Free Radical Research in Cancer
Cancer is a great challenge to efficient therapy due to biological diversity. Disturbed oxidative homeostasis in cancer cells certainly contributes to differential therapy response. Further, one of the hallmarks of cancer cells is adaptation which includes fine tuning of the cellular metabolic and s...
I tiakina i:
| Hōputu: | Online |
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| Reo: | Ingarihi |
| I whakaputaina: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Ngā marau: | |
| Urunga tuihono: | ONIX_20210501_9783039360888_390 |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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| _version_ | 1869527123437289472 |
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| collection | Directory of Open Access Books |
| description | Cancer is a great challenge to efficient therapy due to biological diversity. Disturbed oxidative homeostasis in cancer cells certainly contributes to differential therapy response. Further, one of the hallmarks of cancer cells is adaptation which includes fine tuning of the cellular metabolic and signalling pathways as well as transcription profiles. There are several factors which contribute to the tumor diversity and therapy response, and oxidative stress is certainly one of them. Changes in oxygen levels due to hypoxia/reoxygenation during tumor growth modulate antioxidative patterns finally supporting increased cell diversity and adaptation to stressing conditions. Additionally, cancer chemotherapy based on ROS production can also induce also adaptation. To counteract these negative effects natural products are often used for their antioxidant activities as well as photodynamic therapy supported by novel chemosensitizers. Understanding of possible pathways which can trigger antioxidant defence at a certain time during cancer development can also provide possible strategies in fighting cancer. |
| format | Online |
| id | doab-20.500.12854ir-68644 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-686442024-04-09T23:15:37Z Free Radical Research in Cancer Čipak Gašparović, Ana NQO1 NQO1*2 polymorphism quinone breast cancer menadione lapachone doxorubicin ascorbate oxidative stress reactive oxygen species sperm cancer chemotherapy antioxidant therapy antioxidant proteins chemoresistance oxaliplatin 5-Fluorouracil myelodysplastic syndromes carbonylation deferasirox ovary calcium channel Trolox granulosa cell tumor cell death mitochondria photodynamic therapy singlet oxygen nitric oxide light combination therapy antioxidants bleomycin cancer treatment chemotherapy-induced toxicity cisplatin free radicals methotrexate ozone therapy lung cancer cancer metabolism reactive oxygen species (ROS) therapy resistance new therapeutic strategies breast cancer stem cells 4-hydroxy-2-nonenal extracellular matrix NRF2 bardoxolone methyl prostate cancer castration-resistant prostate cancer androgen receptor (AR), AR-V7 anti-androgen enzalutamide androgen deprivation therapy cancer antioxidant triphala ayurveda chemoprevention and chemotherapy n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues Cancer is a great challenge to efficient therapy due to biological diversity. Disturbed oxidative homeostasis in cancer cells certainly contributes to differential therapy response. Further, one of the hallmarks of cancer cells is adaptation which includes fine tuning of the cellular metabolic and signalling pathways as well as transcription profiles. There are several factors which contribute to the tumor diversity and therapy response, and oxidative stress is certainly one of them. Changes in oxygen levels due to hypoxia/reoxygenation during tumor growth modulate antioxidative patterns finally supporting increased cell diversity and adaptation to stressing conditions. Additionally, cancer chemotherapy based on ROS production can also induce also adaptation. To counteract these negative effects natural products are often used for their antioxidant activities as well as photodynamic therapy supported by novel chemosensitizers. Understanding of possible pathways which can trigger antioxidant defence at a certain time during cancer development can also provide possible strategies in fighting cancer. 2021-05-01T15:16:33Z 2021-05-01T15:16:33Z 2020 book ONIX_20210501_9783039360888_390 9783039360888 9783039360895 https://directory.doabooks.org/handle/20.500.12854/68644 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/2406 https://mdpi.com/books/pdfview/book/2406 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03936-089-5 10.3390/books978-3-03936-089-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039360888 9783039360895 192 Basel, Switzerland open access |
| spellingShingle | NQO1 NQO1*2 polymorphism quinone breast cancer menadione lapachone doxorubicin ascorbate oxidative stress reactive oxygen species sperm cancer chemotherapy antioxidant therapy antioxidant proteins chemoresistance oxaliplatin 5-Fluorouracil myelodysplastic syndromes carbonylation deferasirox ovary calcium channel Trolox granulosa cell tumor cell death mitochondria photodynamic therapy singlet oxygen nitric oxide light combination therapy antioxidants bleomycin cancer treatment chemotherapy-induced toxicity cisplatin free radicals methotrexate ozone therapy lung cancer cancer metabolism reactive oxygen species (ROS) therapy resistance new therapeutic strategies breast cancer stem cells 4-hydroxy-2-nonenal extracellular matrix NRF2 bardoxolone methyl prostate cancer castration-resistant prostate cancer androgen receptor (AR), AR-V7 anti-androgen enzalutamide androgen deprivation therapy cancer antioxidant triphala ayurveda chemoprevention and chemotherapy n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues Free Radical Research in Cancer |
| title | Free Radical Research in Cancer |
| title_full | Free Radical Research in Cancer |
| title_fullStr | Free Radical Research in Cancer |
| title_full_unstemmed | Free Radical Research in Cancer |
| title_short | Free Radical Research in Cancer |
| title_sort | free radical research in cancer |
| topic | NQO1 NQO1*2 polymorphism quinone breast cancer menadione lapachone doxorubicin ascorbate oxidative stress reactive oxygen species sperm cancer chemotherapy antioxidant therapy antioxidant proteins chemoresistance oxaliplatin 5-Fluorouracil myelodysplastic syndromes carbonylation deferasirox ovary calcium channel Trolox granulosa cell tumor cell death mitochondria photodynamic therapy singlet oxygen nitric oxide light combination therapy antioxidants bleomycin cancer treatment chemotherapy-induced toxicity cisplatin free radicals methotrexate ozone therapy lung cancer cancer metabolism reactive oxygen species (ROS) therapy resistance new therapeutic strategies breast cancer stem cells 4-hydroxy-2-nonenal extracellular matrix NRF2 bardoxolone methyl prostate cancer castration-resistant prostate cancer androgen receptor (AR), AR-V7 anti-androgen enzalutamide androgen deprivation therapy cancer antioxidant triphala ayurveda chemoprevention and chemotherapy n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues |
| topic_facet | NQO1 NQO1*2 polymorphism quinone breast cancer menadione lapachone doxorubicin ascorbate oxidative stress reactive oxygen species sperm cancer chemotherapy antioxidant therapy antioxidant proteins chemoresistance oxaliplatin 5-Fluorouracil myelodysplastic syndromes carbonylation deferasirox ovary calcium channel Trolox granulosa cell tumor cell death mitochondria photodynamic therapy singlet oxygen nitric oxide light combination therapy antioxidants bleomycin cancer treatment chemotherapy-induced toxicity cisplatin free radicals methotrexate ozone therapy lung cancer cancer metabolism reactive oxygen species (ROS) therapy resistance new therapeutic strategies breast cancer stem cells 4-hydroxy-2-nonenal extracellular matrix NRF2 bardoxolone methyl prostate cancer castration-resistant prostate cancer androgen receptor (AR), AR-V7 anti-androgen enzalutamide androgen deprivation therapy cancer antioxidant triphala ayurveda chemoprevention and chemotherapy n/a thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues |
| url | ONIX_20210501_9783039360888_390 |