products can be also important to understand their cellular and molecular mechanisms and to define the specific bioactive components in extracts or foods. This book can be considered an important contribution to knowledge of the neuroprotective effect of natural products and presents a great deal of information, related to both the benefits but also the limitations of their use in counteracting neurodegeneration. |
| format | Online |
| id | doab-20.500.12854ir-68639 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-686392024-03-28T03:33:45Z Natural Products and Neuroprotection Angeloni, Cristina Vauzour, David Vitamin D Multiple Sclerosis symptom neurodegeneration oxidative injury Parkinson’s disease terpenes, rotenone thymol Alzheimer’s disease Centella asiatica hippocampus protein poshophatase 2 glycogen synthase kinase 3 B-cell lymphoma 2 neuroprotection nutraceuticals bioavailability stress response neurodegenerative disease bioactive compound natural extract β-amyloid peptide tau protein clinical trial human studies animal studies in vitro studies curcumin free radicals heme oxygenase safety profile type 2 diabetes inflammation vascular damage learning memory natural compound oxidative stress cognitive dysfunction cell death synapse loss protein aggregation neuroinflammation algae seaweeds neurodegenerative diseases auraptene dopamine neuron antioxidant mitochondria Chionanthus retusus flavonoid flower HO-1 NO Lippia citriodora VEE Vs relaxation depression cyclic AMP calcium blood–brain barrier catechin cognition epigallocatechin gallate green tea microbiota 5-(3,5-dihydroxyphenyl)-γ-valerolactone ascaroside pheromone C. elegans dauer neuronal signaling sexual behavior survival signals proteostasis chaperones autophagy ubiquitin-proteasome unfolded protein response natural compounds natural products ethics patients’ autonomy beneficence nonmaleficence medical liability Parkinson’s disease (PD) mitochondrial dysfunction dynamics hormesis ubiquitin‒proteasome system (UPS) mitophagy n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are the most common pathologies of the central nervous system currently without a cure. They share common molecular and cellular characteristics, including protein misfolding, mitochondrial dysfunction, glutamate toxicity, dysregulation of calcium homeostasis, oxidative stress, inflammation, and ageing, which contribute to neuronal death. Efforts to treat these diseases are often limited by their multifactorial etiology. Natural products, thanks to their multitarget activities, are considered promising alternatives for the treatment of neurodegeneration. This book deals with two different forms of natural products: extracts and isolated compounds. The study of the bioactivity of the extracts is extremely important as many studies have demonstrated the synergistic effect of the combination of different natural products. On the other hand, the investigation of the activity of specifically isolated natural products can be also important to understand their cellular and molecular mechanisms and to define the specific bioactive components in extracts or foods. This book can be considered an important contribution to knowledge of the neuroprotective effect of natural products and presents a great deal of information, related to both the benefits but also the limitations of their use in counteracting neurodegeneration. 2021-05-01T15:16:23Z 2021-05-01T15:16:23Z 2020 book ONIX_20210501_9783039362165_385 9783039362165 9783039362172 https://directory.doabooks.org/handle/20.500.12854/68639 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/2401 https://mdpi.com/books/pdfview/book/2401 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03936-217-2 10.3390/books978-3-03936-217-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039362165 9783039362172 338 Basel, Switzerland open access |
| spellingShingle | Vitamin D Multiple Sclerosis symptom neurodegeneration oxidative injury Parkinson’s disease terpenes, rotenone thymol Alzheimer’s disease Centella asiatica hippocampus protein poshophatase 2 glycogen synthase kinase 3 B-cell lymphoma 2 neuroprotection nutraceuticals bioavailability stress response neurodegenerative disease bioactive compound natural extract β-amyloid peptide tau protein clinical trial human studies animal studies in vitro studies curcumin free radicals heme oxygenase safety profile type 2 diabetes inflammation vascular damage learning memory natural compound oxidative stress cognitive dysfunction cell death synapse loss protein aggregation neuroinflammation algae seaweeds neurodegenerative diseases auraptene dopamine neuron antioxidant mitochondria Chionanthus retusus flavonoid flower HO-1 NO Lippia citriodora VEE Vs relaxation depression cyclic AMP calcium blood–brain barrier catechin cognition epigallocatechin gallate green tea microbiota 5-(3,5-dihydroxyphenyl)-γ-valerolactone ascaroside pheromone C. elegans dauer neuronal signaling sexual behavior survival signals proteostasis chaperones autophagy ubiquitin-proteasome unfolded protein response natural compounds natural products ethics patients’ autonomy beneficence nonmaleficence medical liability Parkinson’s disease (PD) mitochondrial dysfunction dynamics hormesis ubiquitin‒proteasome system (UPS) mitophagy n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Natural Products and Neuroprotection |
| title | Natural Products and Neuroprotection |
| title_full | Natural Products and Neuroprotection |
| title_fullStr | Natural Products and Neuroprotection |
| title_full_unstemmed | Natural Products and Neuroprotection |
| title_short | Natural Products and Neuroprotection |
| title_sort | natural products and neuroprotection |
| topic | Vitamin D Multiple Sclerosis symptom neurodegeneration oxidative injury Parkinson’s disease terpenes, rotenone thymol Alzheimer’s disease Centella asiatica hippocampus protein poshophatase 2 glycogen synthase kinase 3 B-cell lymphoma 2 neuroprotection nutraceuticals bioavailability stress response neurodegenerative disease bioactive compound natural extract β-amyloid peptide tau protein clinical trial human studies animal studies in vitro studies curcumin free radicals heme oxygenase safety profile type 2 diabetes inflammation vascular damage learning memory natural compound oxidative stress cognitive dysfunction cell death synapse loss protein aggregation neuroinflammation algae seaweeds neurodegenerative diseases auraptene dopamine neuron antioxidant mitochondria Chionanthus retusus flavonoid flower HO-1 NO Lippia citriodora VEE Vs relaxation depression cyclic AMP calcium blood–brain barrier catechin cognition epigallocatechin gallate green tea microbiota 5-(3,5-dihydroxyphenyl)-γ-valerolactone ascaroside pheromone C. elegans dauer neuronal signaling sexual behavior survival signals proteostasis chaperones autophagy ubiquitin-proteasome unfolded protein response natural compounds natural products ethics patients’ autonomy beneficence nonmaleficence medical liability Parkinson’s disease (PD) mitochondrial dysfunction dynamics hormesis ubiquitin‒proteasome system (UPS) mitophagy n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Vitamin D Multiple Sclerosis symptom neurodegeneration oxidative injury Parkinson’s disease terpenes, rotenone thymol Alzheimer’s disease Centella asiatica hippocampus protein poshophatase 2 glycogen synthase kinase 3 B-cell lymphoma 2 neuroprotection nutraceuticals bioavailability stress response neurodegenerative disease bioactive compound natural extract β-amyloid peptide tau protein clinical trial human studies animal studies in vitro studies curcumin free radicals heme oxygenase safety profile type 2 diabetes inflammation vascular damage learning memory natural compound oxidative stress cognitive dysfunction cell death synapse loss protein aggregation neuroinflammation algae seaweeds neurodegenerative diseases auraptene dopamine neuron antioxidant mitochondria Chionanthus retusus flavonoid flower HO-1 NO Lippia citriodora VEE Vs relaxation depression cyclic AMP calcium blood–brain barrier catechin cognition epigallocatechin gallate green tea microbiota 5-(3,5-dihydroxyphenyl)-γ-valerolactone ascaroside pheromone C. elegans dauer neuronal signaling sexual behavior survival signals proteostasis chaperones autophagy ubiquitin-proteasome unfolded protein response natural compounds natural products ethics patients’ autonomy beneficence nonmaleficence medical liability Parkinson’s disease (PD) mitochondrial dysfunction dynamics hormesis ubiquitin‒proteasome system (UPS) mitophagy n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20210501_9783039362165_385 |