Lassa Fever
Lassa virus causes Lassa fever disease in several countries in West Africa, where it is estimated to infect up to half million people causing roughly five thousand deaths each year. This deadly virus has also been introduced in multiple occasions into the western world, including the United States,...
Furkejuvvon:
| Materiálatiipa: | Online |
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| Giella: | eaŋgalasgiella |
| Almmustuhtton: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Fáttát: | |
| Liŋkkat: | ONIX_20210501_9783039366095_626 |
| Fáddágilkorat: |
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| _version_ | 1869525640173060096 |
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| collection | Directory of Open Access Books |
| description | Lassa virus causes Lassa fever disease in several countries in West Africa, where it is estimated to infect up to half million people causing roughly five thousand deaths each year. This deadly virus has also been introduced in multiple occasions into the western world, including the United States, United Kingdom, Netherlands, Sweden, and Germany. Lassa virus infection, which is often misdiagnosed, can lead to a wide range of disease symptoms ranging from mild flu-like symptoms to bleeding disorders, multi-organ failure, and death. Despite some major discoveries made in recent years of research on Lassa fever, there are still many unresolved key issues that hamper the development of effective vaccines and therapies. Some of these issues include a detailed understanding of the viral and participating host factors in completing the virus life cycle, in mediating disease pathogenesis or protection, and in activating or suppressing host immune responses against virus infection. This book is devoted to understanding some of these important issues. Expert and timely contributions in the form of editorial and original research and review articles on Lassa fever viral replication, disease pathogenesis and protection, host immune modulations, and other related hot topics are presented in this publication. |
| format | Online |
| id | doab-20.500.12854ir-68880 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-688802024-03-28T03:33:45Z Lassa Fever Ly, Hinh Lassa virus disease (LVD) vaccine breadth mimicry B cell anergy conserved antigens Fc-gamma receptors conformational antigens broadly-neutralizing antibodies focused immunity dominant and subdominant epitopes cross-restriction Lassa virus Z protein late domain PPXY budding release matrix protein phosphorylation arenavirus mass spectrometry viral glycoprotein viral entry viral fusion fusion protein Lassa virus vaccine ML29 vaccine STAT-1-/- mice Mopeia virus interfering particles Lassa fever LASV virus–host interactions entry replication Lassa vaccine replication-deficient MVA vector VLP formation single-dose efficacy cell-mediated immunity arenaviruses viral hemorrhagic fevers animal models mammarenavirus vaccine virulence pathogenesis innate immunity adaptive immunity COVID-19 thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Lassa virus causes Lassa fever disease in several countries in West Africa, where it is estimated to infect up to half million people causing roughly five thousand deaths each year. This deadly virus has also been introduced in multiple occasions into the western world, including the United States, United Kingdom, Netherlands, Sweden, and Germany. Lassa virus infection, which is often misdiagnosed, can lead to a wide range of disease symptoms ranging from mild flu-like symptoms to bleeding disorders, multi-organ failure, and death. Despite some major discoveries made in recent years of research on Lassa fever, there are still many unresolved key issues that hamper the development of effective vaccines and therapies. Some of these issues include a detailed understanding of the viral and participating host factors in completing the virus life cycle, in mediating disease pathogenesis or protection, and in activating or suppressing host immune responses against virus infection. This book is devoted to understanding some of these important issues. Expert and timely contributions in the form of editorial and original research and review articles on Lassa fever viral replication, disease pathogenesis and protection, host immune modulations, and other related hot topics are presented in this publication. 2021-05-01T15:31:57Z 2021-05-01T15:31:57Z 2020 book ONIX_20210501_9783039366095_626 9783039366095 9783039366101 https://directory.doabooks.org/handle/20.500.12854/68880 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/2647 https://mdpi.com/books/pdfview/book/2647 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03936-610-1 10.3390/books978-3-03936-610-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039366095 9783039366101 132 Basel, Switzerland open access |
| spellingShingle | Lassa virus disease (LVD) vaccine breadth mimicry B cell anergy conserved antigens Fc-gamma receptors conformational antigens broadly-neutralizing antibodies focused immunity dominant and subdominant epitopes cross-restriction Lassa virus Z protein late domain PPXY budding release matrix protein phosphorylation arenavirus mass spectrometry viral glycoprotein viral entry viral fusion fusion protein Lassa virus vaccine ML29 vaccine STAT-1-/- mice Mopeia virus interfering particles Lassa fever LASV virus–host interactions entry replication Lassa vaccine replication-deficient MVA vector VLP formation single-dose efficacy cell-mediated immunity arenaviruses viral hemorrhagic fevers animal models mammarenavirus vaccine virulence pathogenesis innate immunity adaptive immunity COVID-19 thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Lassa Fever |
| title | Lassa Fever |
| title_full | Lassa Fever |
| title_fullStr | Lassa Fever |
| title_full_unstemmed | Lassa Fever |
| title_short | Lassa Fever |
| title_sort | lassa fever |
| topic | Lassa virus disease (LVD) vaccine breadth mimicry B cell anergy conserved antigens Fc-gamma receptors conformational antigens broadly-neutralizing antibodies focused immunity dominant and subdominant epitopes cross-restriction Lassa virus Z protein late domain PPXY budding release matrix protein phosphorylation arenavirus mass spectrometry viral glycoprotein viral entry viral fusion fusion protein Lassa virus vaccine ML29 vaccine STAT-1-/- mice Mopeia virus interfering particles Lassa fever LASV virus–host interactions entry replication Lassa vaccine replication-deficient MVA vector VLP formation single-dose efficacy cell-mediated immunity arenaviruses viral hemorrhagic fevers animal models mammarenavirus vaccine virulence pathogenesis innate immunity adaptive immunity COVID-19 thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Lassa virus disease (LVD) vaccine breadth mimicry B cell anergy conserved antigens Fc-gamma receptors conformational antigens broadly-neutralizing antibodies focused immunity dominant and subdominant epitopes cross-restriction Lassa virus Z protein late domain PPXY budding release matrix protein phosphorylation arenavirus mass spectrometry viral glycoprotein viral entry viral fusion fusion protein Lassa virus vaccine ML29 vaccine STAT-1-/- mice Mopeia virus interfering particles Lassa fever LASV virus–host interactions entry replication Lassa vaccine replication-deficient MVA vector VLP formation single-dose efficacy cell-mediated immunity arenaviruses viral hemorrhagic fevers animal models mammarenavirus vaccine virulence pathogenesis innate immunity adaptive immunity COVID-19 thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20210501_9783039366095_626 |