Ricin Toxins
The plant toxin ricin is one of the most potent and lethal substances known. Due to its wide availability and the ease of production, ricin has been exploited as an agent of bioterrorism and biological warfare and is classified as a level B threat. Tons of ricin are produced annually worldwide as a...
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| Formaat: | Online |
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| Taal: | Engels |
| Gepubliceerd in: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Online toegang: | ONIX_20210501_9783039285129_582 |
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| _version_ | 1869517932648726528 |
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| collection | Directory of Open Access Books |
| description | The plant toxin ricin is one of the most potent and lethal substances known. Due to its wide availability and the ease of production, ricin has been exploited as an agent of bioterrorism and biological warfare and is classified as a level B threat. Tons of ricin are produced annually worldwide as a by-product of castor oil, leading to exposure. Currently, there is no proven safe treatment for ricin intoxication. Ricin consists of an active A subunit (RTA) covalently linked to a cell binding B subunit (RTB). RTA depurinates a universally conserved adenine in the sarcin–ricin loop (SRL) of the large rRNA and inhibits protein synthesis. RTA-antibody complexes have been explored as immunotoxins against cancer cells. The articles published in this book address the history of ricin research, how ricin enters cells and traffics to the ribosome, how it inactivates ribosomes, how it induces inflammatory signaling pathways and programmed cell death, the design of therapies against ricin intoxication, and innovative assays for ricin detection. |
| format | Online |
| id | doab-20.500.12854ir-68836 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-688362024-03-30T23:22:13Z Ricin Toxins Tumer, Nilgun E. thema EDItEUR::M Medicine and Nursing The plant toxin ricin is one of the most potent and lethal substances known. Due to its wide availability and the ease of production, ricin has been exploited as an agent of bioterrorism and biological warfare and is classified as a level B threat. Tons of ricin are produced annually worldwide as a by-product of castor oil, leading to exposure. Currently, there is no proven safe treatment for ricin intoxication. Ricin consists of an active A subunit (RTA) covalently linked to a cell binding B subunit (RTB). RTA depurinates a universally conserved adenine in the sarcin–ricin loop (SRL) of the large rRNA and inhibits protein synthesis. RTA-antibody complexes have been explored as immunotoxins against cancer cells. The articles published in this book address the history of ricin research, how ricin enters cells and traffics to the ribosome, how it inactivates ribosomes, how it induces inflammatory signaling pathways and programmed cell death, the design of therapies against ricin intoxication, and innovative assays for ricin detection. 2021-05-01T15:30:23Z 2021-05-01T15:30:23Z 2020 book ONIX_20210501_9783039285129_582 9783039285129 9783039285136 https://directory.doabooks.org/handle/20.500.12854/68836 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/2602 https://mdpi.com/books/pdfview/book/2602 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-513-6 10.3390/books978-3-03928-513-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039285129 9783039285136 154 Basel, Switzerland open access |
| spellingShingle | thema EDItEUR::M Medicine and Nursing Ricin Toxins |
| title | Ricin Toxins |
| title_full | Ricin Toxins |
| title_fullStr | Ricin Toxins |
| title_full_unstemmed | Ricin Toxins |
| title_short | Ricin Toxins |
| title_sort | ricin toxins |
| topic | thema EDItEUR::M Medicine and Nursing |
| topic_facet | thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20210501_9783039285129_582 |