Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment
ROS were long considered one of the key players in tissue injury. Indeed, overproduction of ROS results in oxidative stress, a process leading to the development of many pathological conditions. For the treatment of these conditions, the use of antioxidants was proposed. Over time, it was shown that...
I tiakina i:
| Hōputu: | Online |
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| Reo: | Ingarihi |
| I whakaputaina: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Ngā marau: | |
| Urunga tuihono: | ONIX_20210501_9783039362820_719 |
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Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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| _version_ | 1869528016180215808 |
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| collection | Directory of Open Access Books |
| description | ROS were long considered one of the key players in tissue injury. Indeed, overproduction of ROS results in oxidative stress, a process leading to the development of many pathological conditions. For the treatment of these conditions, the use of antioxidants was proposed. Over time, it was shown that ROS at low concentrations act as signaling molecules, leading to the regulation of physiological functions. Moreover, several interventions that increase ROS generation activate stress-adaptive responses that extend the lifespan. It was also shown that excessive use of antioxidants can counter the beneficial effects of ROS. Currently, much progress has been made in understanding the role of ROS in human diseases and aging, as well as in the regulation of physiological functions, and in identifying the signaling pathways involved in ROS. However, much remains to be understood about the mutual interactions among signaling pathways underlying organisms’ adaptive responses, their modifications (which occur during aging), and some disease states. The aim of this Special Issue is to underline the effects of ROS production and antioxidant treatment in living organisms, focusing on their impact on health, disease, and aging. |
| format | Online |
| id | doab-20.500.12854ir-68973 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-689732024-03-28T03:33:51Z Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment Di Meo, Sergio Venditti, Paola Napolitano, Gaetana CTCL apoptosis cell viability c-FLIP XIAP artemisinin SH-SY5Y cells hippocampal neurons H2O2 AMPK pathway atherosclerosis sphingomyelin synthase 2 endothelial dysfunction endoplasmic reticulum stress β-catenin insulin resistance cancer cardiovascular disease neurodegenerative disorders exercise mitochondria oxidative stress PGC-1 Nrf2 UCPs ROS light DNA damage evolution D-box cavefish Spalax trimethylamine N-oxide cardiomyocytes cardiotoxicity mitochondrial membrane potential CORM-2 NADPH oxidase AP-1 HO-1 Renal cell carcinoma (RCC) reactive oxygen species (ROS) glutathione (GSH) metabolism cancer therapy clear cell RCC papillary RCC chromophobe RCC sarcopenia reactive oxygen species redox signaling antioxidant supplementation protein aggregation redox proteinopathy peroxiredoxins tumorigenesis ROS scavengers n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ROS were long considered one of the key players in tissue injury. Indeed, overproduction of ROS results in oxidative stress, a process leading to the development of many pathological conditions. For the treatment of these conditions, the use of antioxidants was proposed. Over time, it was shown that ROS at low concentrations act as signaling molecules, leading to the regulation of physiological functions. Moreover, several interventions that increase ROS generation activate stress-adaptive responses that extend the lifespan. It was also shown that excessive use of antioxidants can counter the beneficial effects of ROS. Currently, much progress has been made in understanding the role of ROS in human diseases and aging, as well as in the regulation of physiological functions, and in identifying the signaling pathways involved in ROS. However, much remains to be understood about the mutual interactions among signaling pathways underlying organisms’ adaptive responses, their modifications (which occur during aging), and some disease states. The aim of this Special Issue is to underline the effects of ROS production and antioxidant treatment in living organisms, focusing on their impact on health, disease, and aging. 2021-05-01T15:34:30Z 2021-05-01T15:34:30Z 2020 book ONIX_20210501_9783039362820_719 9783039362820 9783039362837 https://directory.doabooks.org/handle/20.500.12854/68973 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/2741 https://mdpi.com/books/pdfview/book/2741 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03936-283-7 10.3390/books978-3-03936-283-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039362820 9783039362837 236 Basel, Switzerland open access |
| spellingShingle | CTCL apoptosis cell viability c-FLIP XIAP artemisinin SH-SY5Y cells hippocampal neurons H2O2 AMPK pathway atherosclerosis sphingomyelin synthase 2 endothelial dysfunction endoplasmic reticulum stress β-catenin insulin resistance cancer cardiovascular disease neurodegenerative disorders exercise mitochondria oxidative stress PGC-1 Nrf2 UCPs ROS light DNA damage evolution D-box cavefish Spalax trimethylamine N-oxide cardiomyocytes cardiotoxicity mitochondrial membrane potential CORM-2 NADPH oxidase AP-1 HO-1 Renal cell carcinoma (RCC) reactive oxygen species (ROS) glutathione (GSH) metabolism cancer therapy clear cell RCC papillary RCC chromophobe RCC sarcopenia reactive oxygen species redox signaling antioxidant supplementation protein aggregation redox proteinopathy peroxiredoxins tumorigenesis ROS scavengers n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment |
| title | Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment |
| title_full | Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment |
| title_fullStr | Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment |
| title_full_unstemmed | Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment |
| title_short | Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment |
| title_sort | physiological and pathological role of ros benefits and limitations of antioxidant treatment |
| topic | CTCL apoptosis cell viability c-FLIP XIAP artemisinin SH-SY5Y cells hippocampal neurons H2O2 AMPK pathway atherosclerosis sphingomyelin synthase 2 endothelial dysfunction endoplasmic reticulum stress β-catenin insulin resistance cancer cardiovascular disease neurodegenerative disorders exercise mitochondria oxidative stress PGC-1 Nrf2 UCPs ROS light DNA damage evolution D-box cavefish Spalax trimethylamine N-oxide cardiomyocytes cardiotoxicity mitochondrial membrane potential CORM-2 NADPH oxidase AP-1 HO-1 Renal cell carcinoma (RCC) reactive oxygen species (ROS) glutathione (GSH) metabolism cancer therapy clear cell RCC papillary RCC chromophobe RCC sarcopenia reactive oxygen species redox signaling antioxidant supplementation protein aggregation redox proteinopathy peroxiredoxins tumorigenesis ROS scavengers n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | CTCL apoptosis cell viability c-FLIP XIAP artemisinin SH-SY5Y cells hippocampal neurons H2O2 AMPK pathway atherosclerosis sphingomyelin synthase 2 endothelial dysfunction endoplasmic reticulum stress β-catenin insulin resistance cancer cardiovascular disease neurodegenerative disorders exercise mitochondria oxidative stress PGC-1 Nrf2 UCPs ROS light DNA damage evolution D-box cavefish Spalax trimethylamine N-oxide cardiomyocytes cardiotoxicity mitochondrial membrane potential CORM-2 NADPH oxidase AP-1 HO-1 Renal cell carcinoma (RCC) reactive oxygen species (ROS) glutathione (GSH) metabolism cancer therapy clear cell RCC papillary RCC chromophobe RCC sarcopenia reactive oxygen species redox signaling antioxidant supplementation protein aggregation redox proteinopathy peroxiredoxins tumorigenesis ROS scavengers n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20210501_9783039362820_719 |