Role of Genomics in the Management of Hypertension

Arterial hypertension affects about 1 billion people worldwide and it is the strongest modifiable risk factor for cardiovascular disease and related disability. Since the initial discovery of rare monogenic disorders with large effects, the role of genomics has evolved into large genome-wide associa...

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מידע ביבליוגרפי
פורמט:	Online
שפה:	אנגלית
יצא לאור:	MDPI - Multidisciplinary Digital Publishing Institute 2021
נושאים:	atrial natriuretic peptide T2238C variant endothelial dysfunction smooth muscle cells contraction platelet aggregation epigenetics cardiovascular diseases renin low-renin hypertension mineralocorticoid receptor genetics aldosterone essential hypertension blood pressure genome-wide association studies exome microarray next-generation sequencing rare variants rare-variants association testing burden test sequence kernel association test hypokalemia low renin hypertension monogenic hypertension Liddle syndrome SCNN1A SCNN1B SCNN1G non-coding RNA micro RNA primary aldosteronism aldosterone-producing adenoma transcriptome profiing DNA methylation histone modifications vascular smooth muscle cells endothelial cells Kruppel-like factor 15 left ventricular hypertrophy cardiac hypertrophy heart failure genetics of left ventricular hypertrophy fibromuscular dysplasia non atherosclerotic vascular stenosis PHACTR1 genetic association cervical artery dissection spontaneous coronary arteries dissection CRY1 CRY2 HSD3B1 HSD3B2 cardio-tonic steroids endogenous ouabain adducin renal damage African American ARMC5 GRK4 CACNA1D endocrine hypertension thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
גישה מקוונת:	ONIX_20210501_9783039366279_720
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

תיאור
סיכום:	Arterial hypertension affects about 1 billion people worldwide and it is the strongest modifiable risk factor for cardiovascular disease and related disability. Since the initial discovery of rare monogenic disorders with large effects, the role of genomics has evolved into large genome-wide association studies detecting common variants with a modest effect size. Similarly, pharmacogenomics has emerged as a new tool for understanding variability in drug response, to maximize efficacy and reduce toxicity. This book presents the most recent advances in the field of genetics and genomics of arterial hypertension and their potential impact on clinical management. The book is a useful tool for clinicians but also to the research community and those who want to be updated in the field.

Role of Genomics in the Management of Hypertension

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