Epithelial-Mesenchymal Plasticity in Cancer Metastasis
Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties,...
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| Формат: | Online |
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| Язык: | английский |
| Опубликовано: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Предметы: | |
| Online-ссылка: | ONIX_20210501_9783039367245_656 |
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| _version_ | 1869518660361519104 |
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| collection | Directory of Open Access Books |
| description | Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties, therapy resistance, and tumor microenvironment interactions. With the on-going debate about the requirement of EMT for cancer metastasis, an emerging focus on intermediate states of EMT and its reverse process mesenchymal-epithelial transition (MET) offer new ideas for metastatic requirements and the dynamics of EMT/MET during the entire metastatic cascade. Therefore, we would like to initiate discussions on viewing EMT and its downstream signaling networks as a fulcrum of cellular plasticity, and a facilitator of the adaptive responses of cancer cells to distant organ microenvironments and various therapeutic assaults. We hereby invite scientists who have prominently contributed to this field, and whose valuable insights have led to the appreciation of epithelial-mesenchymal plasticity as a more comprehensive mediator of the adaptive response of cancer cells, with huge implications in metastasis, drug resistance, tumor relapse, and patient survival. |
| format | Online |
| id | doab-20.500.12854ir-68910 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-689102024-03-30T23:22:21Z Epithelial-Mesenchymal Plasticity in Cancer Metastasis Jolly, Mohit Kumar Celia-Terrassa, Toni thema EDItEUR::M Medicine and Nursing Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties, therapy resistance, and tumor microenvironment interactions. With the on-going debate about the requirement of EMT for cancer metastasis, an emerging focus on intermediate states of EMT and its reverse process mesenchymal-epithelial transition (MET) offer new ideas for metastatic requirements and the dynamics of EMT/MET during the entire metastatic cascade. Therefore, we would like to initiate discussions on viewing EMT and its downstream signaling networks as a fulcrum of cellular plasticity, and a facilitator of the adaptive responses of cancer cells to distant organ microenvironments and various therapeutic assaults. We hereby invite scientists who have prominently contributed to this field, and whose valuable insights have led to the appreciation of epithelial-mesenchymal plasticity as a more comprehensive mediator of the adaptive response of cancer cells, with huge implications in metastasis, drug resistance, tumor relapse, and patient survival. 2021-05-01T15:32:35Z 2021-05-01T15:32:35Z 2020 book ONIX_20210501_9783039367245_656 9783039367245 9783039367252 https://directory.doabooks.org/handle/20.500.12854/68910 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/2677 https://mdpi.com/books/pdfview/book/2677 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03936-725-2 10.3390/books978-3-03936-725-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039367245 9783039367252 512 Basel, Switzerland open access |
| spellingShingle | thema EDItEUR::M Medicine and Nursing Epithelial-Mesenchymal Plasticity in Cancer Metastasis |
| title | Epithelial-Mesenchymal Plasticity in Cancer Metastasis |
| title_full | Epithelial-Mesenchymal Plasticity in Cancer Metastasis |
| title_fullStr | Epithelial-Mesenchymal Plasticity in Cancer Metastasis |
| title_full_unstemmed | Epithelial-Mesenchymal Plasticity in Cancer Metastasis |
| title_short | Epithelial-Mesenchymal Plasticity in Cancer Metastasis |
| title_sort | epithelial mesenchymal plasticity in cancer metastasis |
| topic | thema EDItEUR::M Medicine and Nursing |
| topic_facet | thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20210501_9783039367245_656 |