Peptide Nucleic Acids
This book compiles four review articles and four research papers that highlight recent developments in the field of peptide nucleic acid (PNA) chemistry and biomedicine. The review articles encompass a variety of fields related to PNA, emphasizing the versatility of this DNA mimic. Two excellent rev...
שמור ב:
| פורמט: | Online |
|---|---|
| שפה: | אנגלית |
| יצא לאור: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
|
| נושאים: | |
| גישה מקוונת: | ONIX_20210501_9783039368860_803 |
| תגים: |
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!
|
| _version_ | 1869527045811208192 |
|---|---|
| collection | Directory of Open Access Books |
| description | This book compiles four review articles and four research papers that highlight recent developments in the field of peptide nucleic acid (PNA) chemistry and biomedicine. The review articles encompass a variety of fields related to PNA, emphasizing the versatility of this DNA mimic. Two excellent reviews detail the use of PNA for molecular diagnostics of miRNAs and genetic point mutations (SNPs). Another review provides a comprehensive analysis of the various approaches for gene editing using chemically modified PNA molecules. Lastly, PNA molecules are elegantly described as effective (antisense) antimicrobial agents in the final review. The high binding affinity of PNA to complementary DNA and RNA is highlighted in three research articles. Two articles show how PNA molecules act as splice modulating and RNA masking molecules, separately. In another contribution, the high affinity and achiral characteristics of PNAs are used to developed a stable L-DNA-based catalytic hairpin assembly. Lastly, chemically-modified PNA molecules are shown to be superior probes for SNP detection. Altogether, these studies illustrate how PNA molecules may be useful for a variety of biomedical applications as either therapeutic or diagnostic agents. |
| format | Online |
| id | doab-20.500.12854ir-69057 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-690572024-03-31T13:09:50Z Peptide Nucleic Acids Yavin, Eylon RNA structure strand invasion antisense PNA exon skipping exon inclusion oligonucleotides peptide nucleic acid (PNA) antibacterials RNA PNA transporters conjugates bacterial resistance peptide nucleic acids triplex gene editing structure recombination repair nanoparticles β-thalassemia cystic fibrosis peptide nucleic acid tolane single nucleotide polymorphism influenza virus drug resistance peptide nucleic acids (PNAs) single-nucleotide polymorphism (SNP) polymerase chain reaction (PCR) cancer. catalytic hairpin assembly (CHA) strand-displacement reaction l-DNA microRNA fluorescence templated reactions light-triggered electrochemical biosensors colorimetric detection Peptide nucleic acids PNA-masking microRNAs miR-145-5p miRNA targeting delivery CFTR n/a thema EDItEUR::M Medicine and Nursing This book compiles four review articles and four research papers that highlight recent developments in the field of peptide nucleic acid (PNA) chemistry and biomedicine. The review articles encompass a variety of fields related to PNA, emphasizing the versatility of this DNA mimic. Two excellent reviews detail the use of PNA for molecular diagnostics of miRNAs and genetic point mutations (SNPs). Another review provides a comprehensive analysis of the various approaches for gene editing using chemically modified PNA molecules. Lastly, PNA molecules are elegantly described as effective (antisense) antimicrobial agents in the final review. The high binding affinity of PNA to complementary DNA and RNA is highlighted in three research articles. Two articles show how PNA molecules act as splice modulating and RNA masking molecules, separately. In another contribution, the high affinity and achiral characteristics of PNAs are used to developed a stable L-DNA-based catalytic hairpin assembly. Lastly, chemically-modified PNA molecules are shown to be superior probes for SNP detection. Altogether, these studies illustrate how PNA molecules may be useful for a variety of biomedical applications as either therapeutic or diagnostic agents. 2021-05-01T15:40:08Z 2021-05-01T15:40:08Z 2020 book ONIX_20210501_9783039368860_803 9783039368860 9783039368877 https://directory.doabooks.org/handle/20.500.12854/69057 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/2826 https://mdpi.com/books/pdfview/book/2826 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03936-887-7 10.3390/books978-3-03936-887-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039368860 9783039368877 154 Basel, Switzerland open access |
| spellingShingle | RNA structure strand invasion antisense PNA exon skipping exon inclusion oligonucleotides peptide nucleic acid (PNA) antibacterials RNA PNA transporters conjugates bacterial resistance peptide nucleic acids triplex gene editing structure recombination repair nanoparticles β-thalassemia cystic fibrosis peptide nucleic acid tolane single nucleotide polymorphism influenza virus drug resistance peptide nucleic acids (PNAs) single-nucleotide polymorphism (SNP) polymerase chain reaction (PCR) cancer. catalytic hairpin assembly (CHA) strand-displacement reaction l-DNA microRNA fluorescence templated reactions light-triggered electrochemical biosensors colorimetric detection Peptide nucleic acids PNA-masking microRNAs miR-145-5p miRNA targeting delivery CFTR n/a thema EDItEUR::M Medicine and Nursing Peptide Nucleic Acids |
| title | Peptide Nucleic Acids |
| title_full | Peptide Nucleic Acids |
| title_fullStr | Peptide Nucleic Acids |
| title_full_unstemmed | Peptide Nucleic Acids |
| title_short | Peptide Nucleic Acids |
| title_sort | peptide nucleic acids |
| topic | RNA structure strand invasion antisense PNA exon skipping exon inclusion oligonucleotides peptide nucleic acid (PNA) antibacterials RNA PNA transporters conjugates bacterial resistance peptide nucleic acids triplex gene editing structure recombination repair nanoparticles β-thalassemia cystic fibrosis peptide nucleic acid tolane single nucleotide polymorphism influenza virus drug resistance peptide nucleic acids (PNAs) single-nucleotide polymorphism (SNP) polymerase chain reaction (PCR) cancer. catalytic hairpin assembly (CHA) strand-displacement reaction l-DNA microRNA fluorescence templated reactions light-triggered electrochemical biosensors colorimetric detection Peptide nucleic acids PNA-masking microRNAs miR-145-5p miRNA targeting delivery CFTR n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | RNA structure strand invasion antisense PNA exon skipping exon inclusion oligonucleotides peptide nucleic acid (PNA) antibacterials RNA PNA transporters conjugates bacterial resistance peptide nucleic acids triplex gene editing structure recombination repair nanoparticles β-thalassemia cystic fibrosis peptide nucleic acid tolane single nucleotide polymorphism influenza virus drug resistance peptide nucleic acids (PNAs) single-nucleotide polymorphism (SNP) polymerase chain reaction (PCR) cancer. catalytic hairpin assembly (CHA) strand-displacement reaction l-DNA microRNA fluorescence templated reactions light-triggered electrochemical biosensors colorimetric detection Peptide nucleic acids PNA-masking microRNAs miR-145-5p miRNA targeting delivery CFTR n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20210501_9783039368860_803 |