Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis
Worldwide, liver fibrosis is a major cause of morbidity and mortality and is associated with a high medical and economic burden. It is the common consequence of chronic liver injury due to various etiologies. During fibrogenesis, there is a progressive substitution of the liver parenchyma by scar ti...
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| Materialtyp: | Online |
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| Språk: | engelska |
| Utgiven: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Ämnen: | |
| Länkar: | ONIX_20210501_9783039361885_664 |
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| _version_ | 1869517467220443136 |
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| collection | Directory of Open Access Books |
| description | Worldwide, liver fibrosis is a major cause of morbidity and mortality and is associated with a high medical and economic burden. It is the common consequence of chronic liver injury due to various etiologies. During fibrogenesis, there is a progressive substitution of the liver parenchyma by scar tissue. Recent advances in the understanding of the history of liver fibrosis have shown that the pathogenesis is driven by different cell types and a large variety of soluble mediators. At present, scientists working in this field aim to increase basic knowledge, improve diagnostics, and try to translate experimental findings into new treatment modalities. This book includes 12 selected contributions from the Special Issue “Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis” that was published in Cells. These articles summarize current perspectives and findings in hepatic fibrosis research showing how scientists try to use basic scientific research to create new therapies and diagnostics. |
| format | Online |
| id | doab-20.500.12854ir-68918 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-689182024-04-01T23:19:18Z Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis Weiskirchen, Ralf thema EDItEUR::N History and Archaeology::NH History thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues Worldwide, liver fibrosis is a major cause of morbidity and mortality and is associated with a high medical and economic burden. It is the common consequence of chronic liver injury due to various etiologies. During fibrogenesis, there is a progressive substitution of the liver parenchyma by scar tissue. Recent advances in the understanding of the history of liver fibrosis have shown that the pathogenesis is driven by different cell types and a large variety of soluble mediators. At present, scientists working in this field aim to increase basic knowledge, improve diagnostics, and try to translate experimental findings into new treatment modalities. This book includes 12 selected contributions from the Special Issue “Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis” that was published in Cells. These articles summarize current perspectives and findings in hepatic fibrosis research showing how scientists try to use basic scientific research to create new therapies and diagnostics. 2021-05-01T15:32:45Z 2021-05-01T15:32:45Z 2020 book ONIX_20210501_9783039361885_664 9783039361885 9783039361892 https://directory.doabooks.org/handle/20.500.12854/68918 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/2685 https://mdpi.com/books/pdfview/book/2685 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03936-189-2 10.3390/books978-3-03936-189-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039361885 9783039361892 276 Basel, Switzerland open access |
| spellingShingle | thema EDItEUR::N History and Archaeology::NH History thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis |
| title | Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis |
| title_full | Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis |
| title_fullStr | Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis |
| title_full_unstemmed | Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis |
| title_short | Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis |
| title_sort | cellular and molecular mechanisms underlying the pathogenesis of hepatic fibrosis |
| topic | thema EDItEUR::N History and Archaeology::NH History thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues |
| topic_facet | thema EDItEUR::N History and Archaeology::NH History thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues |
| url | ONIX_20210501_9783039361885_664 |